Article
Cell Biology
Sandra Pinho, Qiaozhi Wei, Maria Maryanovich, Dachuan Zhang, Juan Carlos Balandran, Halley Pierce, Fumio Nakahara, Anna Di Staulo, Boris A. Bartholdy, Jianing Xus, Daniel K. Borger, Amit Verma, Paul S. Frenette
Summary: VCAM1 not only exists on healthy HSCs, but is also upregulated on leukaemic stem cells (LSCs), where it plays a 'don't-eat-me' role through interaction with MHC-I presentation, ensuring the integrity of HSCs when entering the bone marrow. The 'don't-eat-me' activity of VCAM1 is regulated by beta 2-microglobulin MHC presentation on HSCs and paired Ig-like receptor-B (PIR-B) on phagocytes. Additionally, VCAM1 is upregulated in cancer cells, providing an avenue for cancer cells to escape immune detection.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Yang, Yang Liu, Ziyan Wang, Minmin Lin, Chao Liu
Summary: Controlled anabolic mechanical loading enhances bone formation mainly through Type H vessels in a S1Pr1-dependent manner.
Article
Multidisciplinary Sciences
Stephanie Smith-Berdan, Alyssa Bercasio, Leah Kramer, Bryan Petkus, Lindsay Hinck, E. Camilla Forsberg
Summary: The study demonstrates the significant role of endothelial Robo4 in directional HSC trafficking, independent of alterations in VEC numbers and VCAM1 expression.
Article
Biochemistry & Molecular Biology
Giulia Furesi, Antonio Miguel de Jesus Domingues, Dimitra Alexopoulou, Andreas Dahl, Matthias Hackl, Johannes R. Schmidt, Stefan Kalkhof, Thomas Kurth, Hanna Taipaleenmaeki, Stefanie Conrad, Christine Hofbauer, Martina Rauner, Lorenz C. Hofbauer
Summary: Prostate cancer communicates with bone progenitor cells through extracellular vesicles, promoting vitality and proliferation of the progenitor cells while decreasing mineral deposition. Additionally, small RNAs released by prostate cancer cells may play a critical role in suppressing the activity of bone progenitor cells. These findings reveal an important communication mechanism between prostate cancer and bone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Sport Sciences
Bronwen Lundy, Alannah K. A. Mckay, Nikita C. Fensham, Nicolin Tee, Bryce Anderson, Aimee Morabito, Megan L. R. Ross, Marc Sim, Kathryn E. Ackerman, Louise M. Burke
Summary: Although acute exercise increases bone turnover markers, the impact of subsequent sessions and preexercise calcium intake remains unclear. This study found that preexercise intake of calcium-rich foods can stabilize blood calcium levels and reduce markers of bone resorption during exercise. These practical strategies can be integrated into athletes' sports nutrition plans to safeguard long-term bone health and reduce the risk of bone stress injuries.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Immunology
Annika Wiedemann, Marie Lettau, Ina Wirries, Annemarie Jungmann, Abdulrahman Salhab, Gilles Gasparoni, Henrik E. Mei, Carsten Perka, Joern Walter, Andreas Radbruch, Andreia C. Lino, Thomas Doerner
Summary: The study revealed distinct characteristics of IgA(+) BMPC in response to BCR stimulation, showing higher sensitivity to changes in the checkpoint molecule PD-1 compared to other PC subsets regardless of CD19 expression. This indicates that IgA(+) BMPC may have different regulatory functions independent of their phenotypic heterogeneity based on CD19 expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Hanghang Liu, Akane Wada, Isabella Le, Phuong T. Le, Andrew W. F. Lee, Jun Zhou, Francesca Gori, Roland Baron, Clifford J. Rosen
Summary: In mesenchymal progenitor cells, the conditional deletion of PTH1R or repression of Zfp467 can lead to increased transcription of Pth1r and enhanced responsiveness to PTH, ultimately resulting in increased bone formation.
Article
Endocrinology & Metabolism
Mikkel Bo Brent, Frederik Eriksen Stoltenborg, Annemarie Bruel, Jesper Skovhus Thomsen
Summary: The study found that abaloparatide and PTH have similar bone anabolic properties when compared directly mole-to-mole in mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shanyong Zhang, Lei Ding, Gaoyang Chen, Jiayin Zhang, Wanbao Ge, Yuan Qu
Summary: This study aimed to develop a Sr-HA/PTH1-34-loaded composite hydrogel system with high biocompatibility to improve bone induction property in bone tissue engineering and regenerative medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Roberto Pacifici
Summary: This article discusses the human microbiome, particularly the gut microbiome, and its role in regulating the skeletal effects of PTH, including mechanisms such as absorption and diffusion of bacterial metabolites and trafficking of immune cells from the gut to the bone marrow.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Krishna Bhan Singh, Reena Rai, Sonu Khanka, Divya Singh
Summary: This study investigated the potential of sequential treatment with NIL17 after PTH withdrawal as a promising therapeutic approach for osteoporosis. The results showed that SHIFT therapy could preserve bone density and microarchitectural parameters while suppressing osteoclast numbers, indicating its potential as a replacement therapeutic option post PTH discontinuation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Article
Anatomy & Morphology
Vinicius S. Carvalho, Jorge D. Rissino, Cleusa Y. Nagamachi, Julio C. Pieczarka, Renata C. R. Noronha
Summary: The study successfully established two new primary cell cultures derived from a South American bat, which could differentiate into osteogenic and adipogenic lineages. The chromosomal stability of the cells during passages 2, 4, 6, and 8 was also confirmed, indicating the potential utility of these cultures in investigating zoonotic diseases.
Article
Biochemistry & Molecular Biology
Hao Wang, Dongyue Zhang, Xiaoxi Cui, Yibo Dai, Chenchen Wang, Wenli Feng, Xiaoqian Lv, Yifei Li, Lina Wang, Yongxin Ru, Yingchi Zhang, Qian Ren, Guoguang Zheng
Summary: This study investigates the intrinsic effects of interferon regulatory factor 7 (IRF7) in acute myeloid leukemia (AML) and identifies a potential strategy to control central nervous system myeloid leukemia. The absence of IRF7 accelerates disease progression and AML cell invasion in the brain, while overexpression of IRF7 reduces cell proliferation and leukemia stem cell levels. Furthermore, blocking the VCAM1-VLA-4 axis delays disease progression and attenuates intracerebral invasion of AML cells.
Article
Chemistry, Medicinal
Jan Heering, Victor Hernandez-Olmos, Niklas Ildefeld, Ting Liu, Anja Kaiser, Zumer Naeem, Timo Froemel, Ingrid Fleming, Dieter Steinhilber, Ewgenij Proschak
Summary: This study describes the rational design of a fluorescent probe based on the synthetic BLT2 agonist CAY10583. The developed fluorescent ligands are suitable for investigating the pharmacology of BLT2 receptor ligands in various assay systems. The specific binding and modulation of BLT2-induced signaling by the fluorescent ligands were demonstrated.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)