Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 33, Issue 3, Pages 415-420Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.415
Keywords
gambogenic acid; anticancer effect; apoptosis; cell cycle
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Although anticancer effect of gambogic acid (CA) and its potential mechanisms were well documented in past decades, limited information is available oil the anticancer effect of gambogenic acid (GNA), another major active component of Gamboge. Here we performed a study to determine whether GNA possesses anticancer effect and find its potential mechanisms. The results suggested that GNA significantly inhibited the proliferation of several tumour Cell lines in vivo and in vivo. Treatment with GNA dose and time dependently induced A549 cells apoptosis, arrested the cells to G0/G1 phase in vitro and down-regulated the expression of cyclin D1 and cyclooxygenase (COX)-2 in mRNA level. In addition, anticancer effect was further demonstrated by applying xenografts in nude mice coupled with the characteristic of apoptosis in the GNA treated group. Taken together, these observations might suggest that GNA inhibits tumor cell proliferation via apoptosis-induction and cell cycle arrest.
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