Article
Oncology
Michael Cangkrama, Huan Liu, James Whipman, Maria Zubair, Mai Matsushita, Michela Di Filippo, Manfred Kopf, Metello Innocenti, Sabine Werner
Summary: This study reveals the crucial role of mitochondria in the protumorigenic CAF phenotype and identifies the activin A-mDia2-MIRO1 signaling axis as a potential diagnostic and therapeutic target in CAFs.
Article
Neurosciences
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Summary: The ATP7A(M1311V) variant results in abnormal localization of copper transporter, leading to intracellular copper accumulation, cell death, morphological and functional deficits of motor neurons, and even motor deficits.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Atsushi Shimoyama, Flaviana Di Lorenzo, Haruki Yamaura, Keisuke Mizote, Angelo Palmigiano, Molly D. Pither, Immacolata Speciale, Tomoya Uto, Seiji Masui, Luisa Sturiale, Domenico Garozzo, Koji Hosomi, Naoko Shibata, Kazuya Kabayama, Yukari Fujimoto, Alba Silipo, Jun Kunisawa, Hiroshi Kiyono, Antonio Molinaro, Koichi Fukase
Summary: The study characterized the structure of lipooligosaccharide (LOS) and lipopolysaccharide (LPS) from Alcaligenes faecalis. The hexaacylated A. faecalis lipid A was found to have moderate agonistic activity towards TLR4-mediated signaling and the ability to induce interleukin-6 release, making it a promising vaccine adjuvant candidate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Raul Ventura, Inma Martinez-Ruiz, Maria Isabel Hernandez-Alvarez
Summary: Phospholipids are essential components of eukaryotic membranes and play a crucial role in cell organelles. The synthesis and transport of phospholipids are important for maintaining cellular functions, and their dysfunction can lead to various diseases.
Article
Genetics & Heredity
Lida Omaleki, Patrick J. Blackall, Thom Cuddihy, Rhys T. White, Jodi M. Courtice, Conny Turni, Brian M. Forde, Scott A. Beatson
Summary: This study investigates the outbreak dynamics of fowl cholera caused by Pasteurella multocida by using whole-genome sequencing and phylogenomic analysis. The analysis reveals a high degree of genetic diversity in the lipopolysaccharide outer core biosynthesis loci, indicating potential reasons for the repeated vaccination failures. The study also identifies potential phase variation mechanisms and emphasizes the importance of selecting appropriate vaccine strains based on the predicted LPS structure.
MICROBIAL GENOMICS
(2022)
Article
Microbiology
Emily A. Lundstedt, Brent W. Simpson, Natividad Ruiz
Summary: The LPS transport machine composed of LptB(2)FGC forms a transenvelope bridge for the rapid transport of LPS from the inner membrane to the outer membrane. Genetic analyses in Escherichia coli revealed bidirectional coupling across cellular compartments during LPS transport, which could be exploited in developing antimicrobials to overcome the permeability barrier imposed by LPS.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Kensuke Akamatsu, Shu-ichi Nakano, Koshi Kimura, Yohei Takashima, Takaaki Tsuruoka, Hidemi Nawafune, Yuki Sato, Junya Murai, Hiroshi Yanagimoto
Summary: The development of high-performance, environmentally friendly electro-deposition processes is critical, and the use of a polyelectrolyte membrane effectively concentrates metal ions for solid-state electrodeposition without mist, sludge, or waste effluent, offering a new ion transport mechanism.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Gastroenterology & Hepatology
Sofia Moran-Ramos, Daniel Cerqueda-Garcia, Blanca Lopez-Contreras, Elena Larrieta-Carrasco, Hugo Villamil-Ramirez, Selene Molina-Cruz, Nimbe Torres, Monica Sanchez-Tapia, Rogelio Hernandez-Pando, Carlos Aguilar-Salinas, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
