Article
Cardiac & Cardiovascular Systems
Joanna Fishbein, Kristie M. Coleman, Amarbir Bhullar, Nikhil Sharma, Stefanos Zafeiropoulos, Umair Ansari, Tia Bimal, Yan Liu, Stavros E. Mountantonakis
Summary: This study retrospectively analyzed COVID-19 patients and identified independent factors associated with in-hospital mortality, which were incorporated into a risk score for prediction.
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Article
Medicine, General & Internal
Anthony A. Della Rossa, Priyadarshini M. Dixit, Ruchit Shah, Stephanie Hang, Jacky Duong
Summary: Propionic acidemia (PA) is a metabolic disorder associated with QT prolongation. This case describes a patient with known PA who experienced cardiac arrest and was subsequently implanted with an AICD.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Irene Hiniesto-Inigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjo, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin
Summary: In this study, the researchers investigated the potential modulation of the cardiac voltage-gated potassium channel KV7.1/KCNE1 by endocannabinoids. They found that certain endocannabinoids facilitate channel activation and have protective effects in Long QT Syndrome.
Article
Medicine, Research & Experimental
Britt Drogemoller, Galen E. B. Wright, Jessica Trueman, Kaitlyn Shaw, Michelle Staub, Shahnaz Chaudhry, Fudan Miao, Michelle Higginson, Gabriella S. S. Groeneweg, James Brown, Laura A. Magee, Simon D. Whyte, Nicholas West, Sonia M. Brodie, Geert 't Jong, Sara Israels, Howard Berger, Shinya Ito, Shahrad R. Rassekh, Shubhayan Sanatani, Colin J. D. Ross, Bruce C. Carleton
Summary: This study provides insights into the genomic basis of ondansetron-induced cardiac changes and highlights the importance of genes implicated in serotonin-related traits. These findings are biologically relevant and represent the first step towards improving the safety of this commonly used antiemetic medication.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Peiwen Li, Xiaohui Tian, Gongxin Wang, Enshe Jiang, Yanming Li, Guoliang Hao
Summary: In this study, it was found that osimertinib can cause prolongation of the QT interval, increased conduction time, and inhibition of channels. These findings might be the main cause of the cardiotoxicity effects induced by the drug.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Geoffrey A. Rubin, Amar D. Desai, Zilan Chai, Aijin Wang, Qixuan Chen, Amy S. Wang, Cameron Kemal, Haajra Baksh, Angelo Biviano, Jose M. Dizon, Hirad Yarmohammadi, Frederick Ehlert, Deepak Saluja, David A. Rubin, John P. Morrow, Uma Mahesh R. Avula, Jeremy P. Berman, Alexander Kushnir, Mark P. Abrams, Jessica A. Hennessey, Pierre Elias, Timothy J. Poterucha, Nir Uriel, Christine J. Kubin, Elijah LaSota, Jason Zucker, Magdalena E. Sobieszczyk, Allan Schwartz, Hasan Garan, Marc P. Waase, Elaine Y. Wan
Summary: In this study, COVID-19 infection was independently associated with significant mean QTc prolongation compared to patients without COVID-19, regardless of other clinical factors. More patients with COVID-19 had QTc of 500 milliseconds or greater compared to those without COVID-19.
Article
Cardiac & Cardiovascular Systems
Domenico Cozzolino, Ciro Romano, Riccardo Nevola, Aldo Marrone, Giuseppina R. Umano, Giovanna Cuomo, Luca Rinaldi, Luigi E. Adinolfi
Summary: This study evaluated the association of non-cardiac and cardiac comorbidities with arrhythmias and their impact on outcomes in hospitalized patients with COVID-19. The results showed that patients with arrhythmias were older, had more comorbidities, and had higher levels of inflammatory markers, electrocardiographic parameters, and biochemical markers. Age, coronary artery disease, and circulating troponin were identified as independent risk factors associated with arrhythmias. Patients with arrhythmias had a higher risk of in-hospital mortality. Therefore, the routine use of cardiac telemetry should be encouraged in COVID-19 wards.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
A. Bernjak, P. Novodvorsky, E. Chow, A. Iqbal, L. Sellors, S. Williams, R. A. Fawdry, J. L. B. Marques, R. M. Jacques, M. J. Campbell, P. J. Sheridan, S. R. Heller
Summary: This study examined the effect of spontaneous hyperglycaemia on heart rate variability, cardiac repolarisation, and cardiac arrhythmias in adults with type 1 diabetes mellitus without a history of cardiovascular disease. The results showed that hyperglycaemia was not associated with clinically important cardiac arrhythmias in these individuals.
