Article
Clinical Neurology
Lijun Zhang, Guo Li, Meiyan Liu
Summary: This meta-analysis aimed to explore the association between SSRIs and blood pressure in patients with CVD and depression. The results showed that SSRIs had no effect on SBP and DBP overall, but significantly lowered DBP in hypertensive patients. Further research is needed to understand the potential mechanisms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Veterinary Sciences
Heba A. Sharawy, Abdel Raouf O. Hegab, Engy F. Risha, Mohamed El-Adl, Walid T. Soliman, Mohamed A. Gohar, Reham A. Fahmy, Virginia M. Farag, Kazuhiko Imakawa, Fuller W. Bazer, Daniela James, Adel Zaghloul, Abdelnasser A. Abdalla, Mariam M. Rabie, Mohammed A. Elmetwally
Summary: This study investigated changes in uterine and vaginal blood flow during the Ovsynch program for synchronization of estrus in Holstein cows using noninvasive color Doppler ultrasound. The results showed that vaginal and uterine blood flow were two determinant factors for higher conception rates in Holstein dairy cows.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Piengbulan Yapan, Suphaphon Tachawatcharapunya, Supitchaya Surasereewong, Piyatida Thongkloung, Julaporn Pooliam, Liona C. Poon, Tuangsit Wataganara
Summary: This study aimed to investigate the impact of a history of previous Cesarean delivery (CD) on uterine artery (UtA) Doppler indices throughout pregnancy. The results showed no difference in the measurements and temporal changes of UtA Doppler indices between women with and without CD. The study found that the Delta values of UtA Doppler indices exhibited a biphasic pattern, decreasing until the second trimester and then increasing.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Mair Zamir, D. Michael Nelson, Yehuda Ginosar
Summary: During pregnancy, a major increase in uteroplacental blood flow is achieved through the geometric transformation of uterine spiral arteries and trophoblast invasion, which significantly reduces resistance to flow, critical for normal pregnancy. Our research identifies key variables in this hemodynamic change and establishes a numerical threshold for adequate trophoblast invasion, potentially serving as a diagnostic marker for high-risk pregnancies in the future.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Oncology
Fang Li, Jing Chen, Li Yin, Dingyuan Zeng, Li Wang, Hua Tao, Xiajuan Wu, Feng Wei, Fan Xu, Qiuling Shi, Zhong Lin, Zhibiao Wang
Summary: This study compared the pregnancy outcomes of high-intensity focused ultrasound ablation (HIFU), myomectomy, and uterine artery embolization (UAE) for fertility-sparing patients with uterine fibroids and investigated the possible mechanism of improving pregnancy by HIFU. The results showed that myomectomy had a higher pregnancy rate than HIFU and UAE, while the miscarriage rate of HIFU was similar to myomectomy and UAE. Subgroup analysis suggested that ultrasound-guided HIFU (USgHIFU) may have more ideal pregnancy outcomes than magnetic resonance imaging-guided HIFU. In conclusion, HIFU, especially USgHIFU, may serve as an alternative fertility-sparing modality for patients with uterine fibroids over 40 years old and improve pregnancy rates by elevating uterine blood flow impedance.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Reproductive Biology
Jay S. Mishra, Sathish Kumar
Summary: Preeclampsia and testosterone-induced gestational hypertension models show upregulation of AT(1)R and downregulation of AT(2)R, increasing AT(2)R activity could help restore the balance between AT(1)R and AT(2)R and improve gestational vascular function.
