Article
Chemistry, Analytical
Magdalena Z. Wiloch, Martin Jonsson-Niedziolka
Summary: Alzheimer's disease is a neurodegenerative disease with oxidative stress as a major factor in its pathogenesis. Cu(II) ions complexed with Aβ peptides can facilitate the production of reactive oxygen species. Dehydration of glutamic acid in Aβ leads to weaker Cu(II) stabilization. The presence of phosphate ions in the electrolyte affects the redox properties of the complex.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Cell Biology
Lucia Recinella, Maria Loreta Libero, Serena Veschi, Anna Piro, Guya Diletta Marconi, Francesca Diomede, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Rosalba Florio, Alessia Lamolinara, Renzhi Cai, Wei Sha, Andrew V. Schally, Roberto Salvatori, Luigi Brunetti, Sheila Leone, Markus Fendt
Summary: This study investigated the effects of a GHRH antagonist, MIA-602, on emotional disorders and explored the underlying mechanisms. The results showed that MIA-602 treatment and GHRH gene deficiency were associated with anxiolytic and antidepressant behavior. Additionally, the study found that MIA-602 treatment activated Nrf2, HO1, and NQO1, while downregulating COX-2, iNOS, NFkB, and TNF-alpha expressions. These findings suggest a dysregulation of neural pathways caused by GHRH gene deficiency, which is mimicked by GHRH antagonist treatment.
Article
Agriculture, Dairy & Animal Science
Hulong Lei, Qian Du, Naisheng Lu, Xueyuan Jiang, Mingzhou Li, Dong Xia, Keren Long
Summary: This study compared the effects of copper sulfate and copper glycinate on fecal microbiota and metabolites in pigs, and found that copper glycinate had more positive effects on gut health.
Article
Materials Science, Multidisciplinary
Huajie Tang, Jianlin Sun, Jinshan Pan
Summary: In this study, the electrochemical and localized corrosion behavior of a 316L SS/copper/316L SS composite in a 0.5 wt. % NaCl solution was investigated using electrochemical measurements and high-resolution microscopic examination. Galvanic coupling accelerated the dissolution at the internal surface and pitting attack at the external surface of the 316L layer. Polarization up to 1 V/SCE resulted in the formation of a corrosion product layer composed of metal oxides/hydroxides on top of the passive film.
Article
Biochemistry & Molecular Biology
Zsuzsanna Szabo, Eva Juhasz, Andrew Schally, Balazs Dezso, Sandor Huga, Zoltan Hernadi, Gabor Halmos, Csongor Kiss
Summary: This study investigates the expression of GHRH and its splice variant receptors in human endometrial carcinomas (ECs). The results show the presence of mRNA for GHRH and its splice variants in ECs, while normal endometrial tissue samples do not express these receptors. Additionally, high affinity GHRH receptors were found in EC specimens. These findings suggest the existence of an autocrine loop based on GHRH and its tumoral splice variant receptors in EC, and that the antiproliferative effects of GHRH antagonists on EC may be mediated by these local receptors.
Article
Environmental Sciences
Quanwei Li, Jianzhao Liao, Chaiqin Lei, Jian Shi, Hui Zhang, Qingyue Han, Jianying Guo, Lianmei Hu, Ying Li, Jiaqiang Pan, Zhaoxin Tang
Summary: The study found that exposure to copper can lead to significantly increased serum biochemical parameters in pigs, severe structural abnormalities in cardiomyocytes with high copper concentrations exposure, and specific changes in mRNA and protein expression levels in cardiomyocytes at day 80 of the trial.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Endocrinology & Metabolism
Manuel H. Aguiar-Oliveira, Roberto Salvatori
Summary: The study of isolated GH deficiency caused by a homozygous inactivating mutation in the GH releasing hormone receptor gene has shown a variety of phenotypic changes in body size and function, with a greater number of beneficial consequences.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Environmental Sciences
Maral Selin Findikoglu Ercan, Merve Firat Ayyildiz, Dotse Selali Chormey, Sezgin Bakirdere
Summary: A new method utilizing green switchable solvent-based liquid-phase microextraction was employed to detect copper accumulation in traditional copper coffee pots, with results showing high accuracy and precision.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2021)
Review
Oncology
