Journal
BIOLOGICAL RESEARCH
Volume 46, Issue 1, Pages 27-32Publisher
SOC BIOLGIA CHILE
DOI: 10.4067/S0716-97602013000100004
Keywords
Astrocytes; corpus callosum; genu; glial cells; splenium
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Funding
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) [81911, 166964]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica de la Universidad Nacional Autonoma de Mexico (PAPIIT-UNAM) [IN204809, IB200412]
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Axons and glial cells are the main components of white matter. The corpus callosum (CC) is the largest white matter tract in mammals; in rodents, 99% of the cells correspond to glia after postnatal day 5 (P5). The area of the CC varies through life and regional differences related to the number of axons have been previously described. Whether glial cell density varies accordingly is unknown; thus the aim of this study was to estimate glial cell density for the genu, body and splenium -the three main regions of CC-, of P6 and P30 rats. Here we report that the density of CC glial cells reduced by similar to 10% from P6 to P30. Even so, the density of astrocytes showed a slight increase (+6%), probably due to differentiation of glioblasts. Interestingly, glial cell density decreased for the genu (-21%) and the body (-13%), while for the splenium a minor increase (+5%) was observed. The astrocyte/glia ratio increased (from P6 to P30) for the genu (+27%), body (+17%) and splenium (+4%). Together, our results showed regional differences in glial cell density of the CC. Whether this pattern is modified in some neuropathologies remains to be explored.
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