Article
Immunology
Lilli Leimi, Jessica R. Koski, Outi Kilpivaara, Kim Vettenranta, A. Inkeri Lokki, Seppo Meri
Summary: This study investigated genetic complement system variants in patients with documented endotheliopathy and found that variants in complement genes may be related to endotheliopathy and poor prognosis in these patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Eleni Gavriilaki, Vincent T. Ho, Wilhelm Schwaeble, Thomas Dudler, Mohamed Daha, Teizo Fujita, Sonata Jodele
Summary: HSCT-TMA is a life-threatening syndrome that may be caused by endothelial injury and complement activation triggered by hematopoietic stem cell transplantation and associated risk factors. Activation of the complement system and the coagulation cascade may lead to a procoagulant state, ultimately resulting in organ damage and failure. Complement inhibitors targeting various complement pathways are being tested in clinical trials for the treatment of HSCT-TMA.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Clinical Neurology
Zhuo Wang, Munan Zhao, Sujun Gao
Summary: The incidence of epileptic seizures after allogeneic hematopoietic stem cell transplantation has raised concerns among clinicians for its impact on patient survival and quality of life. This review aims to elucidate the incidence, etiologies, mechanisms, clinical manifestations, therapeutic schedule, and prognosis of post-transplantation seizures to improve doctors' understanding and management of this complication for better patient outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Aryan Shiari, Mo'ath Nassar, Ayman O. Soubani
Summary: Hematopoietic stem cell transplantation (HSCT) is used for treating both malignant and nonmalignant disorders, but patients remain at risk for post-transplant complications. Pulmonary complications, including infectious and non-infectious, highlight the importance of early identification and treatment of infections, as well as the toxicities related to chemoradiation and immunosuppressive drugs. This report serves as a guide for pulmonologists caring for these patients.
RESPIRATORY MEDICINE
(2021)
Article
Oncology
Hyewon Shin, Mi-Sun Yum, Min-Jee Kim, Jin Kyung Suh, Ho Joon Im, Hyery Kim, Kyung-Nam Koh, Tae-Sung Ko
Summary: Most children with neurologic complications and neuroimaging abnormalities during HSCT had recovered. However, children with neurologic complications associated with infectious causes, malignant disease or severe brain MRI abnormalities should be more carefully monitored during HSCT.
Article
Multidisciplinary Sciences
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella T. Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella, Hamideh Parhiz
Summary: This study developed a nanoparticle system that can target hematopoietic stem cells in vivo and achieved correction of diseased cells through mRNA delivery. Furthermore, this system enables non-genotoxic conditioning for stem cells, providing a new approach for HSCT.
Article
Pharmacology & Pharmacy
D. Iskender, M. Ibanoglu, S. Secilmis, N. A. Baysal, M. K. Cakar, M. S. Dal, B. U. Ulu, S. Y. Ergani, A. Kaymak, T. T. Ilhan, S. Basci, T. N. Yigenoglu, C. Iskender, F. Altuntas
Summary: This study retrospectively investigated the pregnancy outcomes of patients who underwent stem cell transplantation (SCT) and determined the reasons for avoiding pregnancy. The results showed that patients who became pregnant after SCT had a higher rate of pregnancy complications, but achieved similar live birth rates as the healthy population. Many patients have concerns about pregnancy and should be counseled appropriately.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Oncology
Seom Gim Kong, Seri Jeong, Sangjin Lee, Jee-Yeong Jeong, Da Jung Kim, Ho Sup Lee
Summary: The study revealed that the cumulative incidence rates of early TRM at 50 and 100 days were 2.9% and 8.3% respectively. Predictable factors for early TRM included age, time from diagnosis to transplantation, number of prior transplantations, graft source, and previous iron chelation therapy.