DIABETES & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Akiko Kojima, Xinya Mi, Yutaka Fukushima, Wei-Guang Ding, Mariko Omatsu-Kanbe, Hiroshi Matsuura
Summary: This study revealed that the KCNE1 polymorphism D85N significantly increases the sensitivity of I-Ks to inhibition by propofol, suggesting a potential genetic susceptibility to propofol-induced QT prolongation in individuals carrying this variant.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Chien-Hsien Lo, Yu-Hsun Wang, Chin-Feng Tsai, Kuei-Chuan Chan, Li-Ching Li, Tse-Hsien Lo, James Cheng-Chung Wei, Chun-Hung Su
Summary: In patients with systemic lupus erythematosus, hydroxychloroquine treatment did not significantly increase the risk of cardiac arrhythmia or life-threatening ventricular arrhythmia regardless of the different hydroxychloroquine treatment duration, drug adherence rate, or daily dose.
Article
Pharmacology & Pharmacy
Kotaro Hori, Shogo Tsujikawa, Mika Egami, Sayaka Waki, Ryota Watanabe, Hideki Hino, Tadashi Matsuura, Takashi Mori
Summary: Thoracic epidural analgesia can prolong QT interval after general anesthesia, possibly due to the blockade of neighboring or part of the cardiac sympathetic nerves, rather than systemic effects of epidurally administered levobupivacaine.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Emergency Medicine
Lauren B. Robison, William J. Brady, Robert A. Robison, Nathan Charlton
Summary: Prolongation of the QTc interval is associated with an increased risk of malignant ventricular dysrhythmias and sudden cardiac death. However, specific quantifiable risk rates in relation to specific QTc interval length remain unknown. Current literature is inadequate to provide a definitive answer, requiring further prospective research on this topic.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Francesco Luzza, Rosalba De Sarro, Roberto Licordari, Pasquale Crea, Pietro Pugliatti, Giuseppe Certo, Lorenzo Pistelli, Francesca Campanella, Maria Claudia Lo Nigro, Matteo Casale, Michele Correale, Giuseppe Dattilo
Summary: QT interval varies with heart rate and needs to be corrected. Atrial fibrillation (AF) is associated with elevated heart rate and beat-to-beat variation. The study aims to find the best correlation between QTc in AF and restored sinus rhythm (SR) and determine the best correction formula and method for determining QTc in AF. The results show that Bazzett's formula is the least accurate in estimating QTc during AF.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Fariba Ahmadizar, Negin Soroush, M. Arfan Ikram, Jan A. Kors, Maryam Kavousi, Bruno H. Stricker
Summary: This study aimed to investigate the effects of hydroxychloroquine and chloroquine on electrocardiographic measures and sudden cardiac death. The results showed that current use of these drugs was associated with an increased QTc-interval duration and a higher risk of sudden cardiac death. Therefore, cardiotoxicity is a strong argument against using these drugs to treat COVID-19 infections, in addition to the controversial efficacy against the virus.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sean M. Kivlehan, Kathryne Tenney, Sam Plasmati, Vincenzo Bollettino, Katie Farineau, Eric J. Nilles, Greg Gottlieb, Stephanie R. Kayden
Summary: There is a continuous need for humanitarian training and professionalization. The COVID-19 pandemic disrupted in-person training programs, but a virtual humanitarian training simulation proved to be a feasible alternative. The virtual format preserved learning objectives, received positive feedback from participants, and was more affordable than traditional simulations.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Multidisciplinary Sciences
Alasdair D. Henderson, Mike Kama, Maite Aubry, Stephane Hue, Anita Teissier, Taina Naivalu, Vinaisi D. Bechu, Jimaima Kailawadoko, Isireli Rabukawaqa, Aalisha Sahukhan, Martin L. Hibberd, Eric J. Nilles, Sebastian Funk, Jimmy Whitworth, Conall H. Watson, Colleen L. Lau, W. John Edmunds, Van-Mai Cao-Lormeau, Adam J. Kucharski
