Article
Clinical Neurology
Peipei Wang, Qinghua Li, Xiaosong Dong, Haiyan An, Jing Li, Long Zhao, Han Yan, Kosuke Aritake, Zhili Huang, Kingman P. Strohl, Yoshihiro Urade, Jun Zhang, Fang Han
Summary: This study compared CSF and serum levels of LPGDS in patients with central hypersomnia and healthy controls. The results showed that LPGDS levels were significantly lower in control subjects compared to patients with EDS complaints, but there were no significant differences in L-PGDS levels between different types of hypersomnia. Serum L-PGDS correlated modestly and negatively with sleep latency in hypersomnia subjects.
Article
Health Care Sciences & Services
Evan A. Balmuth, Thomas E. Scammell
Summary: Harriet Tubman, a hero of the abolitionist movement, experienced sleep attacks and visions as a result of a head injury in her childhood. While her contemporaries attributed these experiences to her deep faith, modern understanding suggests that her sleep attacks may be more related to post-traumatic narcolepsy than temporal lobe epilepsy. This case study not only sheds light on Tubman's life but also allows for a review of long-term effects of traumatic brain injuries and provides insights into the pathophysiology, diagnosis, and treatment of narcolepsy.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Clinical Neurology
Makoto Honda, Yosuke Shigematsu, Mihoko Shimada, Yoshiko Honda, Katsushi Tokunaga, Taku Miyagawa
Summary: This study provides evidence that abnormal fatty acid metabolism is involved in the pathophysiology of narcolepsy type 1 (NT1) and other hypersomnia, shedding new light on the understanding of the underlying mechanisms of these disorders.
Review
Clinical Neurology
Ye Zhang, Rong Ren, Linghui Yang, Haipeng Zhang, Yuan Shi, Michael V. Vitiello, Xiangdong Tang, Larry D. Sanford
Summary: This meta-analysis examines the polysomnography (PSG) differences between narcolepsy type 1 (NT1)/type 2 (NT2) and idiopathic hypersomnia (IH), finding significant differences in sleep parameters between NT1 and IH, but not between NT2 and IH. The results suggest that NT1 exhibits shallower and more fragmented sleep compared to IH, while the sleep characteristics of NT2 and IH without long sleep time are very similar.
SLEEP MEDICINE REVIEWS
(2022)
Article
Clinical Neurology
Pauline Dodet, Camille Noiray, Smaranda Leu-Semenescu, Etienne Lefevre, Milan Nigam, Pauline Faucher, Jean-Baptiste Maranci, Christel Jublanc, Christine Poitou, Isabelle Arnulf
Summary: This study investigated the relationship between craniopharyngioma, sleep, and excessive need for sleep. Compared with the control group, patients with craniopharyngioma were more likely to be obese, had shorter sleep latency, and slept longer on the first night. Treatment with stimulants was effective in 90% of the patients.
Article
Clinical Neurology
Philipp O. Valko, Schirin Hunziker, Kevin Graf, Esther Werth, Christian R. Baumann
Summary: The study assessed the prevalence and correlates of sleep-wake misperception in a large cohort of patients with various sleep-wake disorders. Significant differences were found in the magnitude of under-and overestimation of total sleep time between distinct diagnostic groups.
Article
Clinical Neurology
Sajni Gudka, Emma Haynes, Joanne Scotney, Sutapa Mukherjee, Simon Frenkel, Sheila Sivam, John Swieca, Ksenia Chamula, David Cunnington, Bandana Saini
Summary: Patients with narcolepsy often experience comorbidities related to emotional, metabolic, sleep, and immune health, which significantly impact their quality of life and clinical outcomes. This review aims to enhance understanding of the complex presentations by exploring the literature on comorbidities in narcolepsy patients and encourages a multidisciplinary approach to improve clinical and quality of life outcomes.
SLEEP MEDICINE REVIEWS
(2022)
Article
Clinical Neurology
Axel Bornstein, Anders Hedstrom, Pontus Wasling
Summary: This study investigated whether reduced physical activity could explain weight gain in NT1 patients, but no significant differences were found in physical activity levels or total energy expenditure when analyzing accelerometric data.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Pediatrics
I-Hang Chung, Wei-Chih Chin, Yu-Shu Huang, Chih-Huan Wang
Summary: Pediatric narcolepsy is a common chronic sleep disorder in children, and early diagnosis and intervention are crucial for children's development. The comprehensive treatment approach includes medication, behavioral modification, and education/mental support.
