Article
Neurosciences
Kerri Miller, Patrick L. Day, Supriya Behl, Lindsay Stromback, Adriana Delgado, Paul J. Jannetto, Michael E. Wieser, Sunil Q. Mehta, Mukesh K. Pandey
Summary: In order to understand the role of zinc and copper in autism spectrum disorder (ASD), the isotopic composition of serum zinc and copper was evaluated in healthy children and children with ASD in North America. No significant differences were found in isotopic composition between healthy controls and ASD children. However, the isotopic composition of serum copper in boys was enriched in Cu-65 compared to previously published healthy adult copper isotopic composition. Additionally, the average isotopic composition of serum zinc was heavier than that of healthy adults in both boys and girls. There was also a negative association between total zinc concentrations and zinc isotopic composition in boys.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Psychiatry
Keith A. Kwan Cheung, Murray D. Mitchell, Helen S. Heussler
Summary: Medicinal cannabis has shown promising results in treating neurodevelopmental and neuropsychiatric disorders, with cannabidiol being reported as safe and well-tolerated, offering anticonvulsant, anxiolytic, and anti-inflammatory properties. Research suggests that the endocannabinoid system plays a crucial role in neural development and health, opening up possibilities for improved treatments for these disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Kelsie A. Boulton, Adam J. Guastella, Marie-Antoinette Hodge, Eleni A. Demetriou, Natalie Ong, Natalie Silove
Summary: Children with neurodevelopmental conditions attending developmental assessment services have high rates of mental health concerns, with approximately 48% of preschool and 61% of school-age children having subclinical or clinically elevated scores. These rates remain high even after excluding items specifically related to neurodevelopmental concerns. School-aged females are more likely to have elevated internalizing problems compared to males (67% vs 48%). Children with multiple DSM-5 diagnoses also show a greater rate of subclinical or clinically elevated scores. These findings highlight the importance of identifying and addressing mental health concerns in children attending developmental assessment services.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Umme Raihan Siddiqi, Shelina Begum, Shorifa Shahjadi, Sharmin Afroz, Syeda Nusrat Mahruba, Jobaida Parvin, Md Mahbubur Rahman
Summary: This study found that there were significant differences in the levels of zinc and copper in the blood of Bangladeshi ASD children compared to healthy controls, with lower levels of zinc and higher levels of copper and the antioxidant protein ceruloplasmin in ASD children.
Article
Pediatrics
Elizabeth J. Halstead, Anna Joyce, Emma Sullivan, Carwyn Tywyn, Kyle Davies, Alexandra Jones, Dagmara Dimitriou
Summary: The study evaluated sleep disturbances and patterns in a large sample of children with NDC, finding differences between age, diagnosis, and medication groups, with sensory conditions linked to longer night time waking duration. Short sleep duration was commonly reported as a problem by parents.
FRONTIERS IN PEDIATRICS
(2021)
Article
Environmental Sciences
D. Hamoutene, K. Hua, A. Lacoursiere-Roussel, F. Page, S. M. Baillie, L. Brager, F. Salvo, T. Coyle, K. Chernoff, M. Black, D. Wong, E. Nelson, T. Bungay, D. Gaspard, E. Ryall, C. W. Mckindsey, T. F. Sutherland
Summary: The study conducted sediment sampling at finfish farms in three distinct Canadian regions and identified several trace elements, including Cu, Zn, Cd, Mo and U, as indicators of finfish aquaculture organic enrichment. Multivariate analyses showed a consistent clustering of these tracers with sediment organic matter and/or total dissolved sulfides concentrations. Organic matter content was found to be a predictor of the concentrations of these elements according to decision tree analyses. Distance from cages did not significantly impact the differences among sampling points.
MARINE POLLUTION BULLETIN
(2021)
Review
Nutrition & Dietetics
Priscila Kelly da Silva Bezerra do Nascimento, David Franciole Oliveira Silva, Tassia Louise Sousa Augusto de Morais, Adriana Augusto de Rezende
Summary: This review aimed to summarize scientific evidence on the relationship between zinc status and Autism Spectrum Disorder (ASD) in children and adolescents. A total of 52 studies were included, with 19 studies showing lower zinc concentrations in the ASD group. However, overall, there was no significant difference in zinc concentrations between children and adolescents with ASD compared to controls. More prospective studies with greater methodological rigor are needed to further characterize this relationship.
