Article
Biophysics
Naghmeh Shahraki, Amin Mehrabian, Shahrazad Amiri-Darban, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari
Summary: The study demonstrated that Lp31-modified Caelyx exhibited enhanced cytotoxicity and cellular uptake in C26 cell line compared to Caelyx. In BALB/c mice bearing C-26 murine carcinoma, Lp31-modified Caelyx groups showed significantly higher doxorubicin concentration at tumor tissue. Furthermore, Lp31-modified Caelyx at the dose of 10 mg/kg resulted in significant tumor growth inhibition and enhanced survival time compared to Caelyx.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Maryam Ebrahimi Nik, Mahmoud Reza Jaafari, Mohammad Mashreghi, Sara Nikoofal-Sahlabadi, Mohamadreza Amin, Hamid Reza Sadeghnia, Mehrdad Iranshahi, Jamshid Gholizadeh Navashenaq, Bizhan Malaekeh-Nikouei
Summary: The study developed new liposomal formulations to enhance the anti-cancer therapeutic application of Galbanic acid, and demonstrated that RGD peptide decoration could improve targeted delivery to tumor vasculature. The results showed that the targeted liposomes could enhance receptor-mediated endocytosis both in vitro and in vivo, leading to increased accumulation in colon tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ying Wang, Mimi Guo, Dingmei Lin, Dajun Liang, Ling Zhao, Ruizhi Zhao, Yan Wang
Summary: The study successfully prepared EXO-DTX with a particle size of 149.5 nm, showing significantly greater cytotoxicity than DTX monomers and better targeting and cellular uptake both in vitro and in vivo. The potential of tumor cell-derived exosomes as a drug delivery system targeting the parent cancer was also explored, suggesting exosomes might be used as a potential antitumor drug delivery system (DDS).
Article
Oncology
Diana Bradford, Erin Larkins, Sirisha L. Mushti, Lisa Rodriguez, Amy M. Skinner, Whitney S. Helms, Lauren S. L. Price, Jeanne Fourie Zirkelbach, Yangbing Li, Jiang Liu, Rosane Charlab, Francisca Reyes Turcu, Dun Liang, Soma Ghosh, Donna Roscoe, Reena Philip, Autumn Zack-Taylor, Shenghui Tang, Paul G. Kluetz, Julia A. Beaver, Richard Pazdur, Marc R. Theoret, Harpreet Singh
Summary: The FDA granted accelerated approval to selpercatinib on May 8, 2020 for patients with metastatic RET fusion-positive non-small cell lung cancer, RET-mutant medullary thyroid cancer, and RET fusion-positive thyroid cancer. The approval was based on significant effects on overall response rate and prolonged duration of responses observed in clinical trials across multiple indications. The product label includes warnings for various adverse reactions such as hepatotoxicity, hypertension, and embryo-fetal toxicity.
CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Maryam Iman, Seyedeh Alia Moosavian, Parvin Zamani, Mahmoud Reza Jaafari
Summary: Active targeting of the tumor microenvironment using nucleolin-targeted PEGylated liposomal doxorubicin (AS-PLD) has shown higher therapeutic efficacy compared to traditional liposomal doxorubicin (PLD). In vitro studies demonstrated that AS-PLD exhibited increased cytotoxicity and cellular uptake in cancer cells. Additionally, competition assays confirmed the specificity of AS-PLD in targeting tumor cells. Furthermore, in vivo analysis showed higher accumulation of AS-PLD in the tumor after 72 hours post-injection, indicating its potential as an active-targeted formulation for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Niloufar Rahiman, Parvin Zamani, Leila Arabi, Seyedeh Hoda Alavizadeh, Aminreza Nikpoor, Mohammad Mashreghi, Ali Badiee, Mahmoud Reza Jaafari
Summary: The study explores the use of liposomal formulations of Glatiramer acetate (GA) to overcome the frequent administration rate required for MS therapy. The results show that liposomal GA has higher efficacy in a murine model of MS, suggesting its potential as a reliable nanomedicine-based platform for MS treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
M. Yasmin Begum, Riyaz Ali M. Osmani, Ali Alqahtani, Mohammed Ghazwani, Umme Hani, Hissana Ather, Akhtar Atiya, Mohamed Rahamathulla, Ayesha Siddiqua
Summary: This study developed stealth liposomes of CLB to reduce its side effects and increase drug accumulation in inflammation sites. The results showed that stealth liposomes significantly reduced inflammation and had extended drug bioavailability with lower toxicity.