Review
Clinical Neurology
Michel Billiard, Karel Sonka
Summary: Idiopathic hypersomnia, first described in 1976, has undergone multiple name changes and descriptions over the years, but still lacks clear diagnostic criteria. Recent research has proposed dividing idiopathic hypersomnia into subtypes based on long sleep duration or the absence of it.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Clinical Neurology
A. Romigi, M. Caccamo, F. Testa, D. Ticconi, S. Cappellano, B. Di Gioia, G. Vitrani, I. Rosenzweig, D. Centonze
Summary: This study aimed to determine the changes in muscle tone (atonia index, AI) at different levels of vigilance during the multiple sleep latency test (MSLT) and each nap in narcolepsy patients. The results showed that AI during wakefulness was significantly higher in narcolepsy patients compared to other hypersomnia patients. AI during REM sleep and wakefulness in naps with sudden onsets of REM sleep periods were lower in NT1 than in NT2. AI during wakefulness had a high diagnostic value in distinguishing patients with other hypersomnias, while AI during REM sleep and wakefulness in naps with SOREMP showed a poor ability to differentiate NT1 and NT2.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Kiran P. Maski, Alicia Colclasure, Elaina Little, Erin Steinhart, Thomas E. Scammell, William Navidi, Cecilia Diniz Behn
Summary: This study found that narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH) have distinct nocturnal sleep stability phenotypes compared to subjectively sleepy controls, with NT1 demonstrating clear nocturnal wake and sleep instability.
Review
Medicine, General & Internal
Lynn M. Trotti, Lorne A. Becker, Catherine Friederich Murray, Romy Hoque
Summary: Modafinil demonstrates efficacy in improving symptoms of idiopathic hypersomnia, with potential for adverse effects. Clarithromycin does not show significant effectiveness in treating idiopathic hypersomnia. Additional studies are needed to further explore treatment options for this condition.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Lynn Marie Trotti, Prabhjyot Saini, Bruce Crosson, Carolyn C. Meltzer, David B. Rye, Jonathon A. Nye
Summary: The study compared patterns of regional brain metabolism in patients with idiopathic hypersomnia (IH), narcolepsy (NT1), and non-sleepy controls. The results showed that NT1 and IH patients have somewhat overlapping but distinct regional metabolism patterns.
Article
Clinical Neurology
Johannes Mathis, Daniel Andres, Wolfgang J. Schmitt, Claudio L. Bassetti, Christian W. Hess, David R. Schreier
Summary: This study explored the diagnostic value of selected sleep and vigilance tests beyond the multiple sleep latency test in differentiating between central disorders of hypersomnolence and fatigue syndromes. The results showed that SVT parameters had a high sensitivity and specificity in distinguishing between clinically suspected diagnoses. Although it was not possible to establish an overall prediction model based on SVTs alone, a combination of careful clinical assessment and SVTs improved the differentiation of central disorders of hypersomnolence.
Review
Cardiac & Cardiovascular Systems
Raoua Ben Messaoud, Charles Khouri, Jean Louis Pepin, Jean Luc Cracowski, Renaud Tamisier, Fabian Barbieri, Anna Heidbreder, Marie Joyeux-Faure, Pascal Defaye
Summary: This study evaluated the performance of implantable cardiac devices for sleep apnoea diagnosis and found that they have a clinically relevant respiratory disturbance index, which may improve access to sleep apnoea diagnosis in at-risk cardiovascular populations.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Matteo Cesari, Anna Heidbreder, Erik K. St Louis, Friederike Sixel-Doring, Donald L. Bliwise, Luca Baldelli, Frederik Bes, Maria Livia Fantini, Alex Iranzo, Stine Knudsen-Heier, Geert Mayer, Stuart McCarter, Jiri Nepozitek, Milena Pavlova, Federica Provini, Joan Santamaria, Jun-Sang Sunwoo, Aleksandar Videnovic, Birgit Hogl, Poul Jennum, Julie A. E. Christensen, Ambra Stefani
Summary: Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM) sleep behavior disorder (RBD). This study addresses the need for comprehensive and unambiguous v-PSG recommendations to diagnose RBD and identify prodromal RBD, aiming to provide objective v-PSG measures and enable future harmonized multicentric studies and clinical trials.