Summary: This study aimed to characterize the gut microbiome composition of patients with obesity and biopsy-proven NAFLD. The study found that Parabacteroides distasonis and Alistipes putredenis were enriched in fatty liver patients but not in NASH patients. Furthermore, individuals with a Prevotella copri dominant bacterial community were more likely to develop NASH, possibly due to higher intestinal permeability and lower capacity for butyrate production.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Microbiology
Yuan Qiao, Zhichun Zhang, Yuanyuan Zhai, Xu Yan, Wenling Zhou, Hao Liu, Lingling Guan, Liang Peng
Summary: The gut microbiota plays a crucial role in the development of obesity and related metabolic disorders. Apigenin (Api), a flavonoid found in fruits and vegetables, has shown anti-obesogenic and anti-inflammatory properties. This study demonstrates that Api supplementation can improve gut dysbiosis and restore gut barrier damage in obese mice, leading to reduced body weight and improved metabolic health.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vincenzo Mangini, Benny Danilo Belviso, Maria Incoronata Nardella, Giovanni Natile, Fabio Arnesano, Rocco Caliandro
Summary: The bioavailability of copper in human cells may be influenced by the presence of zinc ions. This study demonstrates that zinc ions can target the Cu-chaperone Atox1 and deliver it to Cu-transporting ATPases. The crystal structure of Atox1 loaded with zinc confirms the presence and location of the zinc ion. These findings suggest a potential interplay between Cu and Zn transport mechanisms in human cells.
Article
Plant Sciences
Zhenjing Ren, Kaijian Fan, Sihan Zhen, Jie Zhang, Yan Liu, Junjie Fu, Chunlai Qi, Qianhan Wei, Yao Du, Wurinile Tatar, Xiaofeng Zhang, Guoying Wang, Allan G. Rasmusson, Jianhua Wang, Yunjun Liu
Summary: The maize gene SMK11 encodes a mitochondria-localized tetratricopeptide repeat protein, which plays critical roles in the assembly and activity of mitochondrial complex IV, and is essential for seed development.
Article
Plant Sciences
Paul Rosas-Santiago, Karla Zechinelli Perez, Maria Fernanda Gomez Mendez, Francisco Vera Lopez Portillo, Jorge Luis Ruiz Salas, Elizabeth Cordoba Martinez, Alexis Acosta Maspon, Omar Pantoja
Summary: Physcomitrella patens, a moss, provides genetic information on early Embryophytes' adaptation to land life with two COPT proteins playing different roles in copper homeostasis. PpaCOPT1 and PpaCOPT2 restored growth in yeast at micromolar Cu concentrations, with PpaCOPT1 expressed in different locations compared to PpaCOPT2.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Chemistry, Physical
Like Huang
Summary: Since the invention of solar cells, thermodynamics has been used to evaluate their efficiency and explore advancements in materials science and photovoltaic technology. By addressing thermodynamic efficiency losses, ultrahigh efficiency photovoltaic cells can be achieved. This study focuses on the energy band edge electronic density of states (DOS) and its impact on device performance. It reveals the significance of DOS engineering and its potential to improve solar cell devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Food Science & Technology
Remigio Pismag, Joana Pico, Alejandro Fernandez, Jose Luis Hoyos, Mario M. Martinez
Summary: This study aimed to enhance protein digestibility in saponin-free quinoa flour while minimizing polyphenol losses by optimizing an integrated single-step process exploiting the synergisms of amylolysis and extrusion. The results showed significant improvement in in vitro protein digestion rate and extension with each extrusion treatment, but also an increase in thermoresistant bound polyphenols.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Neuroimaging
Kyoungjune Pak, Keunyoung Kim, Seongho Seo, Myung Jun Lee, In Joo Kim
