Article
Chemistry, Physical
Mariana Brito da Cruz, Joana Faria Marques, Neusa Silva, Sara Madeira, Oscar Carvalho, Filipe Samuel Silva, Joao Carames, Antonio Mata
Summary: This study evaluated the response of periodontal hard tissue and soft tissue cells to microgroove-milled zirconia surfaces. The results showed that the milled microgroove texture did not affect the viability of gingival and bone cells, but it seemed to influence the cellular differentiation of osteoblasts.
Article
Chemistry, Physical
Nina Attik, Marina Phantarasmy, Hazem Abouelleil, Charlene Chevalier, Aurore Barraco, Brigitte Grosgogeat, Arnaud Lafon
Summary: This study assessed the topographical and physical properties of a minimally invasive implant and compared its biological behavior to a gold standard implant. The findings showed that both implants exhibited equivalent biological development for human gingival fibroblasts and osteoblast-like cells. In certain aspects, the minimally invasive implant performed better.
Article
Biochemistry & Molecular Biology
Susanne Jung, Marco Maria Moser, Johannes Kleinheinz, Arndt Happe
Summary: The surface roughness did not significantly affect cellular behavior, but there were slight differences between materials. Cells grown on zirconia dioxide exhibited higher cytotoxic effects, while those on lithium disilicate showed lower inflammation expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Morena Petrini, Tania Vanessa Pierfelice, Emira D'Amico, Natalia Di Pietro, Assunta Pandolfi, Camillo D'Arcangelo, Francesco De Angelis, Domitilla Mandatori, Valeria Schiavone, Adriano Piattelli, Giovanna Iezzi
Summary: Current research on dental implants has focused on the influence of surface roughness on osseointegration rate, while studies on developing surfaces to improve interaction with peri-implant soft tissues are lacking. This study showed that implant discs with Ti-S surfaces promoted adhesion and proliferation of gingival fibroblasts in vitro, suggesting their potential for in vivo applications. Further research is needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Gabriela de Souza Castro, Wanderson de Souza, Thais Suelen Mello Lima, Danielle Cabral Bonfim, Jacques Werckmann, Braulio Soares Archanjo, Jose Mauro Granjeiro, Ana Rosa Ribeiro, Sara Gemini-Piperni
Summary: This study compares the effects of different concentrations of TiO2 NPs on the differentiation and mineralized matrix production of human osteoblasts in a monolayer or 3D model. The internalization of nanoparticles and their impact on cell morphology are evaluated. The results demonstrate a dose-dependent increase in mineralized matrix in both the monolayer and 3D models, with higher levels observed in the 3D model after high exposure to TiO2 NPs, suggesting its potential as a model for testing the effect on bone osteointegration.
Article
Engineering, Biomedical
Supriya Kheur, Mohit Kheur, Vaibhav Madiwal, Ramandeep Sandhu, Tabrez Lakha, Jyutika Rajwade, Tan Firat Eyuboglu, Mutlu Ozcan
Summary: The efficacy of photofunctionalization on commercially available dental implant surfaces in a high-glucose environment was assessed in this study. XPS analysis showed that photofunctionalization altered the implant surface chemistry by reducing surface carbon content. Photofunctionalized discs promoted osteoblastic adhesion, viability, and mineralization in a high-glucose environment. Group 3 exhibited the best osteoblastic adhesion in the medium with increased glucose.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lais Medeiros Cardoso, Taisa Nogueira Pansani, Carlos Alberto de Souza Costa, Fernanda Goncalves Basso
Summary: This study aimed to assess the effects of pre-treatment with proanthocyanidins (PA) flavonoids, from grape seed extract, and synthetic naringenin (NA) on the synthesis of matrix metalloproteinases (MMPs) gelatinases and their tissue inhibitors (TIMPs), as well as the gelatinolytic activity of MMPs by human gingival fibroblasts (HGF) and osteoblasts (Ob) exposed to zoledronic acid (ZA) in a dental implant surface in vitro model. The results showed that pre-treatment with NA and PA effectively regulated the harmful effects of ZA, reducing the synthesis and activity of MMP-2 and MMP-9 by HGF and Ob, while up-regulating the synthesis of TIMP-2 by Ob.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mariana Brito da Cruz, Joana Faria Marques, Gabriella M. Penarrieta-Juanito, Mafalda Costa, Julio C. M. Souza, Ricardo S. Magini, Georgina Miranda, Filipe Samuel Silva, Joao Manuel Mendez Carames, Antonio Duarte Sola Pereira da Mata
Summary: This study aimed to characterize the mechanical properties of bioactive-modified PEEK manufacturing approach for dental implants and compare it with Ti6Al4V in vitro. The results showed that PEEK exhibited higher cell viability and proliferation for osteoblast and fibroblast cells compared to Ti6Al4V, but the addition of 5% HA or β-TCP did not enhance the mechanical properties or periodontal cell behavior of PEEK.
