Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH)

Calcium-sensing receptor 20 years later

(2014) Tariq I. Alfadda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mutational Analysis of the Adaptor Protein 2 Sigma Subunit (AP2S1) Gene: Search for Autosomal Dominant Hypocalcemia Type 3 (ADH3)

(2014) Angela Rogers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Autosomal Dominant Hypoparathyroidism Caused by Germline Mutation inGNA11: Phenotypic and Molecular Characterization

(2014) Dong Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Analysis ofAP2S1, a Calcium-Sensing Receptor Regulator, in Familial and Sporadic Isolated Hypoparathyroidism

(2014) Anne-Sophie Lambert et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Phase 2, Randomized, Placebo-Controlled, Dose-Ranging Study of the Calcium-Sensing Receptor Antagonist MK-5442 in the Treatment of Postmenopausal Women With Osteoporosis

(2014) Johan Halse et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A semimechanistic model of the time-course of release of PTH into plasma following administration of the calcilytic JTT-305/MK-5442 in humans

(2013) Antonio Cabal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss-of-Function and Gain-of-Function Mutations of Calcium-Sensing Receptor: Functional Analysis and the Effect of Allosteric Modulators NPS R-568 and NPS 2143

(2013) Akie Nakamura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional Activities of Mutant Calcium-Sensing Receptors Determine Clinical Presentations in Patients With Autosomal Dominant Hypocalcemia

(2013) Yuka Kinoshita et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia

(2013) M. Andrew Nesbit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study

(2013) Michael Mannstadt et al.   Lancet Diabetes & Endocrinology

Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites

(2012) F. M. Hannan et al.   HUMAN MOLECULAR GENETICS

Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure

(2012) Rachel I Gafni et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CASR gene activating mutations in two families with autosomal dominant hypocalcemia

(2012) Vito Guarnieri et al.   MOLECULAR GENETICS AND METABOLISM

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3

(2012) M Andrew Nesbit et al.   NATURE GENETICS

Structure and formation of the twisted plywood pattern of collagen fibrils in rat lamellar bone

(2012) Tsuneyuki Yamamoto et al.   Microscopy

Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey

(2011) Friedhelm Raue et al.   CLINICAL ENDOCRINOLOGY

The Calcium-Sensing Receptor: A Molecular Perspective

(2011) Aaron L. Magno et al.   ENDOCRINE REVIEWS

Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor

(2011) Anna E. Davey et al.   ENDOCRINOLOGY

JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats

(2011) Shuichi Kimura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: A randomized, placebo-controlled study

(2011) Tanja Sikjaer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism

(2011) Mishaela R Rubin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autosomal Dominant Hypoparathyroidism with Severe Hypomagnesemia and Hypocalcemia, Successfully Treated with Recombinant PTH and Continuous Subcutaneous Magnesium Infusion

(2011) S. Sanda et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Long-Term Treatment of 12 Children with Chronic Hypoparathyroidism: A Randomized Trial Comparing Synthetic Human Parathyroid Hormone 1-34versusCalcitriol and Calcium

(2010) Karen K. Winer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Low bone turnover and increase of bone mineral density in a premenopausal woman with postoperative hypoparathyroidism and thyroxine suppressive therapy

(2010) K. Amrein et al.   OSTEOPOROSIS INTERNATIONAL

Therapy of hypoparathyroidism with intact parathyroid hormone

(2010) M. R. Rubin et al.   OSTEOPOROSIS INTERNATIONAL

Discovery of a Potent and Short−Acting Oral Calcilytic with a Pulsatile Secretion of Parathyroid Hormone

(2010) Yuko Shinagawa et al.   ACS Medicinal Chemistry Letters

An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation

(2009) Sanjay Kumar et al.   BONE

Three dimensional cancellous bone structure in hypoparathyroidism

(2009) Mishaela R. Rubin et al.   BONE

Agonists and Allosteric Modulators of the Calcium-Sensing Receptor and Their Therapeutic Applications

(2009) Z. Saidak et al.   MOLECULAR PHARMACOLOGY

Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism

(2008) Mishaela R Rubin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PTH(1-34) Replacement Therapy in a Child With Hypoparathyroidism Caused by a Sporadic Calcium Receptor Mutation

(2008) Todd A Theman et al.   JOURNAL OF BONE AND MINERAL RESEARCH