Chaperonin 60: a paradoxical, evolutionarily conserved protein family with multiple moonlighting functions

Mycobacterium tuberculosisChaperonin 60.1 Inhibits Leukocyte Diapedesis in a Murine Model of Allergic Lung Inflammation

(2012) Yanira Riffo-Vasquez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

(2012) Krishanu Mukherjee et al.   BMC EVOLUTIONARY BIOLOGY

An Insecticidal Protein from Xenorhabdus ehlersii Triggers Prophenoloxidase Activation and Hemocyte Decrease in Galleria mellonella

(2012) Huaixing Shi et al.   CURRENT MICROBIOLOGY

Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance

(2012) T. Marker et al.   DIABETES

HSP60 is transported through the secretory pathway of 3-MCA-induced fibrosarcoma tumour cells and undergoes N-glycosylation

(2012) Dana Hayoun et al.   FEBS Journal

An insecticidal protein from Xenorhabdus budapestensis that results in prophenoloxidase activation in the wax moth, Galleria mellonella

(2012) Jun Yang et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

The unusual mycobacterial chaperonins: evidence forin vivooligomerization and specialization of function

(2012) MingQi Fan et al.   MOLECULAR MICROBIOLOGY

Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity

(2012) Dongmei Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis

(2011) A. Ronaghy et al.   ANNALS OF THE RHEUMATIC DISEASES

Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide

(2011) E. Zonneveld-Huijssoon et al.   ANNALS OF THE RHEUMATIC DISEASES

On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: Biochemical mechanisms and regulatory control

(2011) Michael A. Sirover   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial-Mesenchymal Transition Regulated by miR-200 in Breast Cancer Cells

(2011) A. Ahmad et al.   CANCER RESEARCH

Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release

(2011) M Fu et al.   CELL DEATH AND DIFFERENTIATION

Antibodies against Helicobacter pylori heat shock protein 60 aggravate HSP60-mediated proinflammatory responses

(2011) Kuang-Wen Liao et al.   CYTOKINE

Surface-associated Hsp60 chaperonin of Leptospira interrogans serovar Autumnalis N2 strain as an immunoreactive protein

(2011) K. Natarajaseenivasan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

1,25-Dihydroxyvitamin D3 enhances NK susceptibility of human melanoma cells via Hsp60-mediated FAS expression

(2011) Ji H. Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DiaPep277 peptide therapy in the context of other immune intervention trials in type 1 diabetes

(2011) Dario Tuccinardi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Bacterial Virulence in the Moonlight: Multitasking Bacterial Moonlighting Proteins Are Virulence Determinants in Infectious Disease

(2011) Brian Henderson et al.   INFECTION AND IMMUNITY

Human heat-shock protein 60 receptor-coated paramagnetic beads show improved capture of Listeria monocytogenes in the presence of other Listeria in food

(2011) O.K. Koo et al.   JOURNAL OF APPLIED MICROBIOLOGY

Myocardial Ischemia Activates an Injurious Innate Immune Signaling via Cardiac Heat Shock Protein 60 and Toll-like Receptor 4

(2011) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class B Scavenger Receptor Types I and II and CD36 Mediate Bacterial Recognition and Proinflammatory Signaling Induced by Escherichia coli, Lipopolysaccharide, and Cytosolic Chaperonin 60

(2011) I. N. Baranova et al.   JOURNAL OF IMMUNOLOGY

GroEL1, a Heat Shock Protein 60 of Chlamydia pneumoniae , Induces Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Expression in Endothelial Cells and Enhances Atherogenesis in Hypercholesterolemic Rabbits

(2011) Feng-Yen Lin et al.   JOURNAL OF IMMUNOLOGY

Bacterial Heat Shock Protein 60, GroEL, Can Induce the Conversion of Naïve T Cells into a CD4+ CD25+ Foxp3-Expressing Phenotype

(2011) Ryuji Ohue et al.   Journal of Innate Immunity

Dynamics of heat shock protein 60 in endothelial cells exposed to cigarette smoke extract

