Article
Biochemistry & Molecular Biology
Zoey X. Zheng, Etta Y. Liu, Q. Y. Wu, J. H. Wu, Tina T. X. Dong, Karl W. K. Tsim
Summary: Some flavonoids have been found to enhance the production of EPO (erythropoietin) by increasing the activity of hypoxia response element (HRE). This suggests that flavonoids may have potential as important components of food supplements for brain health.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Fisheries
Zhihai Huang, Weiliang Guan, Xiaobo Wei, Renchi Chen, Xiamin Lyu, Gaohai Zheng, Linchun Mao
Summary: The study found that HIF-1 alpha can protect whiteleg shrimp hemocytes from apoptosis caused by air exposure through upregulating the expression of HSP70 and decreasing intracellular ROS production.
Article
Critical Care Medicine
Hang Ruan, Yao-zhuo Li, Qin Zhang, Bin-ran Wang, Rongxue Wu, Shu-sheng Li, Xiao Ran
Summary: This study investigated the correlation between HIF-1a expression level and sepsis using bioinformatics analysis and clinical investigation. The results showed that HIF-1a expression level was higher in septic patients and correlated with disease severity and length of ICU stay.
Article
Medical Laboratory Technology
Qing-Wei Lv, Zi-Qiang Zheng, Han Zhang, Mi Guo, Liang-Jun Shen
Summary: The study showed a strong association between serum HIF-1 alpha concentrations and trauma severity as well as poor 90-day outcomes in severe traumatic brain injury (sTBI) patients. Serum HIF-1 alpha concentrations above 280.2 pg/ml were identified as a promising prognostic biomarker for poor outcomes with high sensitivity and specificity.
CLINICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Wenzhuo Cao, Yuanchao Wang, Lei Zheng, Zhaopeng Zhang, Shude Liu, Xiuqiang Dong, Weiwei Xian
Summary: This study investigated the exploitation pattern and stock status of the invertebrate resource (Oratosquilla oratoria) in the coastal waters of the Shandong Peninsula. The results showed that extreme fishing pressure without recovery was observed in both the north and south stocks, according to one assessment model. However, the other two assessment models indicated a gradual recovery in the northern stock and suggested that spatial exploitation pattern and seasonal differences should be considered in fishery management.
MARINE POLLUTION BULLETIN
(2023)
Article
Engineering, Marine
Guihao Li, Qinqin Song, Pengfei Zheng, Xiaoli Zhang, Songbao Zou, Yanfang Li, Xuelu Gao, Zhao Zhao, Jun Gong
Summary: The study found that both the abundance and genotypes of Marine Synechococcus are influenced by various environmental factors during seasonal hypoxia in coastal areas, with dissolved oxygen, pH, salinity, and temperature being the most important factors. Changes in population composition in diverse genotypes of Synechococcus occurred during the coastal hypoxia event, leading to thriving of the Synechococcus assemblages when hypoxia faded out.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Cell Biology
Bo Zhang, Yan Chen, Lei Bao, Weibo Luo
Summary: This study demonstrates that hypoxia upregulates the expression of GPT2 in GBM cells through HIF-2 activation. GPT2 is localized in the nucleus and mitochondria and can decrease α-ketoglutarate levels in GBM cells. Inhibition of GPT2 can reduce GBM cell growth and migration, and knockout of GPT2 inhibits GBM tumor growth in mice.
Article
Otorhinolaryngology
Gorkem Eskiizmir, Gizem Calibasi Kocal, Tugba Uysal, Hulya Ellidokuz, Yasemin Baspinar
Summary: This study investigated the diagnostic, predictive, and prognostic roles of hypoxia-related biomolecules in laryngeal neoplasms. The study found that hypoxia-inducible factor-2 is a prognostic factor in larynx cancer irrespective of treatment modality.
CLINICAL OTOLARYNGOLOGY
(2021)
Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Corine M. van der Weele, William R. Jeffery
Summary: Dark caves lacking primary productivity expose subterranean animals to hypoxia. Cavefish cope with hypoxia by increasing erythrocyte development and constitutive hif1 gene overexpression.
Article
Urology & Nephrology
Szu-Yu Pan, Pei-Zhen Tsai, Yu-Hsiang Chou, Yu-Ting Chang, Fan-Chi Chang, Yen-Ling Chiu, Wen-Chih Chiang, Tien Hsu, Yung-Ming Chen, Tzong-Shinn Chu, Shuei-Liong Lin
Summary: PHD inhibitors are effective in treating CKD-associated anemia by stabilizing HIF and increasing erythropoiesis. However, their impact on kidney fibrosis is inconsistent due to the context-dependent effects of HIF. Studies on pericytes suggest that HIF stabilization in these cells may not negatively affect kidney fibrosis despite increased erythropoietin production.
KIDNEY INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Jinwei Zhang, Xiaoqian Wu, Jideng Ma, Keren Long, Jing Sun, Mingzhou Li, Liangpeng Ge
Summary: Hypoxia and HIF signaling have important regulatory roles in cell biology, but their role in B cell biology is still controversial. Studies have found that hypoxia niches exist in different developmental stages of B cells, suggesting that hypoxia and HIF signaling may play a crucial role in the development, metabolism, and function of B cells. A better understanding of the role of hypoxia in B cell-mediated adaptive immunity could provide new strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Computer Science, Artificial Intelligence
Tahmid Hasan Pranto, Abdulla All Noman, Asaduzzaman Noor, Ummey Habiba Deepty, Rashedur M. Rahman
Summary: The volume and availability of satellite image data have increased significantly in recent years, but noise during transmission and acquisition poses a challenge. This study explores the impact of label noise on the performance of a semantic segmentation model, specifically U-Net. Different types of label noise are introduced, and their effects on the model's performance are analyzed.
APPLIED ARTIFICIAL INTELLIGENCE
(2022)
Review
Agriculture, Multidisciplinary
Md Sazan Rahman, Sarah MacPherson, Mark Lefsrud
Summary: Green roof technology can mitigate urbanization's adverse effects through stormwater control, water purification, and energy savings. However, challenges exist in terms of cost and maintenance for hydroponic green roofs. A novel extensive hydroponic green roof design using porous concrete as a plant-growth substrate and structural layer is proposed to address these challenges. It offers stormwater and pollution control, thermal benefits, and biomass production.
RENEWABLE AGRICULTURE AND FOOD SYSTEMS
(2022)
Article
Computer Science, Theory & Methods
Md. Manzurul Hasan, Debajyoti Mondal, Md. Saidur Rahman
Summary: This paper investigates the positive and planar 3-SAT problem and its variants, providing proofs on satisfiability and complexity properties under certain constraints.
THEORETICAL COMPUTER SCIENCE
(2022)
Article
Environmental Sciences
Zakaria Shams Siam, Rubyat Tasnuva Hasan, Soumik Sarker Anik, Fahima Noor, Mohammed Sarfaraz Gani Adnan, Rashedur M. Rahman, Ashraf Dewan
Summary: This study presents a novel flood risk assessment framework using a hybridized deep neural network and fuzzy analytic hierarchy process models. It is applied in Bangladesh, and the results show that the framework can generate accurate flood risk maps. The study also identifies high-risk areas in Bangladesh, particularly in the northeast region and areas adjacent to the Ganges-Brahmaputra-Meghna rivers.
GEOCARTO INTERNATIONAL
(2022)
Article
Engineering, Environmental
Lailatul Nehar, Tanvir Rahman, S. S. Tuly, Md Sazan Rahman, M. R. I. Sarker, M. R. A. Beg
Summary: Solar distillation is a cost-effective and low-energy desalination process that can produce potable water. By modifying the absorber plates and adding a condenser, the productivity and efficiency of the system can be increased, resulting in higher economic benefits.
GROUNDWATER FOR SUSTAINABLE DEVELOPMENT
(2022)
Article
Construction & Building Technology
Md Sazan Rahman, Tristan Chauvin-Bosse, Abdolhamid Akbarzadeh, Alexandre Guerini, Julien Chapelat, Mark Lefsrud
Summary: The study investigates the potential of using porous concrete with embedded heating and cooling coils as a building material. The results demonstrate that this new system has the ability to maintain a constant indoor temperature, regardless of outdoor temperature and relative humidity, making it energy-efficient and versatile.
BUILDING AND ENVIRONMENT
(2022)
Article
Mathematics, Applied
Md Manzurul Hasan, Shaheena Sultana, Md Saidur Rahman
Summary: This paper introduces a sliding column model for t-unit bar visibility representation and proves that graphs with maximum degree Delta can have t-unit bar visibility representation. Additionally, it demonstrates that planar graphs with maximum degree 3 and 3-connected cubic graphs can have unit bar visibility representation on specific numbers of columns.
