Article
Biology
Marieke M. B. Hoekstra, Maxime Jan, Georgia Katsioudi, Yann Emmenegger, Paul Franken
Summary: The study demonstrated a correlation between PER2 bioluminescence and sleep-wake status in peripheral tissues, indicating integration of sleep-wake information by clock gene circuitry. Mathematical modeling revealed a dynamic description of PER2 driven by sleep-wake-dependent and SCN-independent circadian forces.
Article
Behavioral Sciences
John A. Groeger, June C-Y. Lo, Nayantara Santhi, Alpar S. Lazar, Derk-Jan Dijk
Summary: Laboratory-based studies have shown that sleep restriction or deprivation can lead to a decrease in positive affect, worsening mood, and an increase in hostility. Mood changes can also occur when individuals sleep during atypical circadian phases. These findings highlight the importance of sleep in regulating emotions and suggest that mood changes systematically as sleep is shortened or mistimed.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Francy Cruz-Sanabria, Ugo Faraguna, Miriam Violi, Simone Bruno, Davide Gravina, Chiara Bonelli, Andrea Bazzani, Leonardo Massoni, Laura Musetti, Marly Simoncini, Paolo Frumento, Liliana Dell 'Osso, Claudia Carmassi
Summary: The present study evaluates the effect of exogenous melatonin on sleep and circadian parameters in patients with bipolar disorder and delayed sleep-wake phase disorder. Results indicate that personalized treatment with exogenous melatonin can modify self-reported chronotype, sleep onset time, and sleep efficiency and duration in patients with comorbid bipolar disorder and delayed sleep-wake phase disorder, suggesting potential efficacy in improving sleep patterns in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Su-Hyun Han, Seo-Young Lee, Jae Wook Cho, Jee Hyun Kim, Hye-jin Moon, Hea Ree Park, Yong Won Cho
Summary: This study aimed to investigate the relationship between COVID-19 or vaccination history and sleep and circadian patterns. The results showed that individuals with a history of COVID-19 had a later chronotype, and those who experienced vaccine-related side effects had poorer sleep quality. Therefore, COVID-19 and vaccine side effects have an impact on sleep and circadian patterns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Alexander Borbely
Summary: The two-process model is an important conceptual framework in sleep science, which explores the gradients of sleep states and the factors influencing sleep activity levels through animal experiments and sleep deprivation experiments, and extends sleep regulation to the synaptic level and the domains of transcriptome and proteome.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Wan-Ju Cheng, Liang-Wen Hang, Tomohide Kubo, Paivi Vanttola, Sheng-Che Huang
Summary: The study aimed to examine the effect of sleep timing intervention on sleep quality, attention, and sleepiness at work among night shift workers with shift work disorder. The results showed that participants had longer sleep duration, higher sleep quality, shorter reaction times, and fewer lapses during evening sleep schedules compared to morning sleep schedules. The differences between sleep schedules were most prominent among those with late chronotypes.
Article
Physiology
Simon N. N. Archer, Carla S. S. Moeller-Levet, Emma E. E. Laing, Derk-Jan Dijk
Summary: Cortisol is a strong circadian signal that synchronizes peripheral circadian clocks with the central clock. Misalignment of cortisol rhythm with the sleep-wake cycle can have negative health outcomes, and this study investigated the underlying molecular mechanisms. The researchers induced misalignment between sleep-wake cycle and melatonin and cortisol rhythms in humans and measured blood transcriptomics to understand the impact on gene expression. The results suggest that the disruption of glucocorticoid signaling pathways by mistimed sleep may be mediated by changes in the transcription factor SP1.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Jeanne F. Duffy, Sabra M. Abbott, Helen J. Burgess, Stephanie J. Crowley, Jonathan S. Emens, Lawrence J. Epstein, Karen L. Gamble, Brant P. Hasler, David A. Kristo, Roneil G. Malkani, Shadab A. Rahman, S. Justin Thomas, James K. Wyatt, Phyllis C. Zee, Elizabeth B. Klerman
Summary: This White Paper presents the results of a workshop co-sponsored by the Sleep Research Society (SRS) and the Society for Research on Biological Rhythms (SRBR) to identify gaps in diagnosis and treatment, and areas of high-priority research in circadian rhythm sleep-wake disorders. CRSWD are caused by alterations in the circadian time-keeping system and may affect a large number of individuals in the United States.