(2011) Simone Barbara Kreutmayer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Dimeric Structure of the Cpn60.2 Chaperonin of Mycobacterium tuberculosis at 2.8 Å Reveals Possible Modes of Function

(2011) Anat Shahar et al.   JOURNAL OF MOLECULAR BIOLOGY

Heat shock protein 60 from Klebsiella pneumoniae protects mononuclear cells from apoptotic cell death induced by dexamethasone

(2011) Yolanda Ortega-Ortega et al.   MICROBIAL PATHOGENESIS

Fusobacterium nucleatum GroEL induces risk factors of atherosclerosis in human microvascular endothelial cells and ApoE−/− mice

(2011) H-R. Lee et al.   Molecular Oral Microbiology

Advances in osteoclast biology: old findings and new insights from mouse models

(2011) James R. Edwards et al.   Nature Reviews Rheumatology

Mitochondrial heat shock protein participates in placental steroidogenesis

(2011) S. Olvera-Sanchez et al.   PLACENTA

Histoplasma capsulatum Heat-Shock 60 Orchestrates the Adaptation of the Fungus to Temperature Stress

(2011) Allan Jefferson Guimarães et al.   PLoS One

Autoantibodies to Endothelial Cell Surface ATP Synthase, the Endogenous Receptor for Hsp60, Might Play a Pathogenic Role in Vasculatides

(2011) Jean-Eric Alard et al.   PLoS One

N-Terminal Gly224–Gly411 Domain in Listeria Adhesion Protein Interacts with Host Receptor Hsp60

(2011) Balamurugan Jagadeesan et al.   PLoS One

Antimicrobial Peptides Keep Insect Endosymbionts Under Control

(2011) F. H. Login et al.   SCIENCE

The tumour-suppressive function of CLU is explained by its localisation and interaction with HSP60

(2011) K-A Chaiwatanasirikul et al.   Cell Death & Disease

A Chaperonin Subunit with Unique Structures Is Essential for Folding of a Specific Substrate

(2011) Lianwei Peng et al.   PLOS BIOLOGY

Loss and gain of GroEL in the MollicutesThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Gregory W. Clark et al.   Biochemistry and Cell Biology

A more precise characterization of chaperonin substrates

(2010) Emanuele Raineri et al.   BIOINFORMATICS

Comparative Biochemical Characterization of Two GroEL Homologs from the CyanobacteriumSynechococcus elongatusPCC 7942

(2010) Saaimatul HUQ et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells

(2010) J. C. Ghosh et al.   CANCER RESEARCH

Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice

(2010) Jane H. Christensen et al.   CELL STRESS & CHAPERONES

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis

(2010) Yaw Chong Goh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface

(2010) Tyler B. M. Hickey et al.   CELLULAR MICROBIOLOGY

Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells

(2010) J. S. FRIEDLAND et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A systematic survey of in vivo obligate chaperonin-dependent substrates

(2010) Kei Fujiwara et al.   EMBO JOURNAL

Agglutination ofHistoplasma capsulatumby IgG Monoclonal Antibodies against Hsp60 Impacts Macrophage Effector Functions

(2010) Allan Jefferson Guimarães et al.   INFECTION AND IMMUNITY

GroEL and Lipopolysaccharide from Francisella tularensis Live Vaccine Strain Synergistically Activate Human Macrophages

(2010) C. E. Noah et al.   INFECTION AND IMMUNITY

Listeria monocytogenes Uses Listeria Adhesion Protein (LAP) To Promote Bacterial Transepithelial Translocation and Induces Expression of LAP Receptor Hsp60

(2010) K. M. Burkholder et al.   INFECTION AND IMMUNITY

Comparison of the Moonlighting Actions of the Two Highly Homologous Chaperonin 60 Proteins of Mycobacterium tuberculosis

(2010) A. Cehovin et al.   INFECTION AND IMMUNITY

Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells

(2010) Rajneesh Jha et al.   INFLAMMATION RESEARCH

Myxococcus xanthus Viability Depends on GroEL Supplied by Either of Two Genes, but the Paralogs Have Different Functions during Heat Shock, Predation, and Development

