Journal
BIOLOGICAL CHEMISTRY
Volume 393, Issue 1-2, Pages 101-106Publisher
WALTER DE GRUYTER & CO
DOI: 10.1515/BC-2011-213
Keywords
inflammation; innate immunity; signaling
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Funding
- Deutsche Forschungsgemeinschaft [DFG560/5-1, SFB832 TP19]
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The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-kappa B-dependent release of TNF-alpha/IFN-gamma. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.
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