Article
Pharmacology & Pharmacy
Georgios Schoretsanitis, Celine Dubath, Claire Grosu, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Nicolas Ansermot, Severine Crettol, Frederik Vandenberghe, Franziska Gamma, Armin Gunten, Kerstin Jessica Plessen, Erich Seifritz, Philippe Conus, Chin B. Eap
Summary: This study assessed the effects of olanzapine on metabolic parameters, and found that high-dose olanzapine treatment may lead to early weight gain, while low-dose treatment is associated with increases in blood lipids and blood pressure. Treatment duration and co-prescription of other medications were also found to be related to weight gain.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Review
Nutrition & Dietetics
Lena Pelissier, Sarah Bagot, Jennifer Lynn Miles-Chan, Bruno Pereira, Yves Boirie, Martine Duclos, Abdul Dulloo, Laurie Isacco, David Thivel
Summary: The present study aimed to systematically review the studies implicating diet restriction and body weight evolution in normal-weight individuals. The findings suggest that dieting could be a major risk factor for long-term weight gain in this population. Observational studies showed a relationship between dieting and significant later weight gain, while the meta-analysis indicated that 'dieters' have a higher body weight than 'non-dieters'. However, caution should be exercised due to methodological heterogeneity and publication bias.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Andrea Costa, Inge van der Stelt, Barbara Reynes, Jadwiga Konieczna, Miquel Fiol, Jaap Keijer, Andreu Palou, Dora Romaguera, Evert M. van Schothorst, Paula Oliver
Summary: This study aimed to identify PBMC transcriptomic biomarkers predictive of metabolic impairment related to increased adiposity. The study found 1072 DEGs in OW-OB versus NW and 992 in MONW versus NW. Remarkably, OW-OB and MONW phenotypes share 257 DEGs regulated in the same direction, including the up-regulated gene CXCL8, which may serve as a potential marker for predicting increased metabolic risk.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Rizaldy C. Zapata, Dinghong Zhang, Besma Chaudry, Olivia Osborn
Summary: Preclinical studies in mice often use invasive protocols to deliver drugs, which can impact metabolic parameters. An alternative approach is to mix drugs with highly palatable food, allowing mice to self-administer them and reduce stress. This method enables reliable and rapid drug intake compared to traditional injection or gavage methods.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Neurosciences
Ye Yang, Yujun Long, Dongyu Kang, Chenchen Liu, Jingmei Xiao, Renrong Wu, Jingping Zhao
Summary: The study suggests that probiotics may reduce olanzapine-induced weight gain at the early stage of treatment and delay olanzapine-induced appetite increase. However, this difference disappears at 8 and 12 weeks of treatment.
PSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ghulam Md Ashraf, Badrah S. Alghamdi, Fahad S. Alshehri, Mohammad Zubair Alam, Haythum O. Tayeb, Frank Tarazi
Summary: The study found that the antidiabetic drug EMPA effectively attenuated the body weight gain induced by the atypical antipsychotic drug Ola in female Wistar rats. The impact of Ola on female Wistar rats was significantly different from male rats, indicating a potential gender difference in body weight gain caused by antipsychotic drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Berta Mas-Pares, Silvia Xargay-Torrent, Ariadna Gomez-Vilarrubla, Gemma Carreras-Badosa, Anna Prats-Puig, Francis De Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
Summary: Excessive gestational weight gain during pregnancy has negative effects on the health of offspring, which is mediated by epigenetic modifications and changes in gene expression. This study investigated the association between gestational weight gain and DNA methylation in umbilical cord tissue, and examined whether DNA methylation and the expression of corresponding genes were related to obesity-related parameters in 6-year-old children. The results showed that certain methylated CpG sites in umbilical cord tissue were associated with gestational weight gain, and higher levels of methylation in SETD8 and RPTOR genes and lower levels of methylation in SLIT3 gene were associated with an increased risk of obesity in offspring. The findings suggest that epigenetic changes in umbilical cord tissue could be potential early biomarkers for preventing childhood overweight and obesity.