Article
Psychology, Developmental
Kay H. Y. Wong, Kathy Y. S. Lee, Sharon C. Y. Tsze, Wilson S. Yu, Iris H. -Y. Ng, Michael C. F. Tong, Thomas Law
Summary: This study compared the early pragmatic language skills of typically developing children, children with language impairment, and children with autism spectrum disorder. Results showed significant pragmatic language deficits in both clinical groups, with older children in the ASD group exhibiting impairments comparable to their LI peers. The findings also supported the use of direct assessment in identifying pragmatic language deficits, with implications for clinical settings.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Behavioral Sciences
Sebastian Ludyga, Uwe Puhse, Markus Gerber, Keita Kamijo
Summary: Research suggests that regular exercise can improve children's executive function and has the potential for use in treating executive dysfunction. Despite the heterogeneity of symptoms in neurodevelopmental disorders, exercise is beneficial for improving executive function deficits. However, key research questions need to be addressed before recommending exercise as a treatment for executive dysfunction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Pilar Martin-Borreguero, Antonio Rafael Gomez-Fernandez, Maria Jose De la Torre-aguilar, Mercedes Gil-Campos, Katherine Flores-Rojas, Juan Luis Perez-Navero
Summary: This study investigated the presence of neurodevelopmental regression in children with autism spectrum disorder (ASD) and its impact on clinical manifestations and severity of ASD. The results showed that children with neurodevelopmental regression had more severe autistic symptoms and lower overall neurodevelopment. Additionally, at 24 months follow-up, the neurodevelopmental regression subgroup had poorer scores on various tests compared to the non-regression subgroup.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Jessica A. Burket, Jason D. Webb, Stephen Deutsch
Summary: The free concentrations of redox reactive metals iron and copper are highly regulated due to their ability to catalyze the generation of toxic free radicals. The perineuronal net, a specialized component of brain extracellular matrix, not only binds metal cations for protective function but also supports fast-spiking electrophysiological properties of surrounding neurons.
Article
Psychology, Multidisciplinary
Yiwei Yang, Shi Zhao, Meihui Zhang, Mi Xiang, Jian Zhao, Shucheng Chen, Hui Wang, Lefei Han, Jinjun Ran
Summary: Based on the data from the National Health Interview Survey, we estimated the prevalence of attention-deficit/hyperactivity disorder, autism spectrum disorder, intellectual disorder, and learning disability among US children and adolescents aged 3-17 years in 2019 and 2020. The study found that the prevalence of these neurodevelopmental disorders varied by demographics, comorbidity/mental problems, household/parental characteristics, and stressful life events.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Environmental Sciences
Frances J. Charters, Thomas A. Cochrane, Aisling D. O'Sullivan
Summary: The study collected untreated runoff from different impermeable surfaces to quantify the differences in water quality due to surface type, age, condition, and location. Results showed that zinc and copper concentrations in runoff from zinc and copper roofs were significantly higher than water quality guidelines, indicating the importance of different removal processes for dissolved versus particulate metals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
T. Peter Stein, Margaret D. Schluter, Robert A. Steer, Xue Ming
Summary: This study investigated the glucuronidation efficiency of BPA and DEHP in children with ASD, ADHD and healthy controls. The results showed that both ASD and ADHD children had reduced glucuronidation efficiency for BPA and DEHP compared to controls, with the reduction for BPA being statistically significant.
Article
Psychology, Multidisciplinary
Laura Paulauskaite, Amanda Timmerman, Athanasia Kouroupa, Amanda Allard, Kylie M. Gray, Richard P. Hastings, David Heyne, Glenn A. Melvin, Bruce Tonge, Vasiliki Totsika
Summary: COVID-19 has had negative effects on children's education and mental health, but the study found that Elective Home Education (EHE) in families of children with neurodevelopmental conditions can provide personalized education and one-to-one support. Anxiety and mental health problems were similar between children participating in EHE and school-registered children.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Boukelia Boukhmis, Geir Bjorklund, Ibrahim H. Elkhidir, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Adekunle Hakeem Temitope, Sadaf Noor, Daniel-Ovidiu Costea
Summary: This systematic review and meta-analysis examined the effect of physical activity on weight loss in adults who underwent bariatric surgery. The study also compared biomarkers between individuals with different levels of physical activity after surgery. The results showed that BMI as a measure of physical activity had a positive impact on the target population. However, further larger-scale studies with stricter criteria are needed to confirm these findings.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Health Policy & Services
Yuliya Semenova, Varvara Trenina, Lyudmila Pivina, Natalya Glushkova, Yersin Zhunussov, Erlan Ospanov, Geir Bjorklund
Summary: This article summarizes the epidemiological characteristics and transmission modes of SARS-CoV, MERS-CoV, and SARS-CoV-2. Coronaviruses are likely to continue to be a source of acute respiratory infections in the future, therefore, it is important to enhance understanding of the factors underlying disease outbreaks and to develop strategic preparedness and plans of action. Public health interventions should be implemented to fight against these viruses.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2022)
Review
Biochemistry & Molecular Biology
Geir Bjorklund, Md Shiblur Rahaman, Mariia Shanaida, Roman Lysiuk, Petro Oliynyk, Larysa Lenchyk, Salvatore Chirumbolo, Christos T. Chasapis, Massimiliano Peana
Summary: Long-term exposure to arsenic compounds can lead to the accumulation of arsenic in the body, resulting in skin lesions and cancer. Treating arsenic poisoning is challenging, with no specific and safe therapeutic management available. Natural dietary compounds show potential effectiveness and progress in alleviating arsenic toxicity.