BIOLOGY OF REPRODUCTION
(2021)
Article
Psychiatry
Laura Ramo-Fernandez, Anja M. Gumpp, Christina Boeck, Sabrina Krause, Alexandra M. Bach, Christiane Waller, Iris-Tatjana Kolassa, Alexander Karabatsiakis
Summary: This study investigated the intergenerational effects of maternal childhood maltreatment exposure on DNA methylation and OXTR gene expression. The interplay of single nucleotide polymorphisms and DNAm on the regulation of oxytocinergic signaling was shown. The study also suggests that the intergenerational comparability of OXTR DNAm might be altered in infants of mothers who experienced childhood maltreatment.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Laurentiu Craciunas, Nikolaos Zdoukopoulos, Suganthi Vinayagam, Lamiya Mohiyiddeen
Summary: This study investigates the effectiveness and safety of different hormonal regimens on uterine and endometrial development in women with POI. Three studies were included, but due to small sample sizes, meta-analysis was not feasible, resulting in very low-certainty evidence.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Psychology, Developmental
Joan Luby, Meghan Rose Donohue, Kirsten Gilbert, Rebecca Tillman, Deanna M. Barch
Summary: The study demonstrates that Parent Child Interaction Therapy Emotion Development (PCIT-ED) has sustained effects on depression, parenting stress, and parental depression in young children, with high rates of sustained remission and reduced relapse after 18 weeks. Results indicate that parental response to child expression of emotion may drift back towards baseline after 3 months, with predictors of relapse including externalizing disorder, co-morbid disorders, and poorer guilt reparation and emotion regulation. The relatively low relapse rate after 18 weeks is comparable or better than many empirically proven treatments for depression in older children.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Behavioral Sciences
Kristina Belovic, Eva Simoncicova, Mireia Vinas Noguera, Michal Dubovicky, Eszter Bogi
Summary: Preclinical studies suggest that stress-related disorders prior gestation can cause long-term changes in neurobehavioral adaptations, with antidepressant therapy potentially reversing negative effects on offspring. The study found that pre-gestational stress and venlafaxine therapy had impacts on juvenile and adolescent behavior, with venlafaxine treatment in adulthood normalizing anxiety-like behavior in females. Additionally, maternal stress prior gestation can have long-term impacts on the number of hippocampal immature neurons in female offspring.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dezheng Zhou, Zhenshu Li, Yue Sun, Jing Yan, Guowei Huang, Wen Li
Summary: This study aimed to evaluate the effects of early life stage folic acid deficiency on neurodevelopment and cognitive function in offspring rats. The results showed that folic acid deficiency had inhibiting effects on neurodevelopment and cognitive function, while folic acid supplementation had protective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Vincent Chin-Hung Chen, Shu- Wu, Chiao-Fan Lin, Mong-Liang Lu, Yi-Lung Chen, Robert Stewart
Summary: This cohort study suggests that prenatal benzodiazepine exposure may be associated with neurodevelopmental disorders among children, which could be accounted for by maternal genetic confounding.
Article
Psychiatry
Megan Galbally, Stuart J. Watson, Olav Spigset, Philip Boyce, Tim F. Oberlander, Andrew J. Lewis
Summary: This study examined the impact of exposure to antidepressants during pregnancy on child motor development. The findings suggest a mixed association between sensorimotor development and antidepressant use, with potential implications for visuospatial processing. Further exploration of these associations is warranted.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Hossam R. El-Sherbiny, Haney Samir, Amr S. El-Shalofy, Elshymaa A. Abdelnaby
Summary: This study examined the effect of L-arginine administration on uterine haemodynamics and uteroplacental thickness in pregnant buffaloes under heat stress conditions. The results showed that L-arginine improved uterine blood flow, increased nitric oxide levels and steroid production, which could enhance foetal growth and development.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Medicine, Research & Experimental
Ana Flavia Quiarato Lozano, Mayara Silva Moura, Bruna Marques Tavares, Wilma De Grava Kempinas
Summary: The study found that exposure to sertraline during pregnancy affected the somatic, reflex, and neurobehavioral development of offspring, with delays in teeth eruption and fur development, as well as reduced exploratory behavior compared to control groups.
Article
Pediatrics
Traci A. Bekelman, Emily A. Knapp, Yanan Dong, Dana Dabelea, Tracy M. Bastain, Carrie Breton, Kecia N. Carroll, Carlos A. Camargo, Ann M. Davis, Anne L. Dunlop, Amy J. Elliott, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, Diane Gilbert-Diamond, Frank D. Gilliland, Monique M. Hedderson, Alison E. Hipwell, Christine W. Hockett, Kathi C. Huddleston, Margaret R. Karagas, Nichole Kelly, Jin-Shei Lai, Barry M. Lester, Maristella Lucchini, Melissa M. Melough, Nicole L. Mihalopoulos, T. Michael O'Shea, Andrew G. Rundle, Joseph B. Stanford, Sara VanBronkhorst, Rosalind J. Wright, Qi Zhao, Katherine A. Sauder
Summary: Societal changes during the COVID-19 pandemic may affect children's health behaviors. Parents experiencing financial strain may need additional support to promote healthy behaviors. Changing work schedules to care for children can lead to shorter screen time and longer sleep duration.
Article
Biology
Changgee Chang, Zhiqi Bu, Qi Long
Summary: Electronic health records (EHRs) provide opportunities for precision medicine, but sharing data is a challenge. We propose a method that aggregates data from external sites by treating it as missing data. We also suggest incorporating posterior samples from remote sites to improve parameter estimates.