(2010) J. Li et al.   JOURNAL OF BACTERIOLOGY

Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation

(2010) Brian Henderson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Usefulness of the hsp60 gene for the identification and classification of Gram-negative anaerobic rods

(2010) M. Sakamoto et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Transmission Efficiency of Tomato Yellow Leaf Curl Virus by the Whitefly Bemisia tabaci Is Correlated with the Presence of a Specific Symbiotic Bacterium Species

(2010) Y. Gottlieb et al.   JOURNAL OF VIROLOGY

LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species

(2010) B. Jagadeesan et al.   MICROBIOLOGY-SGM

Biochemical and immunological characterization of a cpn60.1 knockout mutant of Mycobacterium bovis BCG

(2010) X.-M. Wang et al.   MICROBIOLOGY-SGM

Cytosolic Hsp60 Is Involved in the NF-κB-Dependent Survival of Cancer Cells via IKK Regulation

(2010) Jung Nyeo Chun et al.   PLoS One

Archaeal-like chaperonins in bacteria

(2010) S. M. Techtmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule spectroscopy of protein folding in a chaperonin cage

(2010) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation among HSP60 sequences in relation to structure, function, and evolution

(2010) Luciano Brocchieri et al.   PROTEIN SCIENCE

Multiple moonlighting functions of mycobacterial molecular chaperones

(2010) Brian Henderson et al.   TUBERCULOSIS

Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer

(2010) Mitsushige Sugimoto   WORLD JOURNAL OF GASTROENTEROLOGY

Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG

(2010) Maria V. Carroll et al.   Protein & Cell

Lactic acid bacteria display on the cell surface cytosolic proteins that recognize yeast mannan

(2009) Yoshio Katakura et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Expressing a whitefly GroEL protein in Nicotiana benthamiana plants confers tolerance to tomato yellow leaf curl virus and cucumber mosaic virus, but not to grapevine virus A or tobacco mosaic virus

(2009) Dagan Edelbaum et al.   ARCHIVES OF VIROLOGY

Characterizing the polymeric status of Helicobacter pylori heat shock protein 60

(2009) Ching-Yi Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heat shock protein 60 and adipocytes: Characterization of a ligand-receptor interaction

(2009) Tina Märker et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plastid chaperonin proteins Cpn60α and Cpn60β are required for plastid division in Arabidopsis thaliana

(2009) Kenji Suzuki et al.   BMC PLANT BIOLOGY

Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors

(2009) Yang Soon Kim et al.   BONE

Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency

(2009) Jung-Min Koh et al.   BONE

Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-α-mediated apoptosis

(2009) Su-Min Kang et al.   CANCER LETTERS

Interaction between HSP60 and β-catenin promotes metastasis

(2009) Ya-Ping Tsai et al.   CARCINOGENESIS

Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells

(2009) C. Chen et al.   CARDIOVASCULAR RESEARCH

Reconciling theories of chaperonin accelerated folding with experimental evidence

(2009) Andrew I. Jewett et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular Heat Shock Protein 60, Cardiac Myocytes, and Apoptosis

(2009) Se-Chan Kim et al.   CIRCULATION RESEARCH

Extraordinarily widespread and fantastically complex: comparative biology of endosymbiotic bacterial and fungal mutualists of insects

(2009) Cara M. Gibson et al.   ECOLOGY LETTERS

Heat shock protein 60: Evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation

(2009) Elke Gülden et al.   FEBS LETTERS

The GroEL/GroES cis cavity as a passive anti-aggregation device

(2009) Arthur L. Horwich et al.   FEBS LETTERS

The Purified and Recombinant Legionella pneumophila Chaperonin Alters Mitochondrial Trafficking and Microfilament Organization

(2009) A. Chong et al.   INFECTION AND IMMUNITY

Chlamydial Heat Shock Protein 60 Induces Acute Pulmonary Inflammation in Mice via the Toll-Like Receptor 4- and MyD88-Dependent Pathway

(2009) Y. Bulut et al.   INFECTION AND IMMUNITY

Monoclonal Antibodies to Heat Shock Protein 60 Alter the Pathogenesis of Histoplasma capsulatum