Article
Chemistry, Medicinal
Song Ding, Christopher L. Hackett, Fang Liu, Ryan G. Hackett, Ulrich Bierbach
Summary: Liposomal formulations of a highly cytotoxic platinum-acridine agent have been developed and demonstrated effective cellular uptake and tumor inhibition in cultured lung cancer cells. These findings validate the utility of platinum-acridine agents in treating aggressive, chemoresistant forms of cancer.
Article
Chemistry, Multidisciplinary
Paula Melania Pasca, Florina Miere Miere (Groza), Angela Antonescu, Luminita Fritea, Florin Banica, Simona Ioana Vicas, Vasile Laslo, Dana Carmen Zaha, Simona Cavalu
Summary: A novel liposomal formulation based on azelaic acid was developed, showing good biocompatibility, bioavailability, antimicrobial, antigenotoxic, and anti-inflammatory properties. The formulation exhibited excellent antibacterial activity and accelerated wound healing effect, while protecting cells from DNA damage.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Applied
Jun Wang, Justin Liu, Dao-Qiang Lu, Lijing Chen, Rujia Yang, Dahai Liu, Bin Zhang
Summary: In this study, diselenide-crosslinked nanoparticles were successfully fabricated for doxorubicin delivery. The nanoparticles exhibited desirable morphology and size distribution, and the starting material used improved biocompatibility and physiological stability. The high drug encapsulation efficiency of the nanoparticles was achieved through electrostatic interactions between doxorubicin and the material. In vitro and in vivo experiments demonstrated that the doxorubicin-loaded diselenide-crosslinked nanoparticles had higher drug accumulation and enhanced growth inhibition compared to the control samples.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Saurabh Shah, Paras Famta, Valencia Fernandes, Deepkumar Bagasariya, Kondasingh Charankumar, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava
Summary: The study shows that the liposomal thermogel system loaded with Niclosamide can effectively enhance the uptake and apoptosis of melanoma cells, making it a potential alternative therapy for melanoma management.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Vaishali Y. Londhe, Sushmita Sharma
Summary: This study aimed to develop a topically effective sustained release ophthalmic liposomal gel containing Methazolamide. By optimizing the liposomal formulation and gel composition, the researchers successfully achieved a significant reduction in intraocular pressure.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mine Diril, Kemal Volkan Ozdokur, Yeliz Yildirim, H. Yesim Karasulu
Summary: In this study, a liver-targeting ligand was conjugated with polyethylene glycol and incorporated into liposomes to improve the delivery of the chemotherapy drug for hepatocellular carcinoma (HCC). The optimized formulation showed high drug encapsulation capacity and demonstrated superior toxicity against HCC cells compared to the commercial formulation, while being less toxic to non-cancerous cells. It also exhibited enhanced tumor penetration and antitumor efficacy in a mouse liver cancer model.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Elisa Landucci, Francesca Bonomolo, Chiara De Stefani, Costanza Mazzantini, Domenico Edoardo Pellegrini-Giampietro, Anna Rita Bilia, Maria Camilla Bergonzi
Summary: Two liposomal formulations, one of which is coated with hyaluronic acid, have been developed to enhance the solubility of Thymoquinone (TQ) and increase its absorption at the cellular level, especially in the nucleus. These formulations not only decrease TQ toxicity observed at high doses in cells, but also result in a gradual and prolonged release of TQ in both coated and uncoated liposomes.
Article
Nanoscience & Nanotechnology
Jing Chen, Yuan Lin, Min Wu, Chuangnan Li, Yimin Zhang, Dongpeng Chen, Yi Cheng
Summary: This research optimized the enzymatic synthesis of mannosylated ligands and prepared mannosylated liposomes, showing promising bioactivity for liver targeting. The characterization of mannosylated liposomes demonstrated their safety and efficacy as a drug delivery system for hepatic diseases. HepG2 cells exhibited higher cellular uptake of mannosylated liposomes, indicating their potential therapeutic value.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