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Immunology
Balaji Balakrishnan, Uday Prakash Kulkarni, Aswin Anand Pai, Raveen Stephen Stallon Illangeswaran, Ezhilpavai Mohanan, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian
Summary: Hematopoietic cell transplantation (HCT) is an effective treatment for hematological diseases, but early complications such as GVHD and SOS limit its success. Research has focused on discovering blood-based biomarkers to diagnose and predict complications and therapy response. However, these biomarkers are not yet used in routine clinical practice. This review summarizes the biomarkers for early complications post-HCT, ongoing trials, and challenges in using them.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tirthankar Sen, Rajkumar P. Thummer
Summary: The human microbiota plays a significant role in organ transplantation outcomes and rejection risk, with complex interactions existing between different microbiotas and the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Soheila Montazersaheb, Ali Ehsani, Ezzatollah Fathi, Raheleh Farahzadi, Ilja Vietor
Summary: Autophagy is a fundamental process that helps cells adapt to metabolic stress by degrading and recycling intracellular components. It plays a crucial role in various aspects of allogeneic hematopoietic stem cell transplantation (HSCT), including the survival and function of hematopoietic stem cells, T-cell differentiation, antigen presentation, and responsiveness to cytokine stimulation. However, the overall role of autophagy in HSCT remains unclear, highlighting the need for further understanding to improve transplant outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Ashley M. Nelson, Alexandra A. Erdmann, Christopher L. Coe, Mark B. Juckett, Keayra Morris, Jennifer M. Knight, Peiman Hematti, Erin S. Costanzo
Summary: Increased synthesis and release of inflammatory signalling proteins are common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT). This study examined the relationship between markers of inflammatory activity and depression symptoms following HCT. The results showed that patients with elevated levels of IL-6 and IL-10 reported more severe depression symptoms post-HCT, especially in terms of neurovegetative symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Rebecca Isabel Wurm-Kuczera, Judith Buentzel, Julia Felicitas Leni Koenig, Tobias Legler, Jan-Jakob Valk, Justin Hasenkamp, Wolfram Jung, Jan-Gerd Rademacher, Peter Korsten, Gerald Georg Wulf
Summary: Sarcoidosis is a disease characterized by altered immune response and inflammatory granulomatous tissue infiltration. It may occur during immune reconstitution after HSCT, with glucocorticoid treatment resolving symptoms effectively. The HLA allele association reflects that observed in the general population.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xiaofeng Zhou, Bethany B. Moore
Summary: Pulmonary infections are a major concern for hematopoietic cell transplantation recipients, with mouse models playing a key role in understanding the impacts of these infections. Studies have shown that post-transplant infectious complications adversely affect innate immunity, and previous infections may contribute to noninfectious pulmonary issues post-HCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Pedro Castro, Marta Palomo, Ana Belen Moreno-Castano, Sara Fernandez, Sergi Torramade-Moix, Georgina Pascual, Julia Martinez-Sanchez, Edward Richardson, Adrian Tellez, Josep M. Nicolas, Enric Carreras, Paul G. Richardson, Juan Jose Badimon, Gines Escolar, Maribel Diaz-Ricart
Summary: Patients with COVID-19 can exhibit a wide range of disease severities, with a majority being asymptomatic while some progress to critical illness. The disease timeline typically includes incubation, mild symptoms, severe hyperinflammatory response, and post-acute sequelae. Endothelial dysfunction appears to be a crucial factor in the pathobiology of severe COVID-19 complications, highlighting the potential for targeting the endothelium in prevention and treatment strategies.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Critical Care Medicine
Sara Fernandez, Ana B. Moreno-Castano, Marta Palomo, Julia Martinez-Sanchez, Sergi Torramade-Moix, Adrian Tellez, Helena Ventosa, Ferran Segui, Gines Escolar, Enric Carreras, Josep M. Nicolas, Edward Richardson, David Garcia-Bernal, Carmelo Carlo-Stella, Jose M. Moraleda, Paul G. Richardson, Maribel Diaz-Ricart, Pedro Castro
Summary: COVID-19 patients exhibit increased circulating biomarkers of endothelial damage, complement activation, and fibrinolytic dysregulation, associated with disease severity. COVID-19 endotheliopathy differs from sepsis syndrome, in which endothelial damage is also a critical feature of pathobiology.
Article
Biophysics
R. Parody, I Sanchez-Ortega, A. Mussetti, B. Patino, M. Arnan, H. Pomares, E. Gonzalez-Barca, S. Mercadal, C. Boque, C. Maluquer, I Carro, M. Pena, V Clapes, S. Verdesoto, G. Bustamante, Ac Oliveira, C. Baca, E. Cabezudo, C. Talarn, L. Escoda, S. Ortega, N. Garcia, M. Isabel Gonzalez-Medina, Mar Sanchez-Salmeron, C. Fuste, J. Villa, E. Carreras, E. Domingo-Domenech, A. Sureda
Summary: Traceability of patients who are candidates for Hematopoietic cell transplant (HCT) is crucial in ensuring program quality. Analysis of epidemiological data from a 4-year registry showed a high cancellation rate of UD research, emphasizing the need for further optimization of donor algorithms.
BONE MARROW TRANSPLANTATION
(2022)
Article
Biophysics
Ana Belen Moreno-Castano, Marta Palomo, Sergi Torramade-Moix, Julia Martinez-Sanchez, Alex Ramos, Patricia Molina, Marc Pino, Pilar Gomez-Ramirez, Laura Bonastre, Maria Teresa Solano, Gines Escolar, Montserrat Rovira, Luis Gerardo Rodriguez-Lobato, Gonzalo Gutierrez-Garcia, Enric Carreras, Francesc Fernandez-Aviles, Maribel Diaz-Ricart
Summary: Engraftment syndrome (ES) is a common complication after autologous hematopoietic cell transplantation (auto-HCT) and may be associated with endothelial damage. The study found that ES patients had higher levels of circulating endothelial cell damage markers, indicating endothelial activation prior to ES development.