Article
Biochemical Research Methods
Wei Wang, Robin K. Yuan, Jude F. Mitchell, Kirsi-Marja Zitting, Melissa A. St Hilaire, James K. Wyatt, Frank A. J. L. Scheer, Kenneth P. Wright, Emery N. Brown, Joseph M. Ronda, Elizabeth B. Klerman, Jeanne F. Duffy, Derk-Jan Dijk, Charles A. Czeisler
Summary: Circadian clocks drive cyclic variations in many aspects of physiology, but it is often important to quantify the relative contributions of these factors. Nathaniel Kleitman's forced desynchrony (FD) protocol was designed to assess endogenous circadian rhythmicity and to separate circadian from evoked components of daily rhythms.
Article
Clinical Neurology
Lei Yue, Naixue Cui, Li Jiang, Naisong Cui
Summary: This study examined the mediating effect of chronotype and social jetlag in the relationship between screen use before sleep and emotional problems. The results showed that adolescents who reported screen use before sleep exhibited later chronotype and greater social jetlag, which in turn were associated with higher levels of emotional problems. The serial indirect effect of chronotype and social jetlag explained 6.2%-16.7% of the total effect of screen use before sleep on emotional problems.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Genetics & Heredity
Chaoran Liu, Xiangrong Tang, Zishan Gong, Wang Zeng, Qiao Hou, Renbin Lu
Summary: Nearly all living organisms have an internal circadian oscillation with a periodicity of approximately 24 hours. Misalignment between circadian rhythms and external environment can lead to circadian rhythm sleep disorders (CRSD), which have been found to be associated with adverse health consequences. Recent studies have made progress in understanding the genetic basis and pathological mechanisms of CRSD, particularly in advanced sleep-wake phase disorder (ASPD) and delayed sleep-wake phase disorder (DSPD).
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Jeanne F. Duffy, Wei Wang, Joseph M. Ronda, Charles A. Czeisler
Summary: Aging is associated with changes in sleep, and improving sleep can have important consequences for the health and quality of life of older adults. Melatonin, especially at higher doses, may be a viable option for sleep aid in older adults, as it can increase sleep efficiency during both the day and night.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Angela Montaruli, Lucia Castelli, Antonino Mule, Raffaele Scurati, Fabio Esposito, Letizia Galasso, Eliana Roveda
Summary: Circadian rhythm is crucial in regulating key biological functions, with individual chronotypes influencing preferred times for activity and sleep, impacting health differently. Understanding and addressing these differences helps reduce risks of diseases and sleep disorders.
Article
Biology
Michitaka Yoshimura, Shingo Kitamura, Norihito Eto, Akiko Hida, Ruri Katsunuma, Naoko Ayabe, Yuki Motomura, Yuji Nishiwaki, Kazuno Negishi, Kazuo Tsubota, Kazuo Mishima
Summary: This study measured the light irradiance at eye and wrist levels in different wavelength bands under laboratory conditions simulating daily life. The results showed that the average irradiance at eye level was lower than at wrist level, and the blue light irradiance at eye level was significantly correlated with circadian phase shift. Therefore, quantitative measurements of wavelength spectra at eye level are necessary to assess the effect of ambient light on the human biological clock.
BIOLOGICAL RHYTHM RESEARCH
(2022)
Article
Clinical Neurology
Maria Korman, Vadim Tkachev, Catia Reis, Yoko Komada, Shingo Kitamura, Denis Gubin, Vinod Kumar, Till Roenneberg
Summary: In this study, changes in wellbeing during COVID-19 social restrictions were investigated, and their relationship with outdoor daylight exposure and sleep-wake behavior was analyzed. The results showed that sleep quality, quality of life, physical activity, and productivity declined during social restrictions, while screen time increased and outdoor daylight exposure decreased. However, some participants reported no changes or even improvements. Larger reductions in outdoor daylight exposure were associated with poorer wellbeing and delayed mid-sleep times.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Yu Itoh, Masahiro Takeshima, Yoshitaka Kaneita, Naohisa Uchimura, Yuichi Inoue, Makoto Honda, Wataru Yamadera, Norio Watanabe, Shingo Kitamura, Isa Okajima, Naoko Ayabe, Kyoko Nomura, Kazuo Mishima
Summary: This study demonstrates a significant increase in the prevalence of insomnia after earthquakes. Furthermore, individuals with insomnia are more likely to experience psychological distress that continues until 2012.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Behavioral Sciences
Sayuri Hayashi, Yuki Nishimura, Yuki Ikeda, Hiroki Nakashima, Yuka Egashira, Masatoshi Ukezono, Shota Uono, Takashi Okada, Shigekazu Higuchi
Summary: This study investigated the effect of aesthetic preference on neural activities in response to walking motion, suggesting that aesthetic preference enhances the later integrational process of motion, while the early perceptual process is potentially modulated by familiarity rather than aesthetic preference.
