ADARs: allies or enemies? The importance of A-to-I RNA editing in human disease: from cancer to HIV-1

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

A-to-I RNA editing and cancer: From pathology to basic science

(2011) Angela Gallo et al.   RNA Biology

TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2

(2010) Hitoshi Aizawa et al.   ACTA NEUROPATHOLOGICA

Neurobehavioral phenotype in Prader-Willi syndrome

(2010) Joyce Whittington et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

DARNED: a DAtabase of RNa EDiting in humans

(2010) A. Kiran et al.   BIOINFORMATICS

A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins

(2010) Mats Ensterö et al.   BMC BIOINFORMATICS

Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats

(2010) Shoshana Greenberger et al.   BMC GENOMICS

The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove

(2010) Richard Stefl et al.   CELL

Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis

(2010) Liu Yang et al.   FASEB JOURNAL

Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries

(2010) M. J.L. de Hoon et al.   GENOME RESEARCH

Human BLCAP transcript: new editing events in normal and cancerous tissues

(2010) Federica Galeano et al.   INTERNATIONAL JOURNAL OF CANCER

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2

(2010) T. Hideyama et al.   JOURNAL OF NEUROSCIENCE

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome

(2010) Michael V. Morabito et al.   NEUROBIOLOGY OF DISEASE

RNA processing pathways in amyotrophic lateral sclerosis

(2010) Marka van Blitterswijk et al.   NEUROGENETICS

Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

(2010) Johannes H. Schulte et al.   NUCLEIC ACIDS RESEARCH

A novel tissue-specific alternatively spliced form of the A-to-I RNA editing enzyme ADAR2

(2010) Lily Agranat et al.   RNA Biology

RNA editing and its impact on GABAAreceptor function

(2009) Chammiran Daniel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of 5′- and 3′-untranslated regions of mRNAs in human diseases

(2009) Sangeeta Chatterjee et al.   BIOLOGY OF THE CELL

Editing independent effects of ADARs on the miRNA/siRNA pathways

(2009) Bret S E Heale et al.   EMBO JOURNAL

A novel 1.4 Mb de novo microdeletion of chromosome 1q21.3 in a child with microcephaly, dysmorphic features and mental retardation

(2009) Sujana Reddy et al.   European Journal of Medical Genetics

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

(2009) H. Wahlstedt et al.   GENOME RESEARCH

Origins and evolution of ADAR-mediated RNA editing

(2009) Yongfeng Jin et al.   IUBMB LIFE

Interferons and autoimmune disorders

(2009) Olivier Meyer   JOINT BONE SPINE

ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication

(2009) G. Clerzius et al.   JOURNAL OF VIROLOGY

RNA-Regulated Interaction of Transportin-1 and Exportin-5 with the Double-Stranded RNA-Binding Domain Regulates Nucleocytoplasmic Shuttling of ADAR1

(2009) J. Fritz et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets

(2009) J. M. Flanagan et al.   MOLECULAR CANCER THERAPEUTICS

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE

Identification of a selective nuclear import signal in adenosine deaminases acting on RNA

(2009) Stefan Maas et al.   NUCLEIC ACIDS RESEARCH

Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection

(2009) Margherita Doria et al.   NUCLEIC ACIDS RESEARCH

Novel Exon of Mammalian ADAR2 Extends Open Reading Frame

(2009) Stefan Maas et al.   PLoS One

RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

(2009) Paola Sebastiani et al.   PLoS One

ADAR1 is required for hematopoietic progenitor cell survival via RNA editing

(2009) R. XuFeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons

(2008) Nicholas P. Whitney et al.   FASEB JOURNAL

Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes

(2008) Robert J. Orlowski et al.   IMMUNOLOGY

Down-regulation of RNA Editing in Pediatric Astrocytomas

(2008) Caterina Cenci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double-Stranded RNA Adenosine Deaminases Enhance Expression of Human Immunodeficiency Virus Type 1 Proteins

(2008) A. Phuphuakrat et al.   JOURNAL OF VIROLOGY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5′-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon

(2008) Cyril X. George et al.   VIROLOGY