Article
Neurosciences
Nagwa A. Meguid, Heba S. Hashem, Mohamed H. Ghanem, Samia A. Helal, Yuliya Semenova, Saher Hashem, Adel Hashish, Salvatore Chirumbolo, Ahmed M. Elwan, Geir Bjorklund
Summary: This study aimed to identify metabolic abnormalities in BCAAs and investigate the presence of epileptiform discharges in ASD patients. Results showed that various types of seizures can occur in ASD children and that ASD children have lower levels of BCAAs compared to neurotypical controls. Further research is needed to better understand ASD and evaluate the association between ASD, EEG changes, seizures, and BCAAs more reliably.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Review
Chemistry, Medicinal
Amin Gasmi, Pavan Kumar Mujawdiya, Amine Nehaoua, Mariia Shanaida, Yuliya Semenova, Salva Piscopo, Alain Menzel, Volodymyr Voloshyn, Olena Voloshyn, Volodymyr Shanaida, Geir Bjorklund
Summary: The obesity pandemic is a pressing public health concern, with a projected increase in the number of obese or overweight individuals by 2025. Current strategies for treating obesity focus on patient-centered approaches including diet, behavior, medication, and surgery. However, there is a need for novel and more effective pharmaceutical drugs to assist with lifestyle modifications and better manage obesity.
Review
Infectious Diseases
Yernar Amangelsin, Yuliya Semenova, Maryam Dadar, Mohamad Aljofan, Geir Bjorklund
Summary: Tetracycline, a widely used antibiotic, has become a serious threat to the environment due to overuse and weak degradation ability. It accumulates in the food chain, causing toxicity to microbial communities, promoting antibiotic resistance, and disrupting human intestinal flora.
Review
Chemistry, Medicinal
Amin Gasmi, Mariia Shanaida, Oleksandra Oleshchuk, Yuliya Semenova, Pavan Kumar Mujawdiya, Yana Ivankiv, Olena Pokryshko, Sadaf Noor, Salva Piscopo, Stepan Adamiv, Geir Bjorklund
Summary: The immune system protects the body from infectious agents, and a well-balanced immunity is crucial for maintaining human health. Nutritional and micronutrient deficiencies can compromise the immune system, while certain bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources have shown immunomodulatory properties and can enhance the immune response.
Review
Health Care Sciences & Services
Laura Kassym, Assiya Kussainova, Yuliya Semenova, Almas Kussainov, Damir Marapov, Marat Zhanaspayev, Zhanar Urazalina, Almira Akhmetova, Madi Tokanov, Yerbol Smail, Geir Bjorklund
Summary: Drunk driving is a significant risk factor for traffic accidents and their lethality. This meta-analysis provides estimates of the prevalence of drunk driving in non-lethally injured drivers, considering factors such as the world region, blood alcohol concentration, and study quality. The pooled prevalence of drunk driving in injured drivers was found to be 16.6%.
Article
Health Policy & Services
Valeriy Zub, Yuliya Semenova, Oleksandr Tolstanov, Andrii Kotuza, Taras Gutor, Oksana Matsyura, Roman Lysiuk, Geir Bjorklund
Summary: This study assessed the challenges faced by oncologists in providing cancer care in Ukraine after the armed conflict. The findings showed that physicians in regions occupied by the Russian army experienced a significant decline in patient numbers, while most physicians were satisfied with the availability of medicines and equipment.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Neurosciences
Neluwa-Liyanage R. Indika, Udara D. Senarathne, Antonio Malvaso, Dhanushka Darshana, Susan C. Owens, Borhan Mansouri, Yuliya Semenova, Geir Bjorklund
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social interaction and communication deficits, along with repetitive and restricted patterns of activities, behavior, and interests. Heavy metal exposure, abnormal metabolism, and genetic susceptibility may play a role in the pathogenesis of ASD. Altered porphyrin metabolism in ASD may be associated with deficiencies in vitamins and minerals, and potential metabolic therapies such as supplementation with vitamins, minerals, cofactors, and antioxidants need to be explored in future research.
MOLECULAR NEUROBIOLOGY
(2023)