Summary: After experiencing multiple dengue epidemics, Fiji showed evidence of multi-year Zika virus transmission between 2013 and 2017, likely influenced by seasonal effects and timing of introduction. This study highlights contrasting transmission dynamics of closely related flaviviruses in the same populations, emphasizing the importance of considering multiple factors in outbreak modeling.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Angela Cadavid Restrepo, Luis Furuya-Kanamori, Helen Mayfield, Eric Nilles, Colleen L. Lau
Summary: Globalization has led to increased international travel, facilitating the rapid spread of emerging pathogens with epidemic potential. This study analyzed travel data and the Infectious Disease Vulnerability Index to assess travel networks and disease transmission risk in Oceania. The results showed high connectivity between Oceania and countries in Asia, Europe, and North America, with variability in the geographical distribution of international connections among Pacific Island Countries and Territories.
Article
Immunology
Paulina Kaplonek, Stephanie Fischinger, Deniz Cizmeci, Yannic C. Bartsch, Jaewon Kang, John S. Burke, Sally A. Shin, Diana Dayal, Patrick Martin, Colin Mann, Fatima Amanat, Boris Julg, Eric J. Nilles, Elon R. Musk, Anil S. Menon, Florian Krammer, Erica Ollman Saphire, Andrea Carfi, Galit Alter
Summary: SARS-CoV-2 mRNA vaccines provide protection against COVID-19, but concerns have arisen due to the emergence of variants that may reduce the efficacy of existing vaccines. This study investigated the binding and functional capacity of antibodies from recovered individuals and those induced by the Moderna mRNA1273 COVID-19 vaccine against SARS-CoV-2 variants of concern. While neutralizing responses to the variants decreased in both groups, the Fc-mediated responses differed. Antibodies from recovered individuals showed compromised interactions with Fc receptors, while vaccine-induced antibodies maintained their ability to interact with Fc receptors and mediate antibody effector functions. These findings suggest that mRNA vaccines may offer resilience in the humoral immune response and continue to provide protection against SARS-CoV-2 variants independent of neutralization.
Article
Microbiology
Sameed M. Siddiqui, Kathryn A. Bowman, Alex L. Zhu, Stephanie Fischinger, Samuel Beger, Jenny S. Maron, Yannic C. Bartsch, Caroline Atyeo, Matthew J. Gorman, Ahmad Yanis, Judd F. Hultquist, Ramon Lorenzo-Redondo, Egon A. Ozer, Lacy M. Simons, Rana Talj, Danielle A. Rankin, Lindsay Chapman, Kyle Meade, Jordan Steinhart, Sean Mullane, Suzanne Siebert, Hendrik Streeck, Pardis Sabeti, Natasha Halasa, Elon R. Musk, Dan H. Barouch, Anil S. Menon, Eric J. Nilles, Douglas A. Lauffenburger, Galit Alter
Summary: As public health guidelines have relaxed, SARS-CoV-2 is likely to remain endemic due to the rise of more infectious variants. Reexposure and reinfection cases have been observed globally, highlighting the need for detecting and monitoring reinfection to prevent vaccine escape mutations. This study identifies simple immune biomarkers of reinfection in rhesus macaques and demonstrates their potential utility in human reinfection cases, providing a cost-effective and scalable marker for targeted pandemic response.
Article
Biochemistry & Molecular Biology
Emilie Finch, Rachel Lowe, Stephanie Fischinger, Michael De St Aubin, Sameed M. Siddiqui, Diana Dayal, Michael A. Loesche, Justin Rhee, Samuel Beger, Yiyuan Hu, Matthew J. Gluck, Benjamin Mormann, Mohammad A. Hasdianda, Elon R. Musk, Galit Alter, Anil S. Menon, Eric J. Nillesid, Adam J. Kucharski
Summary: This study analysed longitudinal PCR and serological testing data from a cohort of US employees and found that primary infection with SARS-CoV-2 provides protection against reinfection in the majority of individuals for at least 6 months.
