Review
Behavioral Sciences
Martina Laetitia Mustroph, G. Rees Cosgrove, Ziv M. Williams
Summary: This review summarizes the evolution of modern ablative surgery for intractable psychiatric disease, discusses various surgical techniques and technologies, and highlights the potential emerging role of MR-guided focused ultrasound in treating psychiatric disorders.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Review
Neurosciences
Nishanth Sadashiva, Manjul Tripathi, Antonio De Salles
Summary: Psychiatric disorders are a hidden pandemic with limited treatment options. Neurosurgical interventions, including stereotactic radiosurgery (SRS), have shown successful treatment in specific psychiatric disorders, improving quality of life and offering a valid alternative for patients with no therapeutic options. SRS is cost-effective and reproducible among specialists, serving as an adjuvant to medical and behavioral treatments. This study reviews the contemporary role of SRS in various psychiatric disorders.
Review
Neurosciences
Pauline Sarah Munchenberg, Eileen M. Joyce, Keith Matthews, David Christmas, Ludvic Zrinzo
Summary: Stereotactic radiofrequency ablation (SRA) may be beneficial for selected patients with refractory major depressive disorder (MDD), and the effect size is clearly defined.
Article
Clinical Neurology
Ying-Fa Chen, Yang-Pei Chang, Wu-Fu Chen, Wei-Che Lin, Yung-Yee Chang, Hui-Chen Lin, Fu-Yuan Shih
Summary: The study retrospectively collected data from 28 PD patients, showing that patients who received iCT had fewer MER tracks and higher surgical accuracy. Further studies are needed to investigate whether iCT can reduce surgical complications and improve surgical outcomes.
WORLD NEUROSURGERY
(2021)
Article
Neuroimaging
Bochao Cheng, Yajing Meng, Yan Zuo, Yi Guo, Xiuli Wang, Song Wang, Ran Zhang, Wei Deng, Yingkun Guo, Gang Ning
Summary: The study found that there are different brain network patterns between rMDD and nrMDD patients, especially in the prefrontal-limbic circuits. These results suggest that neural circuits may play an important role in differentiating between MDD subtypes.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
R. Saman Vinke, Ashok K. Selvaraj, Martin Geerlings, Dejan Georgiev, Aleksander Sadikov, Pieter L. Kubben, Jonne Doorduin, Peter Praamstra, Bastiaan R. Bloem, Ronald H. M. A. Bartels, Rianne A. J. Esselink
Summary: This study evaluated the added value of MER and intraoperative clinical testing in PD-STN-DBS surgery, and found that these steps did not provide additional value in determining final lead position, leading to a change in clinical practice towards an asleep MRI-guided and stereotactic CT-verified approach.
JOURNAL OF PARKINSONS DISEASE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Taihei Itoh, Yuji Ishida, Masaomi Kimura, Hirofumi Tomita
Summary: The ventricular papillary muscles (VPMs) can cause premature ventricular contractions (PVCs). Catheter ablation of VPM PVCs is challenging due to anatomical complexity, such as apical structures near the ventricular walls. The QDOT MICRO catheter with microelectrodes can determine the myocardial activation timing and identify the origin of PVCs near the right ventricular anterior wall, as demonstrated in this repaired truncus arteriosus case.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Andrew Y. Powers, Mauricio B. Pinto, Oliver Y. Tang, Jia-Shu Chen, Cody Doberstein, Wael F. Asaad
JOURNAL OF NEUROSURGERY
(2020)
Review
Critical Care Medicine
Ghazal Aghagoli, Benjamin Gallo Marin, Nicole J. Katchur, Franz Chaves-Sell, Wael F. Asaad, Sarah A. Murphy
Summary: This review synthesizes the literature on the neurological impact of COVID-19, highlighting potential neurologic manifestations and mechanisms, and emphasizes the importance of understanding and mitigating SARS-CoV-2-associated neurologic injury.
NEUROCRITICAL CARE
(2021)
Article
Clinical Neurology
Esther Wu, Siddharth Marthi, Wael F. Asaad
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Nicole C. R. McLaughlin, Peter M. Lauro, Morgan T. Patrick, Francesco G. Pucci, Adriel Barrios-Anderson, Benjamin D. Greenberg, Steven A. Rasmussen, Wael F. Asaad
Summary: This study reported the clinical outcomes and safety profile of using MR-guided LITT for bilateral ventral anterior capsulotomy for OCD. The results showed that LITT ventral capsulotomy was generally well tolerated and effective in most patients, with some adverse effects observed.
