Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Alessandro Miola, Giulia Cattarinussi, Gilberto Antiga, Stefano Caiolo, Marco Solmi, Fabio Sambataro
Summary: Research indicates that specific emotional regulation abnormalities exist in BD patients, but their magnitude is smaller compared to BPD. Future therapeutic interventions should focus on targeting emotional regulation strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Hanne Lie Kjaerstad, Viktoria Damgaard, Gitte M. Knudsen, Maj Vinberg, Lars Vedel Kessing, Julian Macoveanu, Kamilla W. Miskowiak
Summary: This study aims to assess the neural underpinnings of potential subgroups of bipolar disorder patients and found two distinct patient subgroups with different patterns of neural activity and relapse risk. Heightened amygdala reactivity was associated with increased risk of relapse.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Andrew J. Ross, Alexandra L. Roule, Christen M. Deveney, Kenneth E. Towbin, Melissa A. Brotman, Ellen Leibenluft, Wan-Ling Tseng
Summary: In response to frustration, youths with bipolar disorder (BD) exhibit positive connectivity between the inferior frontal gyrus (IFG) and ventromedial prefrontal cortex (vmPFC) but lack negative connectivity between the striatum and insula. Following frustration, BD youths show elevated connectivity between the IFG and parahippocampal gyrus (PHG)/periaqueductal gray (PAG) and decreased connectivity between the amygdala and cerebellum during attention orienting.
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Wen Lin Teh, Jianlin Liu, Nisha Chandwani, Yu Wei Lee, Phern-Chern Tor, Mythily Subramaniam, Roger C. Ho
Summary: This study aimed to establish the clinical relevance of emotional urgency in bipolar disorders. The results showed that emotional urgency had a significant impact on bipolar symptoms, while non-emotional impulsivity subdimensions had smaller effects and were not significant factors in the regression models. Additionally, individuals with a history of attempted suicide had higher levels of emotional urgency.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Lisa T. Eyler, Farren B. S. Briggs, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit H. Mulsant, Sigfried Schouws, Nadine P. G. Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Martha Sajatovic
Summary: This study analyzed the symptom mixity in older-age bipolar disorder (OABD) and its association with everyday function. The results showed that mixed features are predominant in OABD and are associated with worse everyday function. Among those with mixed symptoms, the severity of depression is the main driver of poorer functioning.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Substance Abuse
Zachary W. Adams, Jon Agley, Casey A. Pederson, Lauren A. Bell, Matthew C. Aalsma, TiAura Jackson, Miyah T. Grant, Carol A. Ott, Leslie A. Hulvershorn
Summary: This study evaluated an innovative education program aimed at disseminating specialized knowledge and improving attitudes towards providing M-OUD in justice settings. Participants showed increased knowledge about OUD and viewed the treatment as more practical after the program. Cases presented during the program typically involved complex medical and psychiatric comorbidities, and recommendations addressed several themes including harm reduction, post-release supports, and integration of treatments.
Article
Clinical Neurology
Monica Federoff, Michael J. McCarthy, Amit Anand, Wade H. Berrettini, Holli Bertram, Abesh Bhattacharjee, Cynthia Calkin, Carla Conroy, William H. Coryell, Nicole D'Arcangelo, Anna DeModena, Carrie Fisher, Scott Feeder, Nicole Frazier, Mark A. Frye, Keming Gao, Julie Garnham, Elliot S. Gershon, Ney Alliey-Rodriguez, Kara Glazer, Fernando Goes, Toyomi Karberg, Gloria Harrington, Petter Jakobsen, Masoud Kamali, Marisa Kelly, Susan G. Leckband, Falk Lohoff, Adam X. Maihofer, Melvin G. McInnis, Francis Mondimore, Gunnar Morken, John Nurnberger, Ketil J. Oedegaard, Megan Ritchey, Kelly Ryan, Martha Schinagle, Helle Schoeyen, Candice Schwebel, Martha Shaw, Paul D. Shilling, Claire Slaney, Andrea Stautland, Bruce Tarwater, Joseph R. Calabrese, Martin Alda, Caroline M. Nievergelt, Peter P. Zandi, John R. Kelsoe
Summary: Exposure to lithium is associated with reduced circadian disruption, and lithium response at 12 weeks was selectively associated with the reduction of circadian depressive symptoms.