Article
Medicine, General & Internal
Phuong N. Pham, Manasi Sharma, Kennedy Kihangi Bindu, Pacifique Zikomangane, Rachel C. Nethery, Eric Nilles, Patrick Vinck
Summary: This study found gender differences in adopting preventive protective behaviors against EVD. These findings suggest that it is critical to design gender-sensitive communication and vaccination strategies, while engaging women and their community as a whole in any response to infectious disease outbreaks. Research on the potential link between gender and sociodemographics factors associated with disease risk and outcomes is needed.
Article
Cell Biology
Paulina Kaplonek, Deniz Cizmeci, Stephanie Fischinger, Ai-Ris Collier, Todd Suscovich, Caitlyn Linde, Thomas Broge, Colin Mann, Fatima Amanat, Diana Dayal, Justin Rhee, Michael de St Aubin, Eric J. Nilles, Elon R. Musk, Anil S. Menon, Erica Ollmann Saphire, Florian Krammer, Douglas A. Lauffenburger, Dan H. Barouch, Galit Alter
Summary: The successful development of COVID-19 vaccines has led to reduced morbidity and mortality. However, the emergence of viral variants has affected the efficacy of the vaccines, showing differences between two approved mRNA platforms, BNT162b2 and mRNA-1273. Understanding the differences in immune responses induced by these vaccines is important for determining their protective immunity.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Letter
Infectious Diseases
Eric J. Nilles, Cecilia Then Paulino, Michael de St Aubin, William Duke, Petr Jarolim, Isaac Miguel Sanchez, Kristy O. Murray, Colleen L. Lau, Emily Zielinski Gutierrez, Ronald Skewes Ramm, Marietta Vasquez, Adam Kucharski
LANCET INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Beatris Mario Martin, Angela Cadavid Restrepo, Helen J. Mayfield, Cecilia Then Paulino, Micheal De St Aubin, William Duke, Petr Jarolim, Emily Zielinski Gutierrez, Ronald Skewes Ramm, Devan Dumas, Salome Garnier, Marie Caroline Etienne, Farah Pena, Gabriela Abdalla, Beatriz Lopez, Lucia de la Cruz, Bernarda Henriquez, Margaret Baldwin, Benn Sartorius, Adam Kucharski, Eric James Nilles, Colleen L. Lau
Summary: This study investigated the variation in seroprevalence of SARS-CoV-2 at sub-national levels in the Dominican Republic and identified factors influencing this variation. The findings showed that receiving two doses of the COVID-19 vaccine was associated with significantly higher odds of seropositivity, indicating the importance of vaccination in increasing population immunity. These results can inform regional-level public health responses and strategies for increasing vaccination coverage.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Eric J. Nilles, Michael de St Aubin, Devan Dumas, William Duke, Marie Caroline Etienne, Gabriela Abdalla, Petr Jarolim, Timothy Oasan, Salome Garnier, Naomi Iihoshi, Beatriz Lopez, Lucia de la Cruz, Yosanly Cornelio Puello, Margaret Baldwin, Kathryn W. Roberts, Farah Pena, Kara Durski, Isaac Miguel Sanchez, Sarah M. Gunter, Alexander R. Kneubehl, Kristy O. Murray, Allison Lino, Sarah Strobel, Amado Alejandro Baez, Colleen L. Lau, Adam Kucharski, Emily Zielinski Gutierrez, Ronald Skewes-Ramm, Marietta Vasquez, Cecilia Then Paulino
Summary: To assess the changes in SARS-CoV-2 spike binding antibody prevalence and its implications for immunologic protection against variants of concern, a prospective study was conducted in the Dominican Republic from March 2021 to August 2022, involving 2,300 patients with undifferentiated febrile illnesses. Serum samples were tested for spike antibodies and nasopharyngeal samples were tested for acute SARS-CoV-2 infection. The study found that geometric mean spike antibody titers significantly increased over time, and higher antibody levels were associated with reduced odds of acute infection, regardless of the viral strain. The combination of serologic and virologic screening could help monitor population immunologic markers and their impact on emerging variant transmission.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Biochemical Research Methods