Article
Neurosciences
Yuri L. Sosero, Eric Yu, Mehrdad A. Estiar, Lynne Krohn, Kheireddin Mufti, Uladzislau Rudakou, Jennifer A. Ruskey, Farnaz Asayesh, Sandra B. Laurent, Dan Spiegelman, Jean-Francois Trempe, Timothy G. Quinnell, Nicholas Oscroft, Isabelle Arnulf, Jacques Y. Montplaisir, Jean-Francois Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Karel Sonka, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Francesco Biscarini, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Doering, Valerie Cochen De Cock, Christelle Charley Monaca, Anna Heidbreder, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley F. Boeve, Ronald B. Postuma, Guy A. Rouleau, Abubaker Ibrahim, Ambra Stefani, Birgit Hogl, Michele T. M. Hu, Ziv Gan-Or
Summary: This study found that loss-of-function mutations in the PSAP gene were present in patients with iRBD, and the co-occurrence with GBA variants suggests a potential genetic interaction. These findings may have implications for understanding the prodromal stage of synucleinopathy and the development of Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2022)
Editorial Material
Clinical Neurology
Christine Strippel, Anna Heidbreder, Andreas Schulte-Mecklenbeck, Lisanne Korn, Tobias Warnecke, Nico Melzer, Heinz Wiendl, Matthias Pawlowski, Catharina C. Gross, Stjepana Kovac
Summary: This study compared the clinical, MRI, and CSF findings of patients with anti-IgLON5 with patients with progressive supranuclear palsy (PSP) and functional neurologic disorder. The results indicate that patients with anti-IgLON5 have inflammatory changes in routine CSF analysis, an increase in B-lymphocyte frequency, and the presence of plasma cells, suggesting the importance of inflammatory mechanisms in these cases.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Review
Clinical Neurology
Birgit Hoegl, Isabelle Arnulf, Melanie Bergmann, Matteo Cesari, Ziv Gan-Or, Anna Heidbreder, Alex Iranzo, Lynne Krohn, Pierre-Herve Luppi, Brit Mollenhauer, Federica Provini, Joan Santamaria, Claudia Trenkwalder, Aleksandar Videnovic, Ambra Stefani
Summary: This manuscript provides an overview of REM sleep behaviour disorder (RBD), focusing on the contributions from European researchers. It covers the history, pathophysiology, clinical aspects, diagnostic issues, and the implications of RBD diagnosis and biomarkers.
JOURNAL OF SLEEP RESEARCH
(2022)
Editorial Material
Clinical Neurology
Anna Heidbreder, Sylvia Kotterba
Review
Clinical Neurology
Anna Grossauer, Anna Hussl, Philipp Mahlknecht, Marina Peball, Anna Heidbreder, Florian Deisenhammer, Atbin Djamshidian, Klaus Seppi, Beatrice Heim
Summary: Anti-IgLON5 disease is an autoimmune encephalopathy characterized by sleep disturbances. It has a wide range of clinical symptoms, including movement disorders, bulbar dysfunction, autonomic disorders, and neurocognitive impairment. This study reports a case of an 87-year-old woman with isolated progressive hemichorea. A literature review identified multiple cases of anti-IgLON5 disease with chorea as an extrapyramidal movement disorder in their clinical phenotype. Screening for IgLON5 antibodies should be considered in patients with unexplained movement disorders, including isolated hemichorea.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Meeting Abstract
Clinical Neurology
A. Ibrahim, R. Ferri, M. Cesari, B. Frauscher, A. Heidbreder, M. Bergmann, B. Hoegl, A. Stefani
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
M. Bergmann, J. Wanschitz, A. Stefani, A. Heidbreder, M. Cesari, E. Brandauer, W. Loescher, B. Hoegl
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
M. Cesari, K. Egger, A. Stefani, M. Bergmann, A. Ibrahim, E. Brandauer, B. Hoegl, A. Heidbreder
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
M. Cesari, L. Ruzicka, B. Hoegl, A. Ibrahim, E. Holzknecht, M. Bergmann, E. Brandauer, A. Heidbreder, H. Garn, B. Kohn, A. Stefani
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
A. Grossauer, A. Hussl, P. Mahlknecht, A. Heidbreder, K. Seppi, B. Heim
MOVEMENT DISORDERS
(2022)
Meeting Abstract
Clinical Neurology
M. Cesari, A. Heidbreder, C. Gaig, M. Bergmann, E. Brandauer, A. Iranzo, E. Holzknecht, J. Santamaria, B. Hogl, A. Stefani
Meeting Abstract
Clinical Neurology
J. K. Gool, Z. Zhang, M. S. Oei, S. Mathias, Y. Dauvilliers, G. Mayer, G. Plazzi, R. del Rio-Villegas, J. Santamaria, K. Sonka, M. Partinen, S. Overeem, R. Peraita-Adrados, R. Heinzer, A. Martins da Silva, B. Hogl, A. Wierzbicka, A. Heidbreder, E. Feketeova, M. Manconi, J. Buskova, F. Canellas, C. L. Bassetti, L. Barateau, F. Pizza, M. H. Schmidt, R. Fronczek, R. Khatami, G. J. Lammers
Article
Neurosciences
Melanie Bergmann, Elisabeth Brandauer, Ambra Stefani, Anna Heidbreder, Iris Unterberger, Birgit Hoegl
Summary: The study investigated the reasons and benefits of dual diagnostic assessments using video-polysomnography (VPSG) and prolonged video-EEG-monitoring (pVEEG-M). The majority of cases involved the diagnosis or monitoring of different comorbid diseases, while in other cases, both modalities were useful to achieve a higher diagnostic accuracy or to refute differential diagnoses. The combination of VPSG and pVEEG-M complement each other, especially in cases of two different comorbid diseases, to rule out differential diagnoses or when a higher diagnostic certainty is sought.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2022)
