Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ana Claudia Scaraficci, Patricia Maria Fernandes, Fabio Abreu Alves, Jayr Schmidt Filho, Graziella Chagas Jaguar
Summary: The study revealed that the mean time for oral GVHD to develop after AHCT was 229 days, with pain and xerostomia being the main symptoms, and ulcers being the most common oral manifestation. Patients who received myeloablative conditioning regimen had a higher survival rate.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Hanne Beeckmans, Gene P. L. Ambrocio, Saskia Bos, Astrid Vermaut, Vincent Geudens, Arno Vanstapel, Bart M. Vanaudenaerde, Frans De Baets, Thomas L. A. Malfait, Marie-Paule Emonds, Dirk E. Van Raemdonck, Helene M. Schoemans, Robin Vos, Leuven Lung Transplant Grp
Summary: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by surfactant accumulation, and lung transplantation followed by hematopoietic stem cell transplantation may be an effective treatment for end-stage hereditary PAP-induced pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Eun Sil Kim, Yiyoung Kwon, Yon Ho Choe, Mi Jin Kim, Keon Hee Yoo
Summary: This study investigated the outcomes of gastrointestinal graft-versus-host disease (GVHD) in pediatric patients undergoing hematopoietic stem cell transplantation (HCT) according to the clinical, endoscopic, and histologic severity. The results showed that patients with higher histologic severity had earlier onset of GVHD symptoms and a higher proportion of severe clinical gastrointestinal GVHD. It highlights the importance of histologic evaluation in the diagnosis of clinical gastrointestinal GVHD.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Jin Lee, Yerang Shin, Youjin Kim, Hyeon-Su Im, Hyeyeong Kim, Su Jin Koh, Young Joo Min, Jae-Cheol Jo, Yunsuk Choi
Summary: This study investigated the serum protein profiles of patients who had undergone hematopoietic cell transplantation (HCT) to identify predictive biomarkers of severe acute graft versus host disease (GVHD). The results showed that higher levels of sVCAM-1 at baseline and on day + 14 could be significant predictive biomarkers of severe aGVHD.
Review
Gastroenterology & Hepatology
Fei Gao, Hengwei Wu, Limengmeng Wang, Yanmin Zhao, He Huang
Summary: Despite advancements in HSCT, GVHD, especially intestinal GVHD, still poses a significant challenge to the procedure. Traditionally, GVHD has been seen as an immune response, with the intestine as a target. However, factors such as altered intestinal microbiome and epithelial damage contribute to intestinal damage after transplantation. This review summarizes these factors and explores the potential of remodeling intestinal homeostasis in GVHD management.
Review
Cell Biology
Konradin F. Muskens, Caroline A. Lindemans, Mirjam E. Belderbos
Summary: GvHD is a major complication of HCT, causing severe hematopoietic dysfunction. Immune activation during GvHD damages hematopoietic stem cells and their niche in the bone marrow, leading to reduced functionality. Complications and treatments associated with HCT exacerbate hematopoietic dysfunction.
Article
Hematology
Sameem Abedin, Nahid Rashid, Mark Schroeder, Rizwan Romee, Mary Nauffal, Muhamad Alhaj Moustafa, Mohamed A. Kharfan-Dabaja, Jeanne Palmer, William Hogan, Mehrdad Hefazi, Samantha Larson, Shernan Holtan, Zachariah DeFilipp, Reena Jayani, Bhagirathbhai Dholaria, Joseph Pidala, Farhad Khimani, Michael R. Grunwald, Candace Butler, Mehdi Hamadani
Summary: Among 307 patients with SR-aGVHD, approximately 1/5 of patients showed resistance or intolerance to Ruxolitinib. The overall response rate to additional therapy was 36% in resistant patients with a median survival of 21 days; while 50% of intolerant patients continued to improve with additional therapy, with a median survival of 50 days. These data provide a baseline for future studies on SR-aGVHD.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jaspar Kloehn, Anne Kruchen, Kerstin Schuetze, Katharina Wustrau, Johanna Schrum, Ingo Mueller
Summary: Two pediatric patients underwent stem cell re-transplantation successfully, providing a new therapeutic option for steroid-refractory chronic graft-versus-host disease (SR-cGvHD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lydia Verlaat, Katarina Riesner, Martina Kalupa, Beate Jung, Sarah Mertlitz, Constanze Schwarz, Joerg Mengwasser, Claudine Fricke, Olaf Penack
Summary: Despite progress in allo-HCT, cGvHD remains a major hurdle, and improved pre-clinical models are needed. We developed two murine cGvHD models that resemble the clinical manifestations of cGvHD in patients. These models exhibited diverse signs of cGvHD in target organs and decelerated immune cell reconstitution. They can provide a deeper understanding of cGvHD pathology and facilitate the translation of experimental findings into human allo-HCT.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Weihao Wang, Tao Hong, Xiaoqi Wang, Rui Wang, Yuxuan Du, Qiangguo Gao, Shijie Yang, Xi Zhang
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for hematologic malignancies, but graft-versus-host disease (GVHD) remains a major obstacle. Reduction in regulatory T cells (Tregs) is associated with inflammatory dysregulation and immune tolerance maintenance, and immunoregulation may be helpful in preventing GVHD.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Oncology
Yiyin Chen, Yang Xu, Depei Wu
Summary: This review summarizes the significant advancements in prophylaxis against graft-versus-host disease (GvHD) discussed at the 2022 ASH Annual Meeting, including the use of innovative agents and regimens. Key advancements highlighted include abatacept, the first FDA-approved drug for acute GvHD prophylaxis, RGI-2001 that promotes regulatory T cell expansion, and cell therapies such as Orca-T and Orca-Q. These advancements offer promising strategies and options for GvHD prevention and may lead to improved post-transplant patient outcomes in terms of survival rates.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Surgery
Cecile Chague, Thomas Gautier, Ludivine Dal Zuffo, Jean-Paul Pais de Barros, Audrey Wetzel, Georges Tarris, Gaetan Pallot, Laurent Martin, Severine Valmary-Degano, Valerie Deckert, Laurent Lagrost, Etienne Daguindau, Philippe Saas
Summary: This study found that HDL deficiency leads to LPS accumulation and exacerbates aGVHD. However, administration of HDL isolated from human plasma significantly decreases the mortality and severity of aGVHD. HDL infusion also plays an important role in mitigating liver aGVHD by reducing immune infiltration and inflammation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Ning Wu, Ruoyang Liu, Shuang Liang, Haitao Gao, Lan-Ping Xu, Xiao-Hui Zhang, Jiangying Liu, Xiao-Jun Huang
Summary: In the development of aGVHD, gamma delta T cells were found to indirectly regulate the migration of CD4 T cells to target tissues, rather than directly triggering alloreactive responses. This study suggests a potential role for gamma delta T cells in recruiting alloreactive CD4 T cells through the expression of CXCR4, providing new insights into the mechanism of aGVHD and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)