Shima Mehrabadi, Mahla Velayati, Nima Zafari, Seyed Mahdi Hassanian, Majid Ghayour Mobarhan, Gordon Ferns, Majid Khazaei, Amir Avan
Summary: Gastrointestinal cancers are prevalent and have a poor prognosis worldwide, with no effective treatment currently available. The expression of GHRH and GHRH-R in various tumor tissues and cell lines has opened up a new area of research for potential cancer treatment. Recent studies have demonstrated the expression of GHRH and GHRH-R in different types of cancers, suggesting the potential use of GHRH antagonists for treatment. This review aims to summarize the recent studies on the relationship between GHRH and gastrointestinal cancers and evaluate its potential as a therapeutic target or prognostic marker.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Environmental Sciences
Chaiqin Lei, Jianzhao Liao, Quanwei Li, Jian Shi, Hui Zhang, Jianying Guo, Qingyue Han, Lianmei Hu, Ying Li, Jiaqiang Pan, Zhaoxin Tang
Summary: The accumulation of copper in the hypothalamus can cause mitochondrial dysfunction, induce mitochondria-mediated apoptosis, and activate the AMPK-mTOR pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Ruy A. Louzada, Manuel Blandino-Rosano, Sebastian Flores, Camila Lubaczeuski, Tengjiao Cui, Wei Sha, Renzhi Cai, Andrew V. Schally, Ernesto Bernal-Mizrachi
Summary: The GHRH agonist MR-409 has the potential to protect β-cells from damage caused by inflammatory cells and cytokines in T1D, and improve insulin secretion by activating the Akt signaling pathway through the induction of IRS2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Giuseppina Granato, Iacopo Gesmundo, Francesca Pedrolli, Ramesh Kasarla, Laura Begani, Dana Banfi, Stefania Bruno, Tatiana Lopatina, Maria Felice Brizzi, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V. Schally, Riccarda Granata
Summary: COVID-19 is characterized by excessive inflammation and macrophage hyperactivation, which can lead to lung injury and acute respiratory distress syndrome. Recent studies have shown that the spike protein of SARS-CoV-2 interacts with bacterial lipopolysaccharide (LPS) to enhance inflammatory responses. This study demonstrates that GHRH antagonist MIA-602 can reduce inflammation in THP-1-derived macrophages and PBMCs stimulated with S protein and LPS combination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renzhi Cai, Xianyang Zhang, Haibo Wang, Tengjiao Cui, Gabor Halmos, Wei Sha, Jinlin He, Petra Popovics, Irving Vidaurre, Chongxu Zhang, Mehdi Mirsaeidi, Andrew Schally
Summary: The AVR series of GHRH antagonists exhibit high anticancer activities with greater antitumor effects compared to previously reported MIAMI series. These analogs show strong binding affinities to membrane GHRH receptors and demonstrate potential for clinical therapy in various human cancers.
Article
Agriculture, Dairy & Animal Science
Laia Blavi, David Sola, Alessandra Monteiro, J. Francisco Perez, Hans H. Stein
Summary: The experiment showed that supplementing diets for growing pigs with Cu2O can improve growth performance and bone mineralization, with less copper accumulation in the liver compared to pigs fed diets containing CuSO4.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Danyel Bueno Dalto, Isabelle Audet, Caroline Roy, Aliny Ketilim Novais, Karine Deschene, Katherine Goulet, J. Jacques Matte, Jerome Lapointe
Summary: This study evaluated the effects of different doses of zinc oxide (100, 1,000, and 3,000 mg/kg) on zinc and copper metabolism in weaned piglets. The results showed that the addition of 3,000 mg of zinc oxide/kg of diet did not effectively regulate zinc levels in the tissues. Moreover, this dose of zinc oxide increased copper sequestration in the intestine and impaired its reabsorption in the kidney, negatively impacting the hepatic and systemic copper concentrations, potentially leading to detrimental effects on piglet growth.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Lei Liu, Hong Lu, Juan J. Loor, Ahmad Aboragah, Xiliang Du, Jianhua He, Tao Peng, Jianming Su, Zhe Wang, Guowen Liu, Xinwei Li
Summary: Susceptibility to mastitis is highest during the peri-partal period, with factors like ketosis exacerbating the condition. The study found that ketotic cows had lower levels of SIRT3 and higher activation of NF-Kappa B signaling in the mammary gland. This suggests that SIRT3 could be a promising target for alleviating localized inflammation in the mammary gland caused by exposure to high levels of NEFA.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Cell Biology
