Article
Medicine, Research & Experimental
Jiaqi Li, Yuyao Sun, Chao Xue, Xiaoxiao Yang, Yajun Duan, Dan Zhao, Jihong Han
Summary: This study explores the effect of Nogo-B on white adipogenesis and its underlying molecular mechanisms. The findings demonstrate that Nogo-B deficiency inhibits white adipogenesis through the AKT2/GSK313/13-catenin pathway and promotes the generation of brown/beige adipocytes. Additionally, Nogo-B deficiency reduces inflammatory cytokine levels caused by adipogenesis. Overall, blocking Nogo-B expression may be a potential strategy to suppress white adipogenesis.
Review
Cell Biology
Linjing Yan, Liang Guo
Summary: Exercise can regulate the differentiation of white adipocytes through various mechanisms, helping improve metabolism and combat obesity. A comprehensive understanding of the role and mechanism of exercise in white adipocyte differentiation would provide new insights and facilitate the application of exercise-based strategies against obesity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Min Chen, Soochi Kim, Liang Li, Sourav Chattopadhyay, Thomas A. Rando, Brian J. Feldman
Summary: Through single-cell RNA sequencing, a population of CD31- CD45- cells with a specific expression profile is discovered in the stromal vascular fraction of adipose tissue. This population is placed on an epistatic pathway upstream of preadipocytes and functional properties with broad implications, including physiological mechanisms regulating adipogenesis, are revealed.
Article
Physiology
Peng-Peng Zhang, Qiu Han, Ming-Xuan Sheng, Chun-Yu Du, Ya-Ling Wang, Xiao-Fang Cheng, Hai-Xia Xu, Cen-Cen Li, Yong-Jie Xu
Summary: The study identified a large number of circRNAs expressed in white adipogenesis, with differentially expressed circRNAs potentially playing important roles in regulating adipogenesis and many circRNAs potentially facilitating regulatory functions by acting as miRNA sponges.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Muhammad Rahil Aslam, Yoshiko Igarashi, Ayumi Nishimura, Yoshiyuki Watanabe, Takahide Kuwano, Jianhui Liu, Hiroyuki Miwa, Takumi Era, Koichi Ikuta, Johji Imura, Kunimasa Yagi, Takashi Nakagawa, Shiho Fujisaka, Kazuyuki Tobe
Summary: The expansion of adipose tissue during obesity through the recruitment of newly generated adipocytes is metabolically healthy, particularly in the gonadal white adipose tissue of male mice receiving a high-fat diet. Contrary to previous findings, the inguinal white adipose tissue of male mice also shows a high potential for proliferation and differentiation of adipocyte progenitors, leading to hyperplasia in response to high-fat diet feeding.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Jasmine A. Burrell, Jacqueline M. Stephens
Summary: KAT8 is essential for adipocyte differentiation, with its loss inhibiting the formation of adipocytes in the early stages. However, its absence does not significantly impact later stages of adipocyte differentiation. Further studies are needed to determine the specific functions and regulation of KAT8 in adipose tissue.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Endocrinology & Metabolism
Tammy Ying, Rebecca A. Simmons
Summary: Understanding the development of adipocyte precursors is crucial for preventing obesity-related diseases. Recent studies using new techniques to analyze adipocyte precursors have revealed insights into their lineages and regulatory mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Dandan Wu, Dianna Spilca, Que Le, Xin Yang, Katelyn Alvarez, William Curtis Hines, Xuexian O. Yang, Meilian Liu
Summary: The lack of COX-2 in adipocytes promotes white adipose tissue development and increases the size and number of adipocytes, leading to obesity and insulin resistance. Treatment with PGE2 can reverse the increased size and number of adipocytes caused by COX-2 knockout.
Article
Biochemistry & Molecular Biology
Akiko Katano-Toki, Satoshi Yoshino, Yasuyo Nakajima, Takuya Tomaru, Ayaka Nishikido, Emi Ishida, Kazuhiko Horiguchi, Tsugumichi Saito, Atsushi Ozawa, Tetsurou Satoh, Masanobu Yamada
Summary: HELZ2 deficiency leads to resistance to obesity and NAFFL/NASH in mice, and the association of tyrosine-phosphorylated HELZ2 with SFPQ protein affects the expression levels of key factors for adipocyte differentiation, thus impacting the process of cell differentiation and maturation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Wenjing Liu, Dahui Li, Handi Cao, Haoyun Li, Yu Wang
Summary: Adipose tissue is an essential organ in the body, involved in energy metabolism and immune regulation. White adipose tissue expansion and inflammation are associated with obesity, but the primary event triggering this process remains unclear.
BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Milica Vranic, Fozia Ahmed, Susanne Hetty, Assel Sarsenbayeva, Vitor Ferreira, Giovanni Fanni, Angela M. Valverde, Jan W. Eriksson, Maria J. Pereira
Summary: We investigated the effects of second-generation antipsychotics (SGAs) on adipocyte differentiation and metabolism and found that aripiprazole (ARI) can impair adipocyte glucose uptake and increase fatty acid oxidation gene expression, while olanzapine (OLA) can increase leptin gene expression. These findings have important implications for understanding the metabolic effects of antipsychotic drugs and suggest that different SGAs may have different mechanisms of action.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Caputo, Van Du T. Tran, Nasim Bararpour, Carine Winkler, Gabriela Aguileta, Khanh Bao Trang, Greta M. P. Attianese, Anne Wilson, Aurelien Thomas, Marco Pagni, Nicolas Guex, Beatrice Desvergne, Federica Gilardi
Summary: Chronic inflammation in metabolic organs, such as white adipose tissue, is a major factor in obesity-related health issues. High-fat diets trigger different responses in visceral and subcutaneous adipose tissue, with the former experiencing limited expansion due to antiadipogenic signals and the latter allowing storage of excessive fatty acids. Differential regulation of adipocyte number and differentiation in response to obesogenic stimuli plays a crucial role in the susceptibility to obesity-related inflammation between visceral and subcutaneous adipose tissue depots.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Chemistry, Medicinal
Dharmani Devi Murugan, Dharvind Balan, Pooi-Fong Wong
Summary: Obesity is a serious public health issue, and in addition to lifestyle changes and dietary modifications, pharmacotherapy is considered as an alternative strategy for treatment. Bioactive phytochemicals are being explored as a valuable source for new antiobesity agents, but further research is needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Xinhao Ma, Xinran Yang, Dianqi Zhang, Wenzhen Zhang, Xiaoyu Wang, Kuncheng Xie, Jie He, Chugang Mei, Linsen Zan
Summary: This study conducted a comprehensive analysis of long non-coding RNAs (lncRNAs) in bovine intramuscular adipocytes during adipogenesis, identifying a total of 7035 lncRNAs, including 3396 novel lncRNAs. One particular lncRNA, BIANCR, was found to play a crucial regulatory role in adipogenesis through the ERK1/2 signaling pathway.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Medical Laboratory Technology
Tamara Camino, Nerea Lago-Baameiro, Susana Belen Bravo, Alberto Molares-Vila, Aurelio Sueiro, Ivan Couto, Javier Baltar, Eelipe F. Casanueva, Maria Pardo
Summary: This study characterized the protein cargo of extracellular vesicles (EVs) released by adipose tissue (AT) in obese individuals using mass spectrometry analysis. The results revealed that EVs shed by visceral adipose tissue (VAT) in obese individuals contained more inflammation-related proteins compared to those shed by subcutaneous adipose tissue (SAT). Additionally, specific proteins identified in the EVs were associated with disease status and could serve as candidate biomarkers. These findings provide important insights into the mechanisms underlying obesity and related metabolic disorders.
TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Junji Moriya, Rui Chen, Jun-ichi Yamakawa, Kenroh Sasaki, Yasuhito Ishigaki, Takashi Takahashi
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2011)
Article
Integrative & Complementary Medicine
Jun-ichi Yamakawa, Junji Moriya, Takashi Takahashi, Atsushi Ishige, Yoshiharu Motoo, Fumihiko Yoshizaki, Tsugiyasu Kanda
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2010)
Article
Integrative & Complementary Medicine
Zhu Shijie, Junji Moriya, Jun'ichi Yamakawa, Rui Chen, Takashi Takahashi, Hiroyuki Sumino, Takeshi Nakahashi, Kunimitsu Iwai, Shigeto Morimoto, Nobuo Yamaguchi, Tsugiyasu Kanda
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2010)
Review
Integrative & Complementary Medicine
Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Tsugiyasu Kanda
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2010)
Article
Immunology
Rui Chen, Junji Moriya, Xianwen Luo, Jun-ichi Yamakawa, Takashi Takahashi, Kenroh Sasaki, Fumihiko Yoshizaki
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2009)
Article
Cardiac & Cardiovascular Systems
Rui Chen, Fengxia Liang, Shigeto Morimoto, Qian Li, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Kunimitsu Iwai, Tsugiyasu Kanda
INTERNATIONAL HEART JOURNAL
(2010)
Review
Cardiac & Cardiovascular Systems
Rui Chen, Fengxia Liang, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Lin Shen, Tsugiyasu Kanda
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2008)
Review
Medicine, Research & Experimental
Q. Li, R. Chen, J. Moriya, J. Yamakawa, H. Sumino, T. Kanda, T. Takahashi
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2008)
Review
Medicine, Research & Experimental
R. Chen, F. X. Liang, J. Moriya, J. Yamakawa, H. Sumino, T. Kanda, T. Takahashi
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2008)
Article
Biochemistry & Molecular Biology
Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kanda
NEUROCHEMICAL RESEARCH
(2008)
Article
Cardiac & Cardiovascular Systems
Seiichiro Saegusa, Yu Fei, Takashi Takahashi, Hiroyuki Sumino, Junji Moriya, Ken Kawaura, Jun-ichi Yamakawa, Tohoru Itoh, Shigeto Morimoto, Takeshi Nakahashi, Kunimitsu Iwai, Masayuki Matsumoto, Tsugiyasu Kanda
CARDIOVASCULAR DRUGS AND THERAPY
(2007)
Article
Medicine, Research & Experimental
K. Kusaka, T. Itoh, K. Kawaura, J. Moriya, J. Yamakawa, T. Takahashi, M. Oguchi, H. Tonami, I. Yamamoto, T. Kanda
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2006)
Article
Medicine, Research & Experimental
F. Yu, T. Takahashi, J. Moriya, K. Kawaura, J. Yamakawa, K. Kusaka, T. Itoh, H. Sumino, S. Morimoto, T. Kanda
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2006)
Review
Medicine, Research & Experimental
R. Yu, T. Takahashi, J. Moriya, K. Kawaura, J. Yamakawa, K. Kusaka, T. Itoh, S. Morimoto, N. Yamaguchi, T. Kanda
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2006)