Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: This article reviews the recent advances in understanding the molecular mechanism of skeletal-neural interactions in bone homeostasis, with a focus on the functions of axon guidance molecules in the establishment and maintenance of the skeletal system.
Review
Physiology
Scott Epsley, Samuel Tadros, Alexander Farid, Daniel Kargilis, Sameer Mehta, Chamith S. Rajapakse
Summary: Bone remodeling is a continual process involving osteoblasts and osteoclasts, where inflammation plays a crucial role in skewing the process towards resorption. Inflammatory mediators interact with bone cells to alter the expression of regulatory factors, leading to various bone-related pathologies. Further research is needed to advance early detection and treatments for bone diseases influenced by inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Review
Biochemistry & Molecular Biology
Tobias M. Ballhause, Shan Jiang, Anke Baranowsky, Sabine Brandt, Peter R. Mertens, Karl-Heinz Frosch, Timur Yorgan, Johannes Keller
Summary: Notch1-4 receptors and their signaling pathways are crucial in cell fate decision by coordinating cell proliferation, differentiation and apoptosis, with differential expression and activation observed in various organs and tissues. In bone, Notch receptors control remodeling and regeneration, with distinct expression and function depending on differentiation stages. The crosstalk between Notch signaling and other pathways in bone turnover, including Wnt/beta-catenin, BMP and RANKL/OPG, is outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: This article reviews recent findings on the molecular mechanisms of bone healing and presents various biological alternatives for treating recalcitrant nonunions, such as using morin, BMP9, and leptin. It also discusses factors that impact bone regeneration, including inhibition of estrogen receptor signaling, smoking-induced inflammatory responses, and delayed fracture healing in diabetic animals due to BMP6 deficiency. The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is highlighted as a promising alternative for treating nonunions that do not respond well to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Tolu Omokehinde, Alec Jotte, Rachelle W. Johnson
Summary: Breast cancer cells in bone marrow can be influenced by a variety of cytokines, some of which may promote tumor growth and metastasis, while others may promote tumor dormancy. Different estrogen receptor statuses of breast cancer cells may respond differently to these signals.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Kok-Yong Chin, Sophia Ogechi Ekeuku, Anne Trias
Summary: Nitrogen-containing bisphosphonates cause BRONJ by inhibiting bone resorption, but GGOH shows promise in managing BRONJ, pending further research and clinical trials for validation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Saravanan Sekaran, Anitha Roy, Lakshmi Thangavelu
Summary: Bone disorders are a global concern, and flavonoids, with their multi-faceted biological activities, play a significant role in maintaining bone health.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Suryaji Patil, Jingxian Jia
Summary: Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wenbo Zhao, Philip Wiedemann, Eva Maria Woelfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Bjoern Busse, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Summary: Col22a1, predominantly expressed in bone, deficiency may result in trabecular osteopenia and increased osteoclast numbers.
