Article
Microbiology
Chiaki Tsumori, Shoma Matsuo, Yuta Murai, Kenji Kai
Summary: A study found that strains of Ralstonia solanacearum species complex (RSSC) invade the fungus Fusarium oxysporum by producing extracellular polysaccharide I (EPS I), biofilm, and the signal molecule ralstonins. This invasion process is regulated by the bacterial quorum sensing (QS) system, and is significant for the bacteria-fungus symbiosis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Plant Sciences
Yue Huo, Jong Pyo Kang, Jong Chan Ahn, Yeon Ju Kim, Chun Hong Piao, Dong Uk Yang, Deok Chun Yang
Summary: The study demonstrated that the siderophore-producing Mesorhizobium panacihumi DCY119(T) has the potential to reduce oxidative stress, enhance heavy metal resistance, and be used for bioremediation of heavy metal contamination.
JOURNAL OF GINSENG RESEARCH
(2021)
Review
Microbiology
Kenji Kai
Summary: Ralstonia solanacearum species complex (RSSC) strains are devastating plant pathogens distributed worldwide. The primary cell density-dependent gene expression system in RSSC strains is phc quorum sensing (QS), which regulates the expression of about 30% of all genes. The specificity in generating and receiving its QS signal, but their signaling pathways might not differ significantly. This review discusses the genetic and biochemical factors involved in QS signal input, the regulatory network, and the interactions with soil fungi.
ANNUAL REVIEW OF MICROBIOLOGY
(2023)
Article
Plant Sciences
Anushree Kamath, Arpit Shukla, Dhara Patel
Summary: Quorum Sensing (QS) is a communication system among microorganisms that regulates important functions such as virulence factor production, sporulation, conjugation, infections and invasions, colonization, biofilm formation, and antibiotic resistance. Quorum Quenching (QQ) is a process that reduces virulence factors and inhibits quorum-sensing molecules. Modulating quorum quenching enzymes and quorum sensing molecules can determine the Biocontrol potential of Plant growth promoting rhizobacteria (PGPR) strain, making it a sustainable agronomic approach to combat disease-causing agents and promote crop recovery.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2023)
Article
Food Science & Technology
Fangchao Cui, Qianqian Wang, Jiayi Liu, Dangfeng Wang, Jianrong Li, Tingting Li
Summary: This study aimed to explore the effects of siderophore synthetase gene deletion on the growth, quorum sensing (QS), and spoilage potential of Pseudomonas fragi (P. fragi). The results showed that the deletion of the siderophore biosynthesis gene significantly slowed down the growth rate of P. fragi. The mutant strain exhibited reduced apoptosis rate, biofilm formation, extracellular protease expression, and signal molecule production compared with the wild-type strain, indicating a reduced spoilage ability.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Review
Microbiology
Rohit Patel, Mansi Soni, Bilv Soyantar, Suruchi Shivangi, Swati Sutariya, Meenu Saraf, Dweipayan Goswami
Summary: The indiscriminate use of antibiotics has led to the emergence of drug-resistant strains. Many infectious diseases are caused by microbes that can communicate through quorum sensing (QS), and interfering with QS can effectively control their pathogenicity. Inhibition of QS has become a promising approach for developing new drugs, and various quorum sensing inhibitors (QSIs) have been identified. This review provides an overview of the QS mechanism, QS inhibition, and compounds with anti-QS potential, as well as the possibility of quorum sensing resistance.
ARCHIVES OF MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Sudipta Paul Bhattacharya, Snigdha Karmakar, Kusumita Acharya, Arijit Bhattacharya
Summary: The development of biofilms is a protective strategy used by bacterial pathogens against the immune response and antimicrobial treatments. Quorum sensing, which alters gene expression profiles, has been identified as a key regulator of biofilm dynamics. With the rapid emergence of antimicrobial resistance, it is urgent to find alternative interventions to control biofilm infections. Exploring phytochemical products has shown promise in inhibiting quorum sensing and preventing biofilm formation. Recent studies have focused on triterpenoids and their derivatives, which have been found to disrupt quorum sensing and impair biofilm formation against bacterial pathogens.