Xiaoyan Zhu, Jian Huang, Yongji Wu, Shanting Zhao, Xuejun Chai
Summary: This review summarizes the current understanding of inflammation-induced deficits in hippocampal neurogenesis and resulting behavioral impairments after heat stress. It provides insights into the molecular and cellular mechanisms underlying neuroinflammation-induced deficits in hippocampal neurogenesis, particularly in relation to cognitive dysfunction following heat stress. The review aims to identify potential mechanisms through which neuroinflammation induces cognitive dysfunction and elucidate the contribution of neuroinflammation to defective hippocampal neurogenesis.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cixia Li, Xuejun Chai, Jiarong Pan, Jian Huang, Yongji Wu, Yuhuan Xue, Wentai Zhou, Jiping Yang, Xiaoyan Zhu, Shanting Zhao
Summary: Hypoglycemia-induced brain damage is related to the accumulation of ROS. BHBA can protect cells under low glucose conditions by inhibiting ROS production and caspase-3 activation. These findings shed light on the anti-apoptotic effect of BHBA in a low-energy state.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jian Huang, Xuejun Chai, Yongji Wu, Yan Hou, Cixia Li, Yuhuan Xue, Jiarong Pan, Yongkang Zhao, Aimin Su, Xiaoyan Zhu, Shanting Zhao
Summary: Heat stress can lead to neuroinflammation and cognitive deficits. Treatment with p-Hydroxybutyric acid (BHBA) in mice can alleviate heat stress-induced neuroinflammation and cognitive dysfunction by inhibiting the activation of glial cells and modulating signaling pathways.
Article
Neurosciences
Yuhuan Xue, Xiaoyan Zhu, Wenyong Yan, Zhihan Zhang, Enhui Cui, Yongji Wu, Cixia Li, Jiarong Pan, Qijiang Yan, Xuejun Chai, Shanting Zhao
Summary: This study investigates the potential effects of Acer truncatum oil on remyelination in a cuprizone mouse model of demyelination. The results show that diet supplementation with Acer truncatum oil can attenuate demyelination induced by cuprizone, indicating that Acer truncatum oil may be a novel therapeutic diet for demyelinating diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Lei Liu, Baogen Wang, Wei Yang, Qianming Jiang, Juan J. Loor, Lu Ouyang, Huilun Tang, Renxu Chang, Tao Peng, Chuang Xu
Summary: Excessive inflammation in bovine mammary endothelial cells (BMEC) due to mastitis leads to disease progression and eventual culling of cattle. Sirtuin 3 (SIRT3), a mitochondrial deacetylase, downregulates pro-inflammatory cytokines in BMEC exposed to high concentrations of nonesterified fatty acids by blunting nuclear factor-KB (NFKB) signaling. The study investigated the effects of SIRT3 and PGC1 alpha on inflammatory responses in bovine mammary epithelial cells and confirmed the potential benefits of targeting SIRT3 to prevent or alleviate negative effects of mastitis.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shuai Wang, Fangyuan Zeng, Yue Ma, Jiaojiao Yu, Chenyao Xiang, Xiao Feng, Songlin Wang, Jianguo Wang, Shanting Zhao, Xiaoyan Zhu
Summary: The study found that strontium (Sr) has a protective effect on hippocampal damage in non-alcoholic fatty liver disease (NAFLD) mice. Sr can reduce the expression of caspase-3 by suppressing endoplasmic reticulum stress (ERS), and inhibit neuroinflammation and the expression of inflammatory cytokines, thereby alleviating NAFLD-induced hippocampal damage. This finding suggests that Sr could be a potential candidate for protecting against neural damage caused by NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Yan Huang, Yezi Kong, Bingyu Shen, Bowen Li, Juan J. Loor, Panpan Tan, Bo Wei, Linshan Mei, Zixin Zhang, Chenxu Zhao, Xiaoyan Zhu, Simeng Qi, Jianguo Wang
Summary: This study comprehensively assessed the metabolomic profiles of dairy goats with subclinical hyperketonemia (SCHK) and found that SCHK goats had higher concentrations of nonesterified fatty acids, beta-hydroxybutyrate, and aminotransferase, but lower glucose concentrations compared to clinically healthy goats. Pathway enrichment analysis revealed abnormalities in the citrate cycle, alanine, aspartate and glutamate metabolism, and phenylalanine metabolism in SCHK goats. Overall, the altered metabolites in SCHK goats indicated a more severe negative energy balance and an imbalance in the tricarboxylic acid cycle, lipid metabolism, and amino acid metabolism. These findings provide a more comprehensive understanding of the pathogenesis of SCHK in dairy goats.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Food Science & Technology