Article
Clinical Neurology
Konrad W. Walek, Owen P. Leary, Rahul Sastry, Wael F. Asaad, Joan M. Walsh, Leonard Mermel
Summary: By implementing major changes in EVD protocol, the incidence of EVD-related infections decreased significantly, especially with reductions in both gram-positive and gram-negative bacterial infections. The most significant reduction in incidence was observed when combining reduced EVD sampling frequency, cutaneous antisepsis with alcoholic chlorhexidine, and subcutaneous tunneling of the EVD catheter.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Belinda Shao, Oliver Y. Tang, Owen P. Leary, Hael Abdulrazeq, Rahul A. Sastry, Sarah Brown, Ira B. Wilson, Wael F. Asaad, Ziya L. Gokaslan
Summary: During the COVID-19 pandemic, the demand for neurosurgical acute care increased, with a decrease in consult volume and an increase in the proportion of cases requiring acute operative intervention. It is crucial to maintain capacities for high-acuity nonambulatory neurosurgical care in times of health resource reallocation.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
David D. Liu, Peter M. Lauro, Ronald K. Phillips, Owen P. Leary, Bryan Zheng, Julie L. Roth, Andrew S. Blum, David J. Segar, Wael F. Asaad
Summary: The study suggests that a two-trajectory approach can improve the ablation of relevant medial temporal lobe structures, potentially leading to excellent seizure outcomes. Initial clinical results show that LITT amygdalohippocampotomy performed via two-laser trajectories may be effective in achieving Engel class I outcomes. Further research is needed to confirm the long-term efficacy and safety of this approach.
Article
Neurosciences
Steven D. Targum, Lisa Fosdick, Kristen E. Drake, Paul B. Rosenberg, Anna D. Burke, David A. Wolk, Kelly D. Foote, Wael F. Asaad, Marwan Sabbagh, Gwenn S. Smith, Andres M. Lozano, Constantine G. Lyketsos
Summary: The study suggests that age may play a role in moderating treatment outcomes in Alzheimer's disease trials. Younger AD participants showed faster disease progression, which might be influenced by different AD subtypes. The findings emphasize the importance of biomarker confirmation and genotyping to differentiate AD subtypes in future clinical trials.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Critical Care Medicine
Michael E. Reznik, Roshini Kalagara, Scott Moody, Jonathan Drake, Seth A. Margolis, Sevdenur Cizginer, Ali Mahta, Shyam S. Rao, Christoph Stretz, Linda C. Wendell, Bradford B. Thompson, Wael F. Asaad, Karen L. Furie, Richard N. Jones, Lori A. Daiello
Summary: This study found that in the setting of non-traumatic intracerebral hemorrhage, elevated NLR, high glucose levels, and increased troponin levels were associated with delirium. Elevated NLR specifically predicted delayed-onset delirium and delirium in non-mechanically ventilated patients.
JOURNAL OF CRITICAL CARE
(2021)
Article
Neurosciences
Peter M. Lauro, Shane Lee, Umer Akbar, Wael F. Asaad
Summary: The study discovered distinct neurophysiological characteristics of tremor onset and maintenance in Parkinson's disease. The subthalamic nucleus plays a key role in tremor onset, while control of tremor shifts to cortex in sustained tremor state. Furthermore, changes in directed functional connectivity across sensorimotor cortex distinguish the sustained tremor state.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Konrad W. Walek, Owen P. Leary, Rahul Sastry, Wael F. Asaad, Joan M. Walsh, Jean Horoho, Leonard A. Mermel
Summary: EVD insertion is a common neurosurgical procedure that can lead to complications such as infection. This study identified prior brain surgery, CSF leak, and insertion site dehiscence as risk factors for EVD infection, while the duration of EVD placement was not significantly associated with infection risk.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Review
Clinical Neurology
Bryan Zheng, David D. Liu, Brian B. Theyel, Hael Abdulrazeq, Anna R. Kimata, Peter M. Lauro, Wael F. Asaad
Summary: Epilepsy is a common and debilitating disease of hyperexcitable neural networks. When surgery is not possible, targeting the thalamus as a node for preventing or aborting seizures may be beneficial. A mechanistic framework is needed for thalamic neuromodulation strategies in epilepsy.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Biology
Peter M. Lauro, Shane Lee, Daniel E. Amaya, David D. Liu, Umer Akbar, Wael F. Asaad
Summary: This study decodes the neural activity of patients with Parkinson's disease, revealing distinct neural signatures for tremor and bradykinesia, and demonstrating the importance of signal type and location in understanding these motor states. The results suggest the potential for utilizing neurophysiology to improve the treatment of Parkinson's disease.
Article
Psychiatry
N. C. R. McLaughlin, J. F. Magnotti, G. P. Banks, P. Nanda, M. Q. Hoexter, A. C. Lopes, M. C. Batistuzzo, W. F. Asaad, C. Stewart, D. Paulo, G. Noren, B. D. Greenberg, P. Malloy, S. Salloway, S. Correia, Y. Pathak, J. Sheehan, R. Marsland, A. Gorgulho, A. De Salles, E. C. Miguel, S. A. Rasmussen, S. A. Sheth
Summary: Obsessive-compulsive disorder (OCD) affects 2-3% of the population. Gamma knife capsulotomy (GKC) is an effective treatment option for refractory OCD. Lesions occurring in the ventral and posterior areas of the anterior limb of the internal capsule (ALIC) are associated with the greatest reduction in OCD symptoms.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Bryan Zheng, Hael Abdulrazeq, Belinda Shao, David D. Liu, Owen Leary, Peter M. Lauro, Luca Bartolini, Andrew S. Blum, Wael F. Asaad
Summary: In patients with treatment-refractory temporal lobe epilepsy, a second LITT procedure may be effective in achieving improved seizure outcomes. This study investigated the feasibility and potential efficacy of repeat LITT amygdalohippocampotomy by quantifying changes to targeted mesial temporal lobe structures and seizure outcomes.
EPILEPSY & BEHAVIOR
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)