Article
Statistics & Probability
Kan Chen, Siyu Heng, Qi Long, Bo Zhang
Summary: One central goal of observational study design is to incorporate non-experimental data into an approximate randomized controlled trial using statistical matching. However, residual imbalance due to imperfect matching of observed covariates often persists. This article presents two generic classes of exact statistical tests for a biased randomization assumption and introduces a quantity called residual sensitivity value (RSV) as a means to quantify the level of residual confounding due to imperfect matching of observed covariates in a matched sample. The proposed methodology is demonstrated through a re-examination of a famous observational study.
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2023)
Review
Neurosciences
Claudia Lugo Candelas, Ardesheer Talati, Caila Glickman, Mariely Hernandez, Pamela Scorza, Catherine Monk, Ai Kubo, Chiaying Wei, Andre Sourander, Cristiane S. Duarte
Summary: Studies on prenatal interventions for reducing the risk of psychiatric disorders in offspring have provided mixed and limited evidence. Most research has focused on reducing prenatal depression and anxiety, with some positive effects observed. However, there is a lack of studies on offspring mental health and neurodevelopmental outcomes. More randomized controlled trials focusing on these outcomes are urgently needed.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Marion I. van den Heuvel, Catherine Monk, Cassandra L. Hendrix, Jasmine Hect, Seonjoo Lee, Tianshu Feng, Moriah E. Thomason
Summary: This study found that maternal experiences of childhood maltreatment are associated with fetal brain development, particularly in the left hemisphere. The findings suggest that the intergenerational transmission of trauma may occur prior to birth.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Alison E. Hipwell, Irene Tung, Phillip Sherlock, Xiaodan Tang, Kim McKee, Monica McGrath, Akram Alshawabkeh, Tracy Bastain, Carrie V. Breton, Whitney Cowell, Dana Dabelea, Cristiane S. Duarte, Anne L. Dunlop, Assiamira Ferrera, Julie B. Herbstman, Christine W. Hockett, Margaret R. Karagas, Kate Keenan, Robert T. Krafty, Catherine Monk, Sara S. Nozadi, Thomas G. O'Connor, Emily Oken, Sarah S. Osmundson, Susan Schantz, Rosalind Wright, Sarah S. Comstock
Summary: This study investigated the impact of the COVID-19 pandemic on pregnant women and birth outcomes using a quasi-experimental design. The results showed a small effect of pandemic exposure on shorter gestational age at birth, but no impact on birthweight adjusted for gestational age. Pregnant women during the pandemic reported higher levels of prenatal stress and depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Oncology
Xinhe Shan, Qi Long, Alfred L. Garfall, Sandra P. Susanibar-Adaniya
BLOOD CANCER JOURNAL
(2023)
Review
Psychiatry
Clare McCormack, Sameera Abuaish, Catherine Monk
Summary: This review synthesizes recent evidence on the relationship between immune system activity and perinatal depression, highlighting the role of dysregulated immune functioning as a potential risk factor.
CURRENT PSYCHIATRY REPORTS
(2023)
Article
Medicine, General & Internal
Morgan R. Firestein, Lauren C. Shuffrey, Yunzhe Hu, Margaret Kyle, Maha Hussain, Catherine Bianco, Violet Hott, Sabrina P. Hyman, Mia Kyler, Cynthia Rodriguez, Melanie Tejeda Romero, Helen Tzul Lopez, Carmela Alcantara, Dima Amso, Judy Austin, Jennifer M. Bain, Jennifer Barbosa, Ashley N. Battarbee, Ann Bruno, Sharon Ettinger, Pam Factor-Litvak, Suzanne Gilboa, Sylvie Goldman, Cynthia Gyamfi-Bannerman, Panagiotis Maniatis, Rachel Marsh, Tyler Morrill, Mirella Mourad, Rebecca Muhle, Gabriella Newes-Adeyi, Kimberly G. Noble, Kally C. O'Reilly, Anna A. Penn, Lawrence Reichle, Ayesha Sania, Vera Semenova, Wendy G. Silver, Grace Smotrich, Alan T. Tita, Nim Tottenham, Michael Varner, Martha G. Welch, Noelia Zork, Donna Garey, William P. Fifer, Melissa S. Stockwell, Catherine Monk, Fatimah Dawood, Dani Dumitriu
Summary: This study examined the association between mild or asymptomatic maternal SARS-CoV-2 infection during pregnancy and infant neurodevelopmental differences. The results showed no significant association between prenatal exposure to maternal SARS-CoV-2 infection and infant neurodevelopment. These findings are important for public health, especially for pregnant individuals who experience asymptomatic or mild COVID-19 infections.
