Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 150, Issue 1-3, Pages 337-341Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-012-9504-8
Keywords
Neurotoxicity; Brain; Manganese; gamma-Aminobutyric acid (GABA); Glutamate; Amino acids
Funding
- FCT (Foundation for Science and Technology of Portugal) [SFRH/BD/64128/2009]
- i-Med.UL, Faculty of Pharmacy, University of Lisbon
- National Institute of Environmental Health Sciences [ES R01 10563]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/64128/2009] Funding Source: FCT
Ask authors/readers for more resources
Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism. Excessive exposure to Mn can lead to poisoning, characterized by psychiatric disturbances and an extrapyramidal disorder. Mn-induced neuronal degeneration is associated with alterations in amino acids metabolism. In the present study, we analyzed whole rat brain amino acid content subsequent to four or eight intraperitoneal injections, with 25 mg MnCl2/kg/day, at 48-h intervals. We noted a significant increase in glycine brain levels after four or eight Mn injections (p < 0.05 and p < 0.01, respectively) and arginine also after four or eight injections (p < 0.001). Significant increases were also noted in brain proline (p < 0.01), cysteine (p < 0.05), phenylalanine (p < 0.01), and tyrosine (p < 0.01) levels after eight Mn injections vs. the control group. These findings suggest that Mn-induced alterations in amino acid levels secondary to Mn affect the neurochemical milieu.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available