JOURNAL OF ORAL IMPLANTOLOGY
(2021)
Review
Engineering, Multidisciplinary
Michael B. Berger, Paul Slosar, Zvi Schwartz, David J. Cohen, Stuart B. Goodman, Paul A. Anderson, Barbara D. Boyan
Summary: The use of metallic and polymeric materials for implants has been increasing, but there is a lack of detailed information about their surface properties and the effects that various materials and surface modifications may have on bone formation. This article summarizes the science of surface modified bonefacing implants, focusing on biomimetic material chemistry and topography of titanium implants, to promote a better understanding of how these characteristics may impact bone formation and osseointegration.
Article
Engineering, Multidisciplinary
Mariana Brito da Cruz, Joana Faria Marques, Ana Filipa Silva Marques, Sara Madeira, Oscar Carvalho, Filipe Silva, Joao Carames, Antonio Duarte Sola Pereira da Mata
Summary: The aim of this study was to evaluate the response of gingival fibroblasts and human osteoblasts to textured Nd:YAG laser microgrooves with different dimensions on zirconia implant surfaces. The results showed that there were no significant differences in cell viability and differentiation between different microtopographic laser grooves and the traditional sandblasting and acid-etching surface treatment.
Article
Engineering, Biomedical
Keiji Komatsu, Takanori Matsuura, Toshikatsu Suzumura, Takahiro Ogawa
Summary: This study is the first to use RNA sequencing to investigate the genome-wide transcriptional profiling of osteoblasts in response to different titanium surface topographies. The findings reveal that osteoblasts on microrough surfaces exhibit upregulated expression of genes involved in immune system, stress/stimulus responses, proliferation control, and signaling pathways.
MATERIALS TODAY BIO
(2023)
Review
Immunology
Jagjit Singh Dhaliwal, Nurul Adhwa Abd Rahman, Long Chiau Ming, Sachinjeet Kaur Sodhi Dhaliwal, Joe Knights, Rubens Ferreira Albuquerque Junior
Summary: This systematic review focuses on decontamination methods of microbial biofilm on titanium implant surfaces used in dentistry. The review summarized 17 different groups of decontamination methods from 116 studies, with most methods proven effective in preventing biofilm formation and decontaminating established biofilm on dental implants.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ghada Alrabeah, Jonathan C. Knowles, Haralampos Petridis
Summary: The improved peri-implant bone response seen with the platform-switching concept may be due to the reduced release of metal ions from the implant-abutment surfaces. This study investigated the effect of different implant-abutment couplings on osteoblasts' function and found that platform-matched couplings resulted in higher rates of cell apoptosis and upregulation of genes related to bone resorption. These adverse biological responses may be associated with the increased release of metal ions from platform-matched couplings, indicating the potential role of corrosion products in crestal bone loss around dental implants.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Physical
Luca Fiorillo, Marco Cicciu, Tolga Fikret Tozum, Matteo Saccucci, Cristiano Orlando, Giovanni Luca Romano, Cesare D'Amico, Gabriele Cervino
Summary: In recent years, implantology has made significant progress, with the development of new alloys, surfaces, and geometries. This review analyzed the clinical differences between zirconia and titanium implants and found no statistically significant differences in fixed or overdenture restorations. However, there were concerns about the rigidity and potential fracture of zirconia.
Review
Biotechnology & Applied Microbiology
Chuang Hou, Jing An, Duoyi Zhao, Xiao Ma, Weilin Zhang, Wei Zhao, Meng Wu, Zhiyu Zhang, Fusheng Yuan
Summary: This article reviews the application and characteristics of titanium processing methods, explores the effects of technology on the surface characteristics of titanium-based implants, and proposes future research directions and the characteristics of ideal titanium-based implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Po-Sung Fu, Jen-Chyan Wang, Pei-Ling Lai, Shih-Ming Liu, Ya-Shun Chen, Wen-Cheng Chen, Chun-Cheng Hung
Summary: This study evaluated the properties of biodegradable hydrogel beads with calcium phosphate bone cement. The results showed that adding hydrogel beads to the cement did not inhibit cell proliferation and differentiation, and the composite material has potential for dental, craniofacial, and orthopedic applications.