Article
Biotechnology & Applied Microbiology
Jinli Yan, Peng Li, Xiaoqing Wang, Minya Zhu, Hongyu Shi, Guohui Yu, Xuemei Chen, Huishan Wang, Xiaofan Zhou, Lisheng Liao, Lianhui Zhang
Summary: In this study, a new functional QS system (RasI/R) was identified and characterized in R. solanacearum strain EP1, which plays an important role in regulating bacterial virulence. This QS system produces and responds to the QS signal 3-OH-C12-HSL and regulates critical bacterial abilities in survival and infection. These findings provide new insight into the complicated QS regulatory networks of R. solanacearum, and offer potential targets for controlling and preventing bacterial wilt diseases.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Environmental Sciences
Changfei He, Li Zheng, Wei Gao, Jinfeng Ding, Chengxuan Li, Xiyuan Xu, Bin Han, Qian Li, Shuai Wang
Summary: This study investigated the distribution and functional diversity of AHL producers in the root environment of S. glauca and P. australis in coastal wetlands. The research found variations in AHL profiles between the rhizosphere soil and root tissues, suggesting different ecological roles for AHL producers in these two environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lujun Yin, Yingjie Wang, Shiliang Xiang, Kaizhong Xu, Bo Wang, Ai-Qun Jia
Summary: In this study, it was found that tyramine could inhibit the production of virulence factors in Burkholderia cenocepacia by blocking the quorum sensing systems. It was also shown to have low toxicity and potential as a combination therapy with traditional antibiotics.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Jun Liu, Si-Yu Zhao, Jia-Yi Hu, Qiu-Xian Chen, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai-Bo Zhou, Jun-Xia Zheng, Ping-Hua Sun
Summary: This study reports a dual-acting antibiofilm strategy by inhibiting both the bacterial quorum sensing system and the iron uptake system in Pseudomonas aeruginosa. Compound 4t was identified as a potent biofilm inhibitor and also enhanced the antibacterial effects of ciprofloxacin and tobramycin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Aditi Vashistha, Nikhil Sharma, Yerramsetti Nanaji, Deepak Kumar, Gurpal Singh, Ravi P. Barnwal, Ashok Kumar Yadav
Summary: The overuse and inappropriate use of antibiotics has led to the development of drug resistant bacterial strains. Biofilm, a complex microorganism aggregation, plays a crucial role in infectious diseases. Efforts to disrupt biofilms have identified molecules that can inhibit quorum sensing, offering potential treatments for bacterial infections with lower dosages of medications.
BIOORGANIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Shang Wang, Chen Zhao, Bin Xue, Chenyu Li, Xi Zhang, Xiaobo Yang, Yan Li, Yanping Yang, Zhiqiang Shen, Jingfeng Wang, Zhigang Qiu
Summary: This study showed that nanoalumina treatment triggered the formation of persister cells, with the involvement of reactive oxygen species and toxin-antitoxin system. Only the gene hipB was associated with persister formation, indicating the involvement of other mechanisms. Transcriptome sequencing identified 73 differentially expressed genes, with five closely related to quorum sensing and the expression of lrsF and qseB being a novel pathway for persister formation. This research provides insights into bacterial persistence and microbial behavior under exposure to nanomaterials.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Qingying Fan, Jing Zuo, Haikun Wang, Daniel Grenier, Li Yi, Yang Wang
Summary: Quorum sensing (QS) is an important part of cell/cell communication, especially in bacteria. Bacteria use QS to perceive and regulate gene expression to adapt to their complex habitats, including controlling the expression of virulence factors and antibiotic resistance. Targeting QS has proven to be a promising alternative strategy for controlling infections, especially in zoonotic bacteria.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Green & Sustainable Science & Technology
Hema Chandran, Mukesh Meena, Prashant Swapnil
Summary: Plant growth-promoting rhizobacteria (PGPR) offer an eco-friendly alternative to synthetic agrochemicals by enhancing plant stress tolerance through mechanisms such as the release of phytohormones, nitrogen fixation, and production of antioxidant enzymes. PGPR strains genetically engineered can alleviate abiotic stress and improve crop productivity, highlighting their significant roles in sustainable agriculture.