Summary: This study found that glucose loading may alter the availability of serotonin transporter (SERT) in the human brainstem, and SERT availability was negatively correlated with body mass index (BMI) after glucose loading.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Pharmacology & Pharmacy
Quanwei Zhang, Zhexuan Lin, Xiukai Yin, Lingzhi Tang, Hongjun Luo, Hui Li, Yuan Zhang, Wenhong Luo
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Review
Pharmacology & Pharmacy
Zhexuan Lin, Quanwei Zhang, Wenhong Luo
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ming Han, Shan Ding, Yuan Zhang, Zhexuan Lin, Kangsheng Li
BIOLOGICAL TRACE ELEMENT RESEARCH
(2018)
Article
Urology & Nephrology
Jinwan Shi, Jiuzhan Qian, Hui Li, Hongjun Luo, Wenhong Luo, Zhexuan Lin
Article
Biochemistry & Molecular Biology
Wenhao Lin, Wei Han, Ke Wen, Sunhua Huang, Yao Tang, Zhexuan Lin, Ming Han
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Xuyang Chen, Hui Li, Hongjun Luo, Zhexuan Lin, Wenhong Luo
Article
Critical Care Medicine
Sunhua Huang, Yao Tang, Wenhao Lin, Ke Wen, Wei Han, Zhexuan Lin, Ming Han
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2020)
Article
Critical Care Medicine
Yao Tang, Sunhua Huang, Wenhao Lin, Ke Wen, Zhexuan Lin, Ming Han
Summary: Through studying a rat model of TIC caused by multiple injuries, it was found that the inhibition rate of the AA-dependent pathway increased significantly after injury, leading to platelet dysfunction. The plasma concentrations of 6-Keto-PGF(1α) and PGE(2) also increased accordingly.
Article
Biochemistry & Molecular Biology
Wenhao Lin, Zhexuan Lin, Yao Tang, Ke Wen, Sunhua Huang, Ming Han
Summary: Nutritional and inflammatory status differed significantly in patients with acute appendicitis, with serum zinc levels correlating with albumin, total protein, neutrophil count, and neutrophil-lymphocyte ratio.
TRACE ELEMENTS AND ELECTROLYTES
(2021)
Article
Pharmacology & Pharmacy
Peijian Wang, Hui Li, Zhexuan Lin, Hongjun Luo, Wenhong Luo
Summary: In this study, it was found that silepcimide (ILE) can improve the bioavailability of curcumin (CUR). Repeated administration of piperine (PIP) or ILE significantly increased the plasma concentration of the metabolite. The metabolic pathway of CUR was investigated, indicating that gastrointestinal microorganisms may play a role in the transformation of CUR to its metabolite.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mingxin Ye, Hui Li, Hongjun Luo, Yongyin Zhou, Wenhong Luo, Zhexuan Lin
Summary: This study found that erythrocytes metabolize methionine to homocysteine, which enhances the antioxidative capability of erythrocytes and protects them against damage from reactive oxygen species.
Article
Biochemical Research Methods
Kaisong Yuan, Rui Huang, Kaishuo Gong, Ziyi Xiao, Jialin Chen, Siyao Cai, Jiayi Shen, Zuer Xiong, Zhexuan Lin
Summary: Smartphone-based hand-held polarized light microscope is a compact, portable, and low-cost method for pharmaceutical crystallinity characterization. It has high resolution, imaging quality, and flexibility for on-site applications. This device has great potential in helping pharmacists for both research purposes and on-site drug testing.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biology
Long Su, Zhexuan Lin, Hui Li, Hongjun Luo, Wenhong Luo
Summary: Divicine can cause damage to endothelial cells, and ferroptosis may be involved in the injury of HUVECs induced by divicine. Long-term ingestion of fava beans may be harmful to the vascular system, especially for those suffering from glucose-6-phosphate dehydrogenase deficiency.
Article
Spectroscopy
Zhang Yuan, Wu Peng, Li Hui, Luo Hong-jun, Luo Wen-hong, Lin Zhe-xuan
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2020)
Article
Spectroscopy
Zhang Yuan, Lin Zhe-xuan, Han Ming
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2017)