Article
Polymer Science
Yi-Sheng Jiang, Ming-Hsien Hu, Jeng-Shiung Jan, Jin-Jia Hu
Summary: This study aimed to retard the degradation rate of Poly(glycerol sebacate) (PGS) by incorporating L-glutamic acid into its network. The results showed that the introduction of L-glutamic acid formed peptide bonds which led to altered mechanical properties and retarded degradation kinetics of the elastomer. It was found that PGSE displayed a lower degradation rate and different mechanical properties compared to PGS, making it a potential scaffold material for tissues with a low healing rate.
Article
Dentistry, Oral Surgery & Medicine
Pei -Ling Lai, Chin-Tzu Yeh, Po-Sung Fu, Jen-Hao Chen, Ting-Hsun Lan, Jen-Chyan Wang, Wen-Cheng Chen, Chun-Cheng Hung
Summary: The purpose of this study was to investigate the effect of an argon-arc vacuum pressure casting process on the recasting of Pd-Ag alloy. The results showed that compared to horizontal centrifugal casting, the argon-arc vacuum pressure casting process had better edge precision, smaller oxide layer thickness, and lower hardness. X-ray diffraction intensity analysis revealed higher relative intensities of Pd and Ag in the recasting of the argon-arc vacuum pressure casting group. Phase analysis showed higher trace element contents of indium and tin in the Pd-Ag recasting ingots of the argon-arc vacuum pressure casting group than in the horizontal centrifugal casting group.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chih-Hsin Cheng, Ya-Shun Chen, Hsu -Ting Chang, Kai -Chi Chang, Ssu-Meng Huang, Shih-Ming Liu, Wen-Cheng Chen
Summary: This study aimed to develop biodegradable millimeter-scale spherical hydrogel beads with highly interconnected pores that can effectively serve dual functions for cell growth and antibiotic release. Sodium alginate and gelatin were used as the matrix, which were synergistically cross-linked using different ratios of cross-linkers. The physicochemical properties of the beads were measured, and gentamicin-impregnated hydrogel beads showed better antibacterial activity compared to hydrogel without antibiotics. The developed hydrogel beads have good antibacterial activity, and can be used in combination with different medical devices to improve biocompatibility and reduce the risk of surgical failure caused by infection.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Kun Gou, Jin-Jia Hu, Seungik Baek
Summary: Decellularized human umbilical artery (HUA) can be used as tissue-engineered vascular grafts for small-diameter applications, and removal of the abluminal lining layer improves its compliance. Mechanical characterization of the HUA before and after abluminal lining removal reveals increased compliance and circumferential wall stress.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Polymer Science
Ssu-Meng Huang, Shih-Ming Liu, Hua-Yi Tseng, Wen-Cheng Chen
Summary: In this study, electrospun polyvinyl alcohol (PVA) fiber membranes were crosslinked with citric acid (CA) at different concentrations. The effects of CA on the chemical structure, mechanical strength, swelling resistance, and cytotoxicity of the crosslinked PVA membranes were investigated. The results showed that CA crosslinking improved the modulus and strength of the membranes, increased swelling resistance, and had no cytotoxic effects at low concentrations of PVA.
Article
Polymer Science
Kai-Chi Chang, Pei-Jheng Chang, Jian-Chih Chen, Ssu-Meng Huang, Shih-Ming Liu, Chi-Jen Shih, Wen-Cheng Chen
Summary: Hydrogel-based microspheres were prepared using gelatin, paraffin oil, and Span 80, and the biocompatibility was improved by adding DAP or PC. DAP-modified microspheres showed better biocompatibility compared to PC. The microspheres degraded completely after 26 days in PBS. This drug carrier can be combined with other biomaterial matrices to achieve localized therapeutic effects and improve drug bioavailability.
Article
Chemistry, Physical
Kuie-Bin Chang, Parag Parashar, Li -Chien Shen, An-Rong Chen, Yan-Tsz Huang, Arnab Pal, Kee-Chin Lim, Po-Han Wei, Fu-Cheng Kao, Jin-Jia Hu, Zong-Hong Lin
Summary: This study proposes a self-powered triboelectric nanogenerator (TENG) based flexible tactile sensor array system for real-time monitoring of pressure distribution inside a prosthetic socket. The sensor is made of biocompatible PDMS polymer and PCL nanofiber membranes as triboelectric materials, providing high stability and low cost. Integration of the sensor array within a prosthetic device enables real-time monitoring of pressure distribution during gait simulation.
