Journal
BIOLOGICAL CHEMISTRY
Volume 391, Issue 4, Pages 311-320Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2010.024
Keywords
activation cascade; kallikrein; kallikrein-related peptidase (KLK); plasmin; thrombogenesis; thrombolysis; thrombostasis
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Funding
- NINDS NIH HHS [R15 NS057771-01, R15 NS057771, R01 NS052741-03, R01 NS052741] Funding Source: Medline
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A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
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