Article
Dermatology
Jack Lee, Vernon J. Forrester, Wendy M. Novicoff, Darren J. Guffey, Mark A. Russell
Summary: In a retrospective analysis of SCCs and basal cell carcinomas treated with Mohs surgery at a single institution, the study identified an association between surgical delays and tumor growth for higher-grade SCCs, suggesting potential clinical significance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Dermatology
Stephanie Clements, Amor Khachemoune
Summary: The incidence of NMSC is increasing in the US, with a significant proportion being upstaged during surgery. Biopsy sampling error and variability in reporting contribute to discrepancies. More comprehensive treatment modalities may be necessary for high-risk tumors.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Oncology
Peter R. Jermain, Tyler W. Iorizzo, Mary Maloney, Bassel Mahmoud, Anna N. Yaroslavsky
Summary: This study developed and tested a novel handheld optical polarization imaging (OPI) system for the rapid and noninvasive detection of basal cell carcinoma (BCC) margins. The results showed that OPI could be a valuable tool for optimizing surgical treatment of skin cancer.
Article
Dermatology
Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Chaoran Hu, Rong Wu, Desiree Ratner, Hao Feng, Jonathan Ungar, Jonathan Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Summary: A study conducted in the Icelandic population demonstrated that statin exposure is associated with an increased risk of SCC, but not BCC. Additionally, the association of statins with SCC was significant in patients over 60, but not in those under 60.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Review
Dermatology
Tomasz Krzysztofiak, Grazyna Kaminska-Winciorek, Aleksandra Pilsniak, Piotr Wojcieszek
Summary: This study reviewed English medical full-text papers to evaluate the efficacy and safety of high dose rate (HDR) brachytherapy (BT) as a treatment option for nonmelanoma skin cancers (NMSCs). The results showed that HDR BT has good local control and cosmetic outcomes. Compared to other treatment methods, HDR BT is considered a potentially noninferior treatment option.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Kevin K. Veverka, Erik J. Stratman
Summary: This retrospective study examined the 5-year recurrence rate of EDC for SCCIS and found that EDC can achieve a high 5-year cure rate across various anatomical sites. However, counseling patients should take into consideration the specific anatomical location when assessing the overall cure rate.
DERMATOLOGIC SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Tuba M. Ansary, M. D. Razib Hossain, Mayumi Komine, Mamitaro Ohtsuki
Summary: Melanoma and squamous cell carcinoma (SCC) are the most common neoplasms in white people, with increasing incidence rates. SCC, the most prevalent malignancy among nonmelanoma skin cancers, is influenced by factors such as extreme ultraviolet radiation, hereditary predisposition, and immunosuppression. SCC tumors have a high tumor mutational burden and expression of immune checkpoints, making them highly responsive to immunotherapies. However, challenges such as resistance to immunotherapy and difficulty in patient selection exist. This review explores the genetic alterations related to SCC, factors contributing to the benefits of immunotherapy, and challenges associated with this treatment regime.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dermatology
Palak V. Patel, Jessica N. Pixley, Hannah S. Dibble, Steven R. Feldman
Summary: This article discusses the cost consideration in the treatment of basal cell carcinoma (BCC) and presents a cost-conscious algorithm based on different scenarios. For superficial BCC smaller than 0.5 cm, curettage and electrodesiccation or cryosurgery are recommended as the first-line treatment. For nodular BCC ranging from 1.1 to 2 cm, curettage and electrodesiccation, cryosurgery, or 5-fluorouracil are prioritized. For giant BCC, superficial radiation therapy is identified as the first-line treatment option.
DERMATOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Ming-Jun Wu, Yu-Chun Chen, Xiao-Li Cui, Qian Yang, Qing-Liang Xue
Summary: This case study demonstrates the positive effect of the PD-1 immunosuppressant tislelizumab in treating basal cell carcinoma.
Article
Dermatology
Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Chaoran Hu, Rong Wu, Desiree Ratner, Jonathan Ungar, Jonathan I. Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Summary: The study found that a cumulative dose of hydrochlorothiazide above 37,500 mg was associated with an increased risk of invasive SCC. Users of hydrochlorothiazide also had a higher risk of SCCis and BCC.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Paulo Muller Ramos, Alessandra Anzai, Bruna Duque-Estrada, Debora Cadore Farias, Daniel Fernandes Melo, Fabiane Mulinari-Brenner, Giselle Martins Pinto, Leonardo Spagnol Abraham, Leopoldo Duailibe Nogueira Santos, Rodrigo Pirmez, Helio Amante Miot
Summary: The study found that high cumulative exposure to HCTZ is associated with an increased risk of keratinocyte carcinoma, particularly invasive SCC. Users of HCTZ also had an increased risk of SCCis and BCC. However, the study also pointed out limitations in adjusting for all potential factors.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Yingjian Huang, Yuqian Wang, Yan Wang, Ning Wang, Qiqi Duan, Shengbang Wang, Meng Liu, Muhammad Ahsan Bilal, Yan Zheng
Summary: This study found that LPCAT1 is upregulated in cSCC and promotes cSCC progression through the EGFR signaling pathway, suggesting that LPCAT1 may be a potential target for cSCC treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
John Q. Lin, Shirley Q. Li, Shufeng Li, Eileen F. Kiamanesh, Sumaira Z. Aasi, Bernice Y. Kwong, Anne Lynn Su Chang
Summary: This study systematically assessed the risk of developing nonmelanoma skin cancers (NMSCs) after ruxolitinib exposure in patients with polycythemia vera (PV) or myelofibrosis (MF). The results showed that ruxolitinib exposure is associated with an increased risk of squamous cell carcinoma (SCC) in PV or MF patients, particularly in non Janus kinase 2-mutated patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
L. Revelles-Penas, D. Revilla-Nebreda, S. Becerril, L. A. Corchete, I Dominguez-Rullan, M. Martins-Lopes, P. Arias-Rodriguez, A. Rodriguez-Guitierrez, L. A. Perez-Romansanta, C. Roman-Curto, J. Canueto
Summary: Microscopic residual disease (MRD) after surgery has an impact on the prognosis of cutaneous squamous cell carcinoma (CSCC), and postoperative radiotherapy (PORT) can improve local control in patients with MRD.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Multidisciplinary Sciences
Pierre Fontanillas, Babak Alipanahi, Nicholas A. Furlotte, Michaela Johnson, Catherine H. Wilson, Steven J. Pitts, Robert Gentleman, Adam Auton
Summary: Researchers developed risk prediction models for the three major types of skin cancer based on genetic and non-genetic risk factors, and introduced a disease score called DRSA for early detection of high-risk individuals. High DRSA scores were associated with earlier disease diagnosis and more severe forms of skin cancer.
NATURE COMMUNICATIONS
(2021)
