Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 36, Issue 1, Pages 125-130Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b12-00760
Keywords
neuropathic pain; intrathecal; combination drug therapy; ketamine; pregabalin; mouse
Categories
Funding
- Chungnam National University [2009-0971]
Ask authors/readers for more resources
Peripheral or central nerve injury often leads to neuropathic pain. Although ketamine and pregabalin are first line options for the treatment of neuropathic pain, their clinical application is limited due to side effects such as sedation, dizziness and somnolence. We designed this study to determine whether the intrathecal (i.t.) co-treatment with ketamine and pregabalin at sub-effective low doses would elicit a sufficient pain relief without producing side effect in a neuropathic pain mouse model. At day 7 after chronic constriction injury (CCI) of sciatic nerve, dose dependent effects of i.t. ketamine (3, 10, 30, 100 mu g) or i.t. pregabalin (10, 30, 100 mu g) on mechanical allodynia and thermal hyperalgesia were measured. For combination treatment, 3 or 10 mu g of ketamine and 30 mu g of pregabalin were selected because these doses of drugs were not effective on neuropathic pain. Interestingly, combined i.t. treatment groups (ketamine 3 mu g+pregabalin 30 mu g and ketamine 10 mu g+pregabalin 30 mu g) produced strong analgesia on neuropathic pain although these doses of ketamine and pregabalin alone are not effective. Moreover, rota rod test revealed that normal motor function was not affected by combined treatment while i.t. ketamine at doses above 10 mu g showed a significant motor dysfunction. Results of this study suggested that i.t. co-treatment with ketamine and pregabalin at sub-effect low doses may be a useful therapeutic method for the treatment of neuropathic pain patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available