Article
Nutrition & Dietetics
Zainab Akhter, Nicola Heslehurst, Dries Ceulemans, Judith Rankin, Roger Ackroyd, Roland Devlieger
Summary: Prior bariatric surgery is a significant risk factor for delivering small for gestational age (SGA) babies, with factors such as gestational weight gain, receiving nutritional advice, and weight management playing significant roles in influencing the risk of SGA babies.
Article
Pediatrics
Andreas Kakaroukas, Marieke Abrahamse-Berkeveld, Louise Hayes, Richard J. Q. McNally, Janet E. Berrington, Ruurd M. van Elburg, Nicholas D. Embleton
Summary: This study examined the growth and body composition of late and moderate preterm infants based on different feeding methods. The results showed that breastfed infants had lower fat mass and greater lean body mass increase up to 3 months corrected age compared to formula-fed or mixed-fed infants. This emphasizes the importance of supporting breastfeeding in this population.
PEDIATRIC RESEARCH
(2023)
Article
Immunology
Kristine M. Erlandson, Christoph C. Carter, Kathleen Melbourne, Todd T. Brown, Cal Cohen, Moupali Das, Stefan Esser, Hailin Huang, John R. Koethe, Hal Martin, Grace A. McComsey, Chloe Orkin, Frank A. Post, Juergen K. Rockstroh, Paul E. Sax, Hans-Juergen Stellbrink, Laura Waters, Xuelian Wei, Jordan E. Lake
Summary: A pooled analysis of 12 prospective clinical trials found that moderate weight gain was common after ART switch in people living with HIV, with participants who switched off of efavirenz and tenofovir having the greatest weight gain. Further study is needed to understand the biological mechanisms behind these differential effects and their clinical implications.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Food Science & Technology
Mohsen Mazidi, Emily R. Leeming, Jordi Merino, Long H. Nguyen, Somesh Selvachandran, Joan Capdavila Pujal, Tyler Maher, Kirstin Kade, Benjamin Murray, Mark S. Graham, Carole H. Sudre, Jonathan Wolf, Christina Hu, David A. Drew, Claire J. Steves, Sebastien Ourselin, Christopher Gardner, Tim D. Spector, Andrew T. Chan, Paul W. Franks, Rachel Gibson, Sarah E. Berry
Summary: Big data collected through mobile health apps shows that the COVID-19 pandemic has had diverse and extensive impacts on the diets and lifestyles of adults in the United States and the United Kingdom. The study found that disruption of health behaviors was higher in younger, female, and socio-economically deprived individuals, with greater weight loss observed in highly disrupted individuals.
Article
Pharmacology & Pharmacy
Hazel J. Hunt, Kirsteen Donaldson, Mark Strem, Iulia Cristina Tudor, Suzanne Sweet-Smith, Sharan Sidhu
Summary: The study shows that coadministration of miricorilant with olanzapine can alleviate the weight gain and metabolic disturbances caused by olanzapine. This combination may provide a promising option for treating antipsychotic-induced weight gain.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Alqassem Y. Hakami, Razaz Felemban, Rami Ghazi Ahmad, Abdulrahman H. Al-Samadani, Hassan K. Salamatullah, Jamil M. Baljoon, Loay J. Alghamdi, Mostafa H. Ramadani Sindi, Mohamed Eldigire Ahmed
Summary: This study investigated the impact of antipsychotics use on weight gain and found that the concomitant use of metformin may significantly reduce the occurrence of AIWG.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Nami Mohammadian Khonsari, Patricia Khashayar, Ehsan Shahrestanaki, Roya Kelishadi, Sahar Mohammadpoor Nami, Motahar Heidari-Beni, Zahra Esmaeili Abdar, Ozra Tabatabaei-Malazy, Mostafa Qorbani
