Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 32, Issue 8, Pages 1411-1416Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.32.1411
Keywords
diabetes mellitus; oxidative stress; angiotensin receptor blocker; heart; kidney
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Promotion and Mutual Aid Corporation for Private Schools, Japan
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The important role of renin-angiotensin-aldosterone system blockade in the treatment of diabetes-induced cardiomyopathy and nephropathy has been clearly established. The present stud), examined the effect of angiotensin 11 type I receptor blocker (ARB) losartan on oxidative stress and cardio-renal function in streptozotocin (STZ)-induced diabetic rats. Losartan treatment resulted in improvement of myocardial function and suppressed cardiac and renal fibrosis compared with the diabetic group. Losartan treatment also down-regulated transforming growth factor-beta 1 expression and attenuated the increased expression levels of p22(phox) and Nox4. Blood urea nitrogen (BUN) and urinary protein levels were increased significantly in the diabetic group. Losartan treatment significantly reduced proteinuria but not BUN level. Moreover, the elevated level of malondialdehyde in both heart and kidney were significantly reduced in the losartan-treated group compared with the diabetic group. These results provided evidence that oxidative stress plays a major role in diabetic rats induced by STZ, and treatment with the ARB might be beneficial for preventing the development and progression of diabetic disease.
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