☆ 4.4 Article

Oxidative imbalance in adult attention deficit/hyperactivity disorder

BIOLOGICAL PSYCHOLOGY (2008)

Journal

BIOLOGICAL PSYCHOLOGY

Volume 79, Issue 2, Pages 256-259

Publisher

ELSEVIER SCIENCE BV

DOI: 10.1016/j.biopsycho.2008.06.005

Keywords

Adult attention deficit hyperactivity disorder; Nitric oxide; Superoxide dismutase; Oxidative stress

Categories

Psychology, Biological Behavioral Sciences Psychology Psychology, Experimental

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Abstract

Objective: There are few studies evaluating the biochemical basis of adult attention deficit/hyperactivity disorder (A-ADHD). In the present study, we evaluated whether nitric oxide (NO), an oxidant, level and superoxide dismutase (SOD), an antioxidant, activity are associated with A-ADHD or not. Methods: Twenty A-ADHD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinic, diagnosed according to The Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists (H.A.S. and S.S.), and twenty-one healthy volunteer controls were included. Blood samples were collected; NO levels and SOD activities were measured. Results: The mean NO levels in patients were significantly higher than those of controls and SOD activity of patients was significantly lower than controls. Conclusions: Remarkable high levels of oxidant NO, and low SOD activities suggest an oxidative imbalance in A-ADHD. This is the first study evaluating the oxidative metabolism in A-ADHD. (C) 2008 Elsevier B.V. All rights reserved.

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