Article
Chemistry, Medicinal
Shih-Ming Liu, Jian-Chih Chen, Ssu-Meng Huang, Shang-Hong Lin, Wen-Cheng Chen
Summary: This study compares the performance of anti-osteoporotic drugs ALN and FA impregnated into nanoparticles of mesoporous bioactive glass (nMBG) composites with calcium phosphate cement (CPC). The drug release, physicochemical properties, and biocompatibility of the nMBG@CPC composite bone cement are tested, as well as the effect on the proliferation and differentiation efficiency of mouse precursor osteoblasts (D1 cells).
Article
Biochemistry & Molecular Biology
Ssu-Meng Huang, Shih-Ming Liu, Hua-Yi Tseng, Wen-Cheng Chen
Summary: In this experiment, a multilayer membrane made of polyvinyl alcohol (PVA) and gelatin was prepared by continuous electrospinning. The membrane exhibited slow drug release and showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.
Article
Dentistry, Oral Surgery & Medicine
Po-Sung Fu, Ting-Hsun Lan, Pei-Ling Lai, Cheng-Hwei Chen, Jen-Hao Chen, Jen-Chyan Wang, Chih-Te Liu, Wen-Cheng Chen, Chun-Cheng Hung
Summary: This study investigated the impact of age, gender, bone density, implant length, and diameter on implant stability, as well as the influence of these factors on marginal bone loss. Ninety patients received implant therapy, and the results showed that implant diameter had a stronger effect on implant stability compared to length. Bone density also played a significant role in determining implant stability. Additionally, both bone density and implant torque had a greater impact on marginal bone loss compared to implant stability quotient (ISQ).
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Po-Sung Fu, Fei-Chi Tseng, Ting-Hsun Lan, Pei -Ling Lai, Cheng-Hwei Chen, Jen-Hao Chen, Chih-Te Liu, Wen-Cheng Chen, Chun-Cheng Hung
Summary: The aim of this study was to compare the effects of immediate implant placement with and without immediate provisionalization on implant stability, marginal bone loss, survival rates, and patient satisfaction. The results showed that immediate implant placement with immediate provisionalization had significantly higher implant stability and patient satisfaction compared to immediate implant placement without immediate provisionalization, but there were no significant differences between the two groups in terms of marginal bone loss and survival.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Materials Science, Biomaterials
Ssu-Meng Huang, Wen-Cheng Chen, Cheng-Chen Wu, Shih-Ming Liu, Chia-Ling Ko, Jian-Chih Chen, Chi-Jen Shih
Summary: This study aimed to release gentamicin sulfate to reduce tissue inflammation and prevent infection, and to release ferulic acid to accelerate the overall bone repair. Different particle properties of micro-nano hybrid mesoporous bioactive glass (MBG) were explored to generate different dose releases in MBG/CPC composite bone cement. The developed MBG/CPC composite bone cement can achieve the synergistic sustained release of antibacterial and osteoconductive activities.
BIOMATERIALS ADVANCES
(2023)
Article
Materials Science, Biomaterials
Wen-Cheng Chen, Bo-Yuan Huang, Ssu-Meng Huang, Shih-Ming Liu, Kai-Chi Chang, Chia-Ling Ko, Chih-Lung Lin
Summary: A polyvinylidene fluoride (PVDF) piezoelectric membrane with carbon nanotubes (CNTs) and graphene oxide (GO) additives was prepared, and the piezoelectric activity of aligned fibers was studied. The electrospun microstructures were anisotropically aligned fibers. The addition of GO and CNT affected the growth of the β phase in PVDF, and GO/PVDF showed better performance than CNT/PVDF composites. The piezoelectric membrane exhibited excellent piezoelectric voltages that promoted cell differentiation and mineralization.
BIOMATERIALS ADVANCES
(2023)
Article
Engineering, Multidisciplinary
Ming-Hsien Hu, Pei-Yi Chu, Ssu-Meng Huang, Bo-Sin Shih, Chia-Ling Ko, Jin-Jia Hu, Wen-Cheng Chen
Summary: The composite bone cement of calcium phosphate cement (CPC) and mesoporous bioactive glass (MBG) shows potential advantages in clinical applications, with good injectability and disintegration resistance. However, increasing the MBG content decreases the working/setting time and compressive strength.