(2009) A. J. Guimaraes et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Cpn60.2 and DnaK Are Located on the Bacterial Surface, Where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages

(2009) T. B. M. Hickey et al.   INFECTION AND IMMUNITY

Heat Shock Protein 60, via MyD88 Innate Signaling, Protects B Cells from Apoptosis, Spontaneous and Induced

(2009) M. Cohen-Sfady et al.   JOURNAL OF IMMUNOLOGY

Heat shock protein 60 (HSP60) stimulates neutrophil effector functions

(2009) Anke Osterloh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lactobacillus plantarum 299v Surface-Bound GAPDH: A New Insight Into Enzyme Cell Walls Location

(2009) N. Saad   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase

(2009) Maria Fairbank et al.   Molecular BioSystems

Moonlighting proteins—an update

(2009) Constance J. Jeffery   Molecular BioSystems

Differential substrate specificity of group I and group II chaperonins in the archaeonMethanosarcina mazei

(2009) Angela M. Hirtreiter et al.   MOLECULAR MICROBIOLOGY

A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL

(2009) Debashree Basu et al.   NUCLEIC ACIDS RESEARCH

Two chaperonin systems in bacterial genomes with distinct ecological roles

(2009) Tom A. Williams et al.   TRENDS IN GENETICS

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

(2008) Daniella Magen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells

(2008) Jie Qiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identification of the Molecular Chaperone, Heat Shock Protein 1 (Chaperonin 10), in the Reproductive Tract and in Capacitating Spermatozoa in the Male Mouse1

(2008) Andrew Walsh et al.   BIOLOGY OF REPRODUCTION

Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance

(2008) Jean Pieters   Cell Host & Microbe

Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster

(2008) Richa Arya et al.   CELL STRESS & CHAPERONES

In vivo imaging of the effect of LPS on arterial endothelial cells: molecular imaging of heat shock protein 60 expression

(2008) Marius C. Wick et al.   CELL STRESS & CHAPERONES

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The two homologous chaperonin 60 proteins ofMycobacterium tuberculosishave distinct effects on monocyte differentiation into osteoclasts

(2008) Vivienne R. Winrow et al.   CELLULAR MICROBIOLOGY

Mycobacterium tuberculosisheat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages

(2008) Nooruddin Khan et al.   CELLULAR MICROBIOLOGY

Hsp60C is required in follicle as well as germline cells during oogenesis inDrosophila melanogaster

(2008) Surajit Sarkar et al.   DEVELOPMENTAL DYNAMICS

Heat shock protein 60 induces inflammatory mediators in mouse adipocytes

(2008) Elke Gülden et al.   FEBS LETTERS

Immunoproteomic assay of surface proteins ofStreptococcus suisserotype 9

(2008) Zongfu Wu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection

(2008) Y. Hu et al.   INFECTION AND IMMUNITY

Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12

(2008) A. Osterloh et al.   INTERNATIONAL IMMUNOLOGY

Taxonomic analysis of Sorangium strains based on HSP60 and 16S rRNA gene sequences and morphology

(2008) D.-M. Jiang et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Chlamydia pneumoniae GroEL1 Protein Is Cell Surface Associated and Required for Infection of HEp-2 Cells

(2008) F. N. Wuppermann et al.   JOURNAL OF BACTERIOLOGY

An Insecticidal GroEL Protein with Chitin Binding Activity fromXenorhabdus nematophila

(2008) Mohan Chandra Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Expression of Heat Shock Protein HSP60A Reveals a Dynamic Mitochondrial Pattern inDrosophila melanogasterEmbryos

(2008) Luis Alberto Baena-López et al.   JOURNAL OF PROTEOME RESEARCH

Identification of Bombyx mori 14-3-3 orthologs and the interactor Hsp60

(2008) Hiroko Tabunoki et al.   NEUROSCIENCE RESEARCH

Cpn20: Siamese twins of the chaperonin world

(2008) Celeste Weiss et al.   PLANT MOLECULAR BIOLOGY

Mycobacterium tuberculosis Rv2224c modulates innate immune responses

(2008) J. Rengarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA