Journal
BIOLOGICALS
Volume 39, Issue 3, Pages 167-170Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biologicals.2011.04.001
Keywords
Yellow fever vaccine; Seeds; Neurovirulence
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The results of tests of the neurovirulence of three yellow fever vaccine preparations of different lineages are presented. Two preparations that have been used to make vaccines of acceptable safety and efficacy gave very similar results. A third preparation from the Robert Koch Institute, designated 168-73, was proposed as a reference preparation for the mouse potency assay in 1985 by WHO, but has been more often used as a reference in the monkey neurovirulence test. In the test described here 168-73 was of lower virulence than either of the other two preparations. (C) 2011 The International Alliance for Biologicals. Published by Elsevier Ltd. All rights reserved.
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