Article
Psychology, Developmental
Yun Wang, Ellen Kessel, Seonjoo Lee, Susie Hong, Elizabeth Raffanello, Leslie A. Hulvershorn, Amy Margolis, Bradley S. Peterson, Jonathan Posner
Summary: The therapeutic effects of psychostimulants in treating ADHD are associated with changes in dynamic functional connectivity rather than static functional connectivity. This finding may have important implications for the development of new ADHD interventions.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Pediatrics
Alexander P. Oliver, Lauren A. Bell, Jon Agley, Kristina Bixler, Leslie A. Hulvershorn, Zachary W. Adams
Summary: As adolescent vaping becomes increasingly prevalent in the United States, it is crucial for pediatric clinicians to have access to best practices in screening, assessing, and treating vaping-related substance use. The Teen Vaping ECHO program offers practical learning sessions to improve the clinical management of adolescent vaping. This study demonstrates that the program effectively enhances participants' knowledge, attitudes, and practices, leading to increased comfort in discussing vaping with patients and implementing effective screening strategies.
CLINICAL PEDIATRICS
(2022)
Editorial Material
Psychology, Developmental
Joseph Aloi, Leslie Hulvershorn
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Sonia Hesam-Shariati, Bronwyn J. Overs, Gloria Roberts, Claudio Toma, Oliver J. Watkeys, Melissa J. Green, Kerrie D. Pierce, Howard J. Edenberg, Holly C. Wilcox, Emma K. Stapp, Melvin G. McInnis, Leslie A. Hulvershorn, John I. Nurnberger, Peter R. Schofield, Philip B. Mitchell, Janice M. Fullerton
Summary: This study explores the epigenetic signatures in young people at high familial risk of bipolar disorder. The findings suggest that BD-PRS has a broad impact on epigenetic processes and converges with genes associated with BD, schizophrenia, chronotype, and risk taking. Additionally, a differentially methylated probe in the mitochondrial aminoacyl-tRNA synthetase VARS2 remains significantly hypomethylated in the high BD-PRS group.
TRANSLATIONAL PSYCHIATRY
(2022)
Meeting Abstract
Psychology, Developmental
Alexander P. Oliver, Lauren A. Bell, Jon Agley, Kristina Bixler, Leslie A. Hulvershorn, Zachary W. Adams
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Meeting Abstract
Psychology, Developmental
Joseph Aloi, Shubhavi Arya, Kathleen I. Crum, Mario Dzemidzic, Leslie A. Hulvershorn
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Zachary W. Adams, Brigid R. Marriott, Leslie A. Hulvershorn, Jesse Hinckley
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Article
Psychiatry
Anthony J. Perkins, Rezaul Khandker, Ashley Overley, Craig A. Solid, Farid Chekani, Anna Roberts, Paul Dexter, Malaz A. Boustani, Leslie Hulvershorn
Summary: Non-adherence to psychotropic medications is common in schizophrenia and bipolar disorders (BDs) and is associated with high acute care utilization, according to a study analyzing electronic health record data of individuals with these illnesses.
Article
Psychology, Developmental
Kyle A. Kercher, Jesse A. Steinfeldt, Devin J. Rettke, Taylor R. Zuidema, Miata J. Walker, Vanessa M. Martinez Kercher, Patricia Silveyra, Dong-Chul Seo, Jonathan T. Macy, Leslie A. Hulvershorn, Keisuke Kawata
Summary: The study examined the impact of one season of head impact exposure, age of first exposure to football, and psychological need satisfaction on acute mental health outcomes in adolescent football players. The results showed that cumulative head impact exposure and age of first exposure were not related to acute mental health outcomes, but greater psychological satisfaction was associated with reduced depressive and anxiety symptoms and increased thriving scores.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Article
Psychology, Clinical
Elizabeth Kwon, Mathew C. Aalsma, Tamika C. B. Zapolski, Patrick O. Monahan, Leslie Hulvershorn
Summary: This study examined the determinants of early dating behaviors and found impulsivity to be a significant factor. Adolescents with higher levels of sensation seeking and negative urgency were more likely to engage in early dating behaviors. Additionally, being female, having higher parental education, and advanced pubertal development were associated with lower risk of initiating early dating.
ARCHIVES OF SEXUAL BEHAVIOR
(2023)
Article
Health Care Sciences & Services
Matthew C. Aalsma, Zachary W. Adams, Michael P. Smoker, Brigid R. Marriott, Fangqian Ouyang, Emily Meudt, Leslie A. Hulvershorn
Summary: This study describes a 2-year statewide training initiative that aimed to address the availability and accessibility gap of evidence-based treatments (EBTs) in community substance use disorder (SUD) treatment. The initiative trained therapists in motivational enhancement/cognitive behavioral therapy (MET/CBT) through workshops, clinical consultation, fidelity monitoring, readings, and online resources. The study found that therapists reported increased confidence in implementing MET/CBT and showed improvement in MI and CBT knowledge.
JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH
(2023)
Meeting Abstract
Neurosciences
Susan Conroy, Tarah Butcher, Mario Dzemidzic, Brandon Oberlin, Leslie Hulvershorn
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Kathleen Crum, Joseph Aloi, Nikhil Shah, Michael Smoker, Leslie Hulvershorn
BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)