Article
Physiology
Michihiro Ohashi, Sang-il Lee, Taisuke Eto, Nobuo Uotsu, Chie Tarumizu, Sayuri Matsuoka, Shinobu Yasuo, Shigekazu Higuchi
Summary: The study suggests that intake of l-serine before bedtime for multiple days may attenuate circadian phase delay in real life, and this effect does not depend on the initial circadian phase.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Article
Physiology
Minori Enomoto, Shingo Kitamura, Kyoko Nakazaki
Summary: This study formulated an algorithm for discriminating sleep/wake states in school-aged children using the FS-760 actigraph and evaluated its validity. The results showed a high agreement rate for the developed algorithm, but a lower agreement rate when applying the adult algorithm to children. Hence, the establishment and validation of population-specific algorithms are necessary.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Article
Clinical Neurology
Masahiro Takeshima, Kazuhisa Yoshizawa, Minori Enomoto, Masaya Ogasawara, Mizuki Kudo, Yu Itoh, Naoko Ayabe, Yoshikazu Takaesu, Kazuo Mishima
Summary: This study aimed to examine the effect of Japanese policies and novel hypnotics on long-term prescriptions of hypnotics. The results showed that Japanese policies had no statistically significant effect on long-term prescriptions of hypnotics. However, initiating orexin receptor antagonists may be a potential strategy to prevent long-term prescriptions of hypnotics.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Physiology
Taisuke Eto, Shingo Kitamura, Kana Nishimura, Kota Takeoka, Yuki Nishimura, Sang-il Lee, Michihiro Ohashi, Akiko Shikano, Shingo Noi, Shigekazu Higuchi
Summary: Camping with advanced sleep and wake timing under natural sunlight can advance children's circadian phases. However, DLMO earlier than sunset in an early waking condition may lead to large interindividual variability in the circadian rhythm phase.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Letter
Clinical Neurology
Akiko Hida, Aritoshi Iida, Motoki Ukai, Hiroshi Kadotani, Makoto Uchiyama, Takashi Ebisawa, Yuichi Inoue, Shingo Kitamura, Kazuo Mishima
Review
Physiology
Taisuke Eto, Shigekazu Higuchi
Summary: The physiological effects of light exposure in humans are diverse, including the non-visual effects such as circadian rhythm phase shift, melatonin suppression, and pupillary light reflex. Age-related differences in non-visual effects have been studied in various research fields, but the results are still inconclusive. Some studies have shown differences in non-visual functions among different age groups, while others have found no differences. Factors such as senile constriction, crystalline lens opacity, and compensatory mechanisms have been suggested as potential contributors to these differences. More comparative studies with a wide range of ages and controlled variables are needed to further understand the age-related differences in the non-visual effects of light.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2023)
Article
Clinical Neurology
Masaya Ogasawara, Masahiro Takeshima, Shumpei Kosaka, Aya Imanishi, Yu Itoh, Dai Fujiwara, Kazuhisa Yoshizawa, Norio Ozaki, Kazuyuki Nakagome, Kazuo Mishima
Summary: This study tested the performance of three sleep-tracking devices against polysomnography (PSG) in patients with psychiatric disorders. The results showed that the portable EEG device (Sleepgraph) had the best sleep stage-tracking performance, while the consumer sleep device (Fitbit Sense) exhibited poor sleep stage-tracking performance in patients with psychiatric disorders.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Clinical Neurology
Taisuke Eto, Shingo Kitamura, Akiko Shikano, Kosuke Tanabe, Shigekazu Higuchi, Shingo Noi
Summary: This study aimed to establish a method for estimating dim light melatonin onset (DLMO) in children using mathematical slopes calculated from melatonin concentrations at three sampling points before and after sleep. The results showed that DLMO could be accurately estimated from salivary melatonin levels at three time points before and after sleep in children.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)