BONE MARROW TRANSPLANTATION
(2022)
Review
Hematology
Gines Escolar, Maribel Diaz-Ricart, Jeffrey McCullough
Summary: Standard platelet concentrates stored at 22 degrees C have a limited shelf life of 5 days due to potential bacterial contamination. To prevent infections and ensure safety, pathogen reduction technologies (PRTs) have been adapted to treat platelet products, extending their shelf life and providing an additional safety layer. The impact of different PRTs on platelet quality, function, and clinical effectiveness is under constant examination, with the potential to prevent new emerging blood-borne diseases from reaching cellular blood components.
Article
Obstetrics & Gynecology
Marta Palomo, Lina Youssef, Alex Ramos, Sergi Torramade-Moix, Ana Belen Moreno-Castano, Julia Martinez-Sanchez, Laura Bonastre, Marc Pino, Pilar Gomez-Ramirez, Lidia Martin, Estefania Garcia Mateos, Pablo Sanchez, Sara Fernandez, Francesca Crovetto, Gines Escolar, Enric Carreras, Pedro Castro, Eduard Gratacos, Fatima Crispi, Maribel Diaz-Ricart
Summary: This study focused on differentiating between COVID-19 and preeclampsia in pregnant women by examining biomarkers and in vitro alterations in endothelial cells, providing important clues for the differential diagnosis of these conditions.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Miquel Blasco, Elena Guillen-Olmos, Maribel Diaz-Ricart, Marta Palomo
Summary: Thrombotic microangiopathies (TMA) are a group of disorders characterized by endothelial damage, with increasing evidence implicating the role of the complement system (CS) in their pathogenesis. However, the efficacy of complement-targeted therapies in these diseases remains uncertain.
FRONTIERS IN MEDICINE
(2022)
Meeting Abstract
Hematology
Ana Belen Moreno-Castano, Sara Fernandez, Marta Palomo, Julia Martinez-Sanchez, Alex Ramos, Patricia Molina, Marc Pino, Valentin Ortiz-Maldonado, Julio Delgado, Carlos Fernandez De Larrea, Alvaro Urbano-Ispizua, Gines Escolar, Enric Carreras, Francesc Fernandez-Aviles, Pedro Castro, Maribel Diaz-Ricart
Article
Biophysics
Julia Martinez-Sanchez, Roger Pascual-Diaz, Marta Palomo, Ana Belen Moreno-Castano, Helena Ventosa, Maria Queralt Salas, Montserrat Rovira, Gines Escolar, Enric Carreras, Maribel Diaz-Ricart
Summary: Post-transplantation cyclophosphamide (PTCy) reduces the occurrence of graft-versus-host disease (GVHD). Endothelial damage in allogeneic hematopoietic cell transplantation (allo-HCT) is caused by various factors and plays a role in HCT-related complications like GVHD. The impact of PTCy on the endothelium is not well understood. In this study, the researchers compared the effects of the cyclophosphamide analog MAF and cyclosporine A (CSA) on endothelial cells (ECs), and found that both compounds caused endothelial damage, but with different characteristics and intensities.
BONE MARROW TRANSPLANTATION
(2023)
Editorial Material
Biophysics
Selim Corbacioglu, Stephan A. Grupp, Paul Gerard Richardson, Rafael Duarte, Antonio Pagliuca, Tapani Ruutu, Kris Mahadeo, Enric Carreras
BONE MARROW TRANSPLANTATION
(2023)
Article
Cell Biology
Julia Martinez-Sanchez, Marta Palomo, Alexandra Pedraza, Ana Belen Moreno-Castano, Sergi Torramade-Moix, Montserrat Rovira, Maria Queralt Salas, Joan Cid, Gines Escolar, Olaf Penack, Enric Carreras, Maribel Diaz-Ricart
Summary: This study compared the endothelial proteomic profiles in response to serum from steroid-refractory acute GVHD (SR-aGVHD) and steroid-sensitive acute GVHD (SS-aGVHD) patients. The differentially expressed proteins were mainly associated with oxidative phosphorylation, inflammation and angiogenesis, cell survival, and oxidative stress. These findings provide insights into the mechanisms of response to steroids and may serve as potential biomarkers for steroid-treatment response in SR-aGVHD patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Ana Belen Moreno-Castano, Sara Fernandez, Helena Ventosa, Marta Palomo, Julia Martinez-Sanchez, Alex Ramos, Valentin Ortiz-Maldonado, Julio Delgado, Carlos Fernandez de Larrea, Alvaro Urbano-Ispizua, Olaf Penack, J. M. Nicolas, Adrian Tellez, Gines Escolar, Enric Carreras, Francesc Fernandez-Aviles, Pedro Castro, Maribel Diaz-Ricart
Summary: CAR-T cell-based immunotherapy for hematological malignancies may lead to cytokine release and immune effector cell-associated neurotoxicity syndromes. This study found that markers of endothelial dysfunction, innate immunity activation, and hemostatic imbalance could potentially be used as laboratory tools for predicting and differentiating toxicities, as well as determining their severity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)