Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 129, Issue 1-3, Pages 94-98Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-008-8299-0
Keywords
Osteopenia/osteoporosis; Copper; ICP-MS; Bone mineral density; DEXA; QCT; Coeruloplasmin; Albumin; Certified biological reference materials
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Copper concentrations in blood plasma have been determined in 25 osteopenic females using inductively coupled plasma-mass spectrometry. A high degree of correlations has been demonstrated between the copper concentrations in plasma and the bone mineral density of the lumbar spine as measured using dual energy X-ray absorptiometry and quantitative computerized tomography. Results clearly indicate the involvement of copper in bone health and osteopenia. It is further suggested that plasma copper might be useful as a cheap and simple method indicative of bone mineral density in osteopenic postmenopausal females.
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