Summary: This systematic review and meta-analysis showed that normal weight obesity (NWO) increased the odds of cardiometabolic risk factors (CMRFs). These findings indicate the inadequacy of BMI measurement and emphasize the need for body fat assessment for a better obesity risk assessment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychology, Clinical
Ellen E. Fitzsimmons-Craft, Erin C. Accurso, Anna C. Ciao, Ross D. Crosby, Li Cao, Emily M. Pisetsky, Daniel Le Grange, Carol B. Peterson, Scott J. Crow, Scott G. Engel, James E. Mitchell, Stephen A. Wonderlich
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2015)
Article
Psychology, Clinical
Linsey M. Utzinger, Andrea B. Goldschmidt, Ross D. Crosby, Carol B. Peterson, Stephen A. Wonderlich
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2016)
Article
Psychology, Clinical
Jason M. Lavender, Linsey M. Utzinger, Ross D. Crosby, Andrea B. Goldschmidt, Jo Ellison, Stephen A. Wonderlich, Scott G. Engel, James E. Mitchell, Scott J. Crow, Carol B. Peterson, Daniel Le Grange
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2016)
Article
Psychology, Clinical
Linsey M. Utzinger, James E. Mitchell, Li Cao, Ross D. Crosby, Scott J. Crow, Stephen A. Wonderlich, Carol B. Peterson
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2015)
Article
Psychology, Clinical
Lisa M. Ranzenhofer, Scott G. Engel, Ross D. Crosby, Mark Haigney, Micheline Anderson, Jeanne M. McCaffery, Marian Tanofsky-Kraff
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2016)
Article
Psychology, Clinical
Emily K. White, Cortney S. Warren, Li Cao, Ross D. Crosby, Scott G. Engel, Stephen A. Wonderlich, James E. Mitchell, Carol B. Peterson, Scott J. Crow, Daniel Le Grange
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2016)
Article
Dermatology
Susan D. Mathias, Steven R. Feldman, Ross D. Crosby, Hilary H. Colwell, Kelly McQuarrie, Chenglong Han
JOURNAL OF DERMATOLOGICAL TREATMENT
(2016)
Article
Health Care Sciences & Services
Ronette L. Kolotkin, Kishore M. Gadde, Craig A. Peterson, Ross D. Crosby
QUALITY OF LIFE RESEARCH
(2016)
Article
Psychology, Clinical
Jason M. Lavender, Linsey M. Utzinger, Li Cao, Stephen A. Wonderlich, Scott G. Engel, James E. Mitchell, Ross D. Crosby
JOURNAL OF ABNORMAL PSYCHOLOGY
(2016)
Article
Psychiatry
Kathryn H. Gordon, Heather Simonich, Stephen A. Wonderlich, Swati Dhankikar, Ross D. Crosby, Li Cao, Mun Yee Kwan, James E. Mitchell, Scott G. Engel
SUICIDE AND LIFE-THREATENING BEHAVIOR
(2016)
Article
Psychology, Clinical
Sonia Goncalves, Barbara Machado, Catia Silva, Ross D. Crosby, Jason M. Lavender, Li Cao, Paulo P. P. Machado
EUROPEAN EATING DISORDERS REVIEW
(2016)
Article
Psychology, Clinical
Erin C. Accurso, Stephen A. Wonderlich, Ross D. Crosby, Tracey L. Smith, Marjorie H. Klein, James E. Mitchell, Scott J. Crow, Kelly C. Berg, Carol B. Peterson
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2016)
Article
Psychology, Clinical
Jo M. Ellison, Heather K. Simonich, Stephen A. Wonderlich, Ross D. Crosby, Li Cao, James E. Mitchell, Tracey L. Smith, Marjorie H. Klein, Scott J. Crow, Carol B. Peterson
Article
Psychology, Clinical
Catia Silva, Daniel B. Fassnacht, Kathina Ali, Sonia Goncalves, Eva Conceicao, Ana Vaz, Ross D. Crosby, Paulo P. P. Machado
JOURNAL OF HEALTH PSYCHOLOGY
(2015)
Article
Psychology, Clinical
Erin C. Accurso, Ellen E. Fitzsimmons-Craft, Anna Ciao, Li Cao, Ross D. Crosby, Tracey L. Smith, Marjorie H. Klein, James E. Mitchell, Scott J. Crow, Stephen A. Wonderlich, Carol B. Peterson
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2015)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)