Cixia Li, Jiarong Pan, Penghao Sun, Shuai Wang, Songlin Wang, Wenyu Feng, Shulin Chen, Xuejun Chai, Shanting Zhao, Xiaoyan Zhu
Summary: The study investigates the role of gut microbiota regulation with a ketogenic diet (KD) in hypoglycemia-induced neuroinflammation. KD alleviates blood-brain barrier injury and brain edema induced by hypoglycemia. It modulates the gut microbiota by increasing Firmicutes and Proteobacteria abundance and decreasing Bacteroidetes abundance, leading to the alleviation of hypoglycemia-induced neuroinflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Enhui Cui, Pan Tang, Xiaoyan Zhu, Mengyuan Lv, Shuai Wang, Yuhuan Xue, Cixia Li, Shanting Zhao
Summary: This study investigated the immune-enhancing effect of Eucommia ulmoides leaf polysaccharide (ELP) in immunosuppressed mice induced by cyclophosphamide (CTX). The study found that ELP primarily consists of arabinose, galacturonic acid, galactose, rhamnose, and a small amount of glucose. ELP could significantly enhance the proliferation and phagocytosis of macrophages in vitro and protect immune organs and reduce pathological damage in vivo. Furthermore, ELP increased the production of inflammatory cytokines and up-regulated the expression of IL-1 beta, IL-6, and TNF-alpha mRNA levels.
Article
Clinical Neurology
Mengli Wang, Penghao Sun, Zhuoni Li, Jing Li, Xin Lv, Shulin Chen, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao
Summary: This study found that Eucommiae cortex polysaccharides (EPs) can improve stress-induced gut dysbiosis and alleviate intestinal inflammation, thus improving behavioral abnormalities. The perturbed gut microbiota and neuroinflammation are strongly correlated with behavioral abnormalities. However, the causal relationship between EPs remodeling the gut microbiota and improved behavior in stressed mice was not clarified.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Agriculture, Multidisciplinary
Renxu Chang, Hongdou Jia, Zhihao Dong, Qiushi Xu, Lei Liu, Zolzaya Majigsuren, Tugsjargal Batbaatar, Chuang Xu, Qing Yang, Xudong Sun
Summary: Early lactation increases metabolic stress in ketotic dairy cows, leading to mitochondrial damage, apoptosis, and inflammatory response in mammary epithelial cells. The Mito-ROS-NLRP3 pathway plays a key role in this inflammatory response and cell apoptosis. Understanding this pathway can help in managing ketosis in dairy cows.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Microbiology
Penghao Sun, Mengli Wang, Yong-Xin Liu, Luqi Li, Xuejun Chai, Wei Zheng, Shulin Chen, Xiaoyan Zhu, Shanting Zhao
Summary: This study found that a high-fat diet disrupts the interactions between gut microbiota and colonocytes, leading to dysfunction in the Trp-Kyn metabolism pathway. The high-fat diet promotes the expansion of Proteobacteria and activates the IDO1-mediated Kyn pathway, causing Trp depletion and Kyn accumulation in the circulation. However, supplementation with butyrate restores mitochondrial function and remodels the gut microbiota, improving serum Kyn accumulation.
Article
Medicine, Research & Experimental
Penghao Sun, Mengli Wang, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao
Summary: This study investigates the effects of an obesogenic diet on adolescents and explores the role of Eucommiae cortex polysaccharides in mitigating the diet-induced behavioral dysfunction. The study reveals that the supplementation of polysaccharides improves cognitive and social behavior by modulating gut microbiota and tryptophan metabolism in adolescent mice fed with the obesogenic diet.
Article
Veterinary Sciences
Dongmei Xing, Baogen Wang, Hong Lu, Tao Peng, Jianming Su, Hongyu Lei, Jianhua He, Yingfang Zhou, Lei Liu
Summary: The study found that SIRT3 can restore the synthesis and assembly of VLDL in cow hepatocytes challenged with high NEFA, providing an in vitro basis for further investigations testing its feasibility against hepatic TAG accumulation in dairy cows during the perinatal period.
VETERINARY SCIENCES
(2021)