DISCRETE MATHEMATICS ALGORITHMS AND APPLICATIONS
(2023)
Article
Computer Science, Information Systems
Sheikh Azizul Hakim, Bishal Basak Papan, Md. Saidur Rahman
Summary: This paper investigates the properties of pairwise compatibility graphs (PCGs) and proves that grid graphs are PCGs. It also identifies intermediate classes of graphs that are not PCGs, despite satisfying some of the necessary and sufficient conditions.
INFORMATION PROCESSING LETTERS
(2022)
Article
Green & Sustainable Science & Technology
Md Sazan Rahman, Sarah MacPherson, Abdolhamid Akbarzadeh, Alexandre Guerini, Julien Chapelat, Mark Lefsrud
Summary: In this study, a novel vegetation-covered bio-receptive porous concrete prototype was tested for its HVAC control capacity. The results showed that the vegetated porous concrete had the ability to heat, cool, humidify, and dehumidify, with passive dehumidification without external energy. This permeable building material has potential applications in green infrastructure and green wall systems.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Computer Science, Information Systems
A. A. Talha Talukder, Md Anisul Islam Mahmud, Arbiya Sultana, Tahmid Hasan Pranto, A. K. M. Bahalul Haque, Rashedur M. Rahman
Summary: Food delivery systems have become increasingly popular due to the expansion of internet connectivity and device availability. However, concerns arise regarding information security, deep discounting race between businesses, and strict policy enforcement. To address these issues, this paper proposes a blockchain and smart contract-based food delivery system aimed at eliminating commission schemes and reducing service delays caused by a high volume of orders.
JOURNAL OF INFORMATION AND TELECOMMUNICATION
(2022)
Article
Construction & Building Technology
Md Sazan Rahman, Sarah MacPherson, Mark Lefsrud
Summary: Greenhouse overheating is a major issue faced by dry climate agricultural setups during the summer. This study tested porous concrete as a novel evaporative cooling pad material, which showed the highest evaporative cooling capacity compared to conventional materials. The porous concrete demonstrated a cooling coefficient of 10.17 kW m-2 degrees C-1 and an evaporation rate of 5.84 g s-1.
BUILDING AND ENVIRONMENT
(2023)
Article
Environmental Sciences
Mohammed Sarfaraz Gani Adnan, Zakaria Shams Siam, Irfat Kabir, Zobaidul Kabir, M. Razu Ahmed, Quazi K. Hassan, Rashedur M. Rahman, Ashraf Dewan
Summary: Many studies have been conducted globally on machine learning-based flood susceptibility modeling. These models produce reasonably accurate flood predictions, but there is uncertainty in the spatial predictions. This study presents a framework for reducing spatial disagreement among different machine learning models and improving prediction accuracy.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Computer Science, Information Systems
Md. Anisul Islam Mahmud, A. A. Talha Talukder, Arbiya Sultana, Kazi Iftesam Amin Bhuiyan, Md. Samiur Rahman, Tahmid Hasan Pranto, Rashedur M. Rahman
Summary: The growing popularity of online news has raised concerns about the socio-political influence on news dissemination, decreasing freedom of news media, and an easy news evaluation process. To address these challenges, this paper proposes a blockchain, smart contract, and incremental machine learning-based news evaluation procedure for the Bengali language. A weighted synthesis of machine classification and human expert opinion on a decentralized platform is used to evaluate news. The Natural Language Processing (NLP) model is incrementally trained with continuous data to detect unreliable fake news. Experimental results show an increase in accuracy from 84.94% and 84.99% to 93.75% and 93.80% after nine rounds of incremental model training. The protocols have been successfully implemented and tested on the Ethereum test network.
Article
Multidisciplinary Sciences
Md Mostafizur Rahman, Mohammad Sohelur Rahman, Md Harunor Rashid Khan, Selina Yeasmin
Summary: Humans are exposed to radiation from various sources, including medical applications. Improper handling of radiation equipment and sources can pose health risks to radiation workers and the public. A study conducted in Bangladesh found that radiation levels around major hospitals were higher than the global average, emphasizing the importance of radiation monitoring to minimize public radiation risk and maintain radiation-free hospital environments.
Article
Biochemical Research Methods
Muhammad Ali Nayeem, Naser Anjum Samudro, M. Saifur Rahman, M. Sohel Rahman
Summary: In this study, a framework called MAMMLE is proposed to infer better phylogenetic trees from unaligned sequences by hybridizing two MSA tools (MUSCLE and MAFFT) with multiobjective optimization strategy and multiple maximum likelihood hypotheses. Experimental results show that MAMMLE exhibits a median improvement of 5.57% over MUSCLE in 50.34% of instances.
JOURNAL OF COMPUTATIONAL BIOLOGY
(2023)