Review
Cell Biology
Anna Ruocco, Anna Sirico, Rubina Novelli, Silvia Iannelli, Shane Vontelin Van Breda, Diego Kyburz, Paul Hasler, Andrea Aramini, Pier Giorgio Amendola
Summary: Bone remodeling is a dynamic process dependent on the functions of osteoblasts and osteoclasts. The complement system plays a crucial role in regulating the functions of these cells, particularly in inflammatory states. This review analyzes the role of the C5a-C5aR1 axis in bone physiology and pathophysiology, including its involvement in inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and bone cancer metastasis. Furthermore, pharmacological approaches targeting C5aR1 for the treatment of these conditions are examined. The article highlights the importance of the C5a-C5aR1 axis as a therapeutic target for mediating interactions between the skeletal and immune systems, considering the growing interest in osteoimmunology and the lack of data on its role in bone pathophysiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chen Chen, Ya-Mei Liu, Bin-Lan Fu, Liang-Liang Xu, Bin Wang
Summary: MiRNAs are small regulatory RNA molecules that play important roles in gene expression, with miR-21 in particular having significant effects in orthopedic diseases by influencing osteoblasts, osteoclasts, and the occurrence, development, treatment, and prevention of bone diseases through various mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jun Hou, Hongjie Su, Xiaocong Kuang, Wencong Qin, Kaibing Liu, Kaixiang Pan, Bokai Zhang, Sijie Yang, Shenghui Yang, Xiao Peng, Xinyu Nie, Qikai Hua
Summary: This study identified the research hotspots and development process of osteoblasts-osteoclasts in bone disease using bibliometric and visual methods. It provides a valuable reference for researchers concerned with osteoblasts-osteoclasts in bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Pavan B. Narayanaswamy, Sergey Tkachuk, Hermann Haller, Inna Dumler, Yulia Kiyan
CELL DEATH & DISEASE
(2016)
Article
Oncology
Pavan B. Narayanaswamy, Tapan K. Baral, Hermann Haller, Inna Dumler, Kshitish Acharya, Yulia Kiyan
Article
Cardiac & Cardiovascular Systems
Yulia Kiyan, Sergey Tkachuk, Denise Hilfiker-Kleiner, Hermann Haller, Bianca Fuhrman, Inna Dumler
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2014)
Article
Physiology
Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan
JOURNAL OF VASCULAR RESEARCH
(2013)
Article
Transplantation
Michael S. Balzer, Alexandra Helmke, Martina Ackermann, Janis Casper, Lei Dong, Marcus Hiss, Yulia Kiyan, Song Rong, Kai Timrott, Sibylle von Vietinghoff, Le Wang, Hermann Haller, Nelli Shushakova
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Article
Multidisciplinary Sciences
Pavan B. Narayanaswamy, Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan
Article
Multidisciplinary Sciences
Damilola Dawodu, Margret Patecki, Jan Hegermann, Inna Dumler, Hermann Haller, Yulia Kiyan
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Damilola Dawodu, Margret Patecki, Inna Dumler, Hermann Haller, Yulia Kiyan
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Cardiac & Cardiovascular Systems
Melanie Ricke-Hoch, Martijn F. Hoes, Tobias J. Pfeffer, Stella Schlothauer, Justus Nonhoff, Susanna Haidari, Nils Bomer, Michaela Scherr, Britta Stapel, Elisabeth Stelling, Yulia Kiyan, Christine Falk, Arash Haghikia, Ofer Binah, Zolt Arany, Thomas Thum, Johann Bauersachs, Peter van der Meer, Denise Hilfiker-Kleiner
CARDIOVASCULAR RESEARCH
(2020)
Article
Multidisciplinary Sciences
Yulia Kiyan, Sergey Tkachuk, Kestutis Kurselis, Nelli Shushakova, Klaus Stahl, Damilola Dawodu, Roman Kiyan, Boris Chichkov, Hermann Haller
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Gwenaelle Le Roux, Rafika Jarray, Anne-Cecile Guyot, Serena Pavoni, Narciso Costa, Frederic Theodoro, Ferid Nassor, Alain Pruvost, Nicolas Tournier, Yulia Kiyan, Oliver Langer, Frank Yates, Jean Philippe Deslys, Aloise Mabondzo
SCIENTIFIC REPORTS
(2019)
Letter
Critical Care Medicine
Klaus Stahl, Phillip Alexander Gronski, Yulia Kiyan, Benjamin Seeliger, Anna Bertram, Thorben Pape, Tobias Welte, Marius M. Hoeper, Hermann Haller, Sascha David
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Immunology
Yulia Kiyan, Sergey Tkachuk, Song Rong, Anna Gorrasi, Pia Ragno, Inna Dumler, Hermann Haller, Nelli Shushakova
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Critical Care Medicine
Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Benjamin Seeliger, Julius J. Schmidt, Heiko Schenk, Thorben Pape, Bernhard M. W. Schmidt, Tobias Welte, Marius M. Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller, Sascha David
Summary: Therapeutic plasma exchange using fresh frozen plasma may play a role in mitigating endothelial glycocalyx damage in patients with septic shock, reducing injurious degradation products and partially restoring protective factors.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2021)