Hong Yue, Radoslaw P. Nowak, Daan Overwijn, N. Connor Payne, Stephanie Fischinger, Caroline Atyeo, Evan C. Lam, Kerri St. Denis, Lauren K. Brais, Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Lindsey R. Baden, Eric J. Nilles, Elizabeth W. Karlson, Xu G. Yu, Jonathan Z. Li, Ann E. Woolley, Irene M. Ghobrial, Jeffrey A. Meyerhardt, Alejandro B. Balazs, Gali Alter, Ralph Mazitschek, Eric S. Fischer
Summary: Serological assays play an important role in diagnosing and monitoring infectious diseases. However, current methods have limitations in terms of technology and sample types. In this study, we developed a new serological assay based on TR-FRET technology, which showed exceptional versatility, scalability, and sensitivity. It outperformed or matched existing strategies in terms of sensitivity, specificity, and precision. This assay was successfully applied to measure antibody levels against different viruses and can be extended to other antigens.
CELL REPORTS METHODS
(2023)
Article
Immunology
Michael Loesche, Elizabeth W. Karlson, Opeyemi Talabi, Guohai Zhou, Natalie Boutin, Rachel Atchley, Gideon Loevinsohn, Jun Bai Park Chang, Mohammad A. Hasdianda, Adetoun Okenla, Elizabeth Sampson, Haley Schram, Karen Magsipoc, Kirsten Goodman, Lauren Donahue, Maureen MacGowan, Lewis A. Novack, Petr Jarolim, Lindsey R. Baden, Eric J. Nilles
Summary: The substantial seroreversion of nucleocapsid total immunoglobulin found in this study emphasizes the need to account for seroreversion in seroepidemiologic studies.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Eric J. Nilles, Cecilia Then Paulino, Michael De St Aubin, Angela Cadavid Restrepo, Helen Mayfield, Devan Dumas, Emilie Finch, Salome Garnier, Marie Caroline Etienne, Louisa Iselin, William Duke, Petr Jarolim, Timothy Oasan, Jingyou Yu, Huahua Wan, Farah Pena, Naomi Iihoshi, Gabriela Abdalla, Beatriz Lopez, Lucia de la Cruz, Bernarda Henriquez, Andres Espinosa-Bode, Yosanly Cornelio Puello, Kara Durski, Margaret Baldwin, Amado Alejandro Baez, Roland C. Merchant, Dan H. Barouch, Ronald Skewes-Ramm, Emily Zielinski Gutierrez, Adam Kucharski, Colleen L. Lau
Summary: This study investigated SARS-CoV-2 infection and immunological protection in the Dominican Republic, revealing a high prevalence of cumulative infections and variations in immune protection among different subgroups. These findings are important for guiding public health interventions.
LANCET REGIONAL HEALTH-AMERICAS
(2022)
Article
Microbiology
Sameed M. Siddiqui, Kathryn A. Bowman, Alex L. Zhu, Stephanie Fischinger, Samuel Beger, Jenny S. Maron, Yannic C. Bartsch, Caroline Atyeo, Matthew J. Gorman, Ahmad Yanis, Judd F. Hultquist, Ramon Lorenzo-Redondo, Egon A. Ozer, Lacy M. Simons, Rana Talj, Danielle A. Rankin, Lindsay Chapman, Kyle Meade, Jordan Steinhart, Sean Mullane, Suzanne Siebert, Hendrik Streeck, Pardis Sabeti, Natasha Halasa, Elon R. Musk, Dan H. Barouch, Anil S. Menon, Eric J. Nilles, Douglas A. Lauffenburger, Galit Alter
Summary: This study emphasizes the importance of detecting SARS-CoV-2 reinfection and suggests that simple antibody titers and function can serve as markers of reinfection, providing increased resolution and resilience against new outbreaks.