Article
Psychology, Multidisciplinary
Sarka Kankova, Lea Takacs, Jana Hlavacova, Pavel Calda, Catherine Monk, Jan Havlicek
Summary: In this study, it was found that pregnant women during the COVID-19 pandemic had higher levels of disgust sensitivity compared to those before the pandemic. This effect was stronger in primiparae and decreased with age. However, no significant differences were found in terms of nausea and vomiting between women pregnant before and during the pandemic.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Educational
Lauren C. Shuffrey, Santiago Morales, Melanie H. Jacobson, Michelle Bosquet Enlow, Akhgar Ghassabian, Amy E. Margolis, Maristella Lucchini, Kecia N. Carroll, Rosa M. Crum, Dana Dabelea, Arielle Deutsch, William P. Fifer, Brandon Goldson, Christine W. Hockett, W. Alex Mason, Lisette T. Jacobson, Thomas G. O'Connor, Nicolo Pini, Yael Rayport, Ayesha Sania, Leonardo Trasande, Rosalind J. Wright, Seonjoo Lee, Catherine Monk
Summary: This study investigated the relationship between gestational diabetes mellitus (GDM), prenatal and postnatal maternal depressive symptoms, and externalizing, internalizing, and autism spectrum problems in preschool-aged children. The data was collected from the NIH ECHO Program from 2009 to 2021. The results showed that GDM, prenatal, and postnatal maternal depressive symptoms were all associated with increased child externalizing and internalizing problems. GDM was specifically linked to increased autism behaviors in children exposed to high levels of perinatal maternal depressive symptoms, and this association was found only in males.
Article
Psychology, Developmental
Chiara Sacchi, Pietro De Carli, Camilla Gregorini, Catherine Monk, Alessandra Simonelli
Summary: This study examines the impact of COVID-19 pandemic on the mental health of pregnant women and infants. It finds that maternal prenatal and postpartum mental health are associated with infants' negative affect. The study also highlights the importance of psychological support for pregnant women during the pandemic.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)
Article
Obstetrics & Gynecology
Saundra M. Albers, Timothy Wen, Catherine Monk, Teresa C. Logue, Mary E. D'Alton, Whitney A. Booker, Alexander M. Friedman
Summary: This study found an increasing trend of postpartum psychosis during delivery hospitalizations and postpartum readmissions, which is associated with a wide range of obstetrical and medical comorbidities. Diagnosis of postpartum psychosis is related to various factors, including psychiatric disorders, autoimmune disorders, and substance use disorders.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Psychology, Biological
Akina Umemoto, Zhixin Zhou, Emma M. Millon, Christina S. Koshy, Sydney M. Taylor, Marisa N. Spann, Catherine Monk, Rachel Marsh, Anthony J. Rosellini, Randy P. Auerbach
Summary: A maternal history of major depressive disorder (MDD) is a known risk factor for depression in children. This study investigated whether altered cognitive control capacity is intergenerationally transmitted and contributes to the developmental pathways of depression. Results showed that children with a maternal history of MDD exhibited heightened sensitivity to error and specific brain oscillations. Mothers' performance on a cognitive task was associated with children's error rate and brain activity. However, there was no direct association between control capacity and child depression symptoms.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Psychiatry
Melanie H. Jacobson, Ghassan B. Hamra, Catherine Monk, Rosa M. Crum, Sudhindra Upadhyaya, Lyndsay A. Avalos, Theresa M. Bastain, Emily S. Barrett, Nicole R. Bush, Anne L. Dunlop, Assiamira Ferrara, Morgan R. Firestein, Alison E. Hipwell, Kurunthachalam Kannan, Johnnye Lewis, John D. Meeker, Douglas M. Ruden, Anne P. Starling, Deborah J. Watkins, Qi Zhao, Leonardo Trasande
Summary: This prospective cohort study aimed to investigate the associations between prenatal exposure to phenols, phthalates, parabens, and triclocarban and postpartum depression (PPD) symptoms. The results suggest that both low molecular weight and high molecular weight phthalates may be associated with PPD, and these chemicals could potentially serve as important modifiable targets for preventive interventions.
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)