4.7 Letter

Question answering systems in biology and medicine-the time is now

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Neurosciences

The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

David A. Buckley, Elaine M. Jennings, Nikita N. Burke, Michelle Roche, Veronica McInerney, Jonathan D. Wren, David P. Finn, Patrick C. McHugh

MOLECULAR NEUROBIOLOGY (2018)

Article Cell Biology

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

Sathyaseelan S. Deepa, Gavin Pharaoh, Michael Kinter, Vivian Diaz, Wilson C. Fok, Kaitlyn Riddle, Daniel Pulliam, Shauna Hill, Kathleen E. Fischer, Vanessa Soto, Constantin Georgescu, Jonathan D. Wren, Carlo Viscomi, Arlan Richardson, Holly Van Remmen

AGING CELL (2018)

Article Biochemistry & Molecular Biology

Tetraspanin-enriched microdomains regulate digitation junctions

Chao Huang, Chenying Fu, Jonathan D. Wren, Xuejun Wang, Feng Zhang, Yanhui H. Zhang, Samuel A. Connel, Taosheng Chen, Xin A. Zhang

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Article Biochemistry & Molecular Biology

Algorithmically outsourcing the detection of statistical errors and other problems

Jonathan D. Wren

EMBO JOURNAL (2018)

Article Immunology

CD4+CD28+KIR+CD11 a(hi) T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients

Elizabeth Gensterblum, Paul Renauer, Patrick Coit, Faith M. Strickland, Nathan C. Kilian, Shaylynn Miller, Mikhail Ognenovski, Jonathan D. Wren, Pei-Suen Tsou, Emily E. Lewis, Kathleen Maksimowicz-McKinnon, W. Joseph McCune, Bruce C. Richardson, Amr H. Sawalha

JOURNAL OF AUTOIMMUNITY (2018)

Review Cardiac & Cardiovascular Systems

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

Zoltan Ungvari, Stefano Tarantini, Tamas Kiss, Jonathan D. Wren, Cory B. Giles, Courtney T. Griffin, Walter Lee Murfee, Pal Pacher, Anna Csiszar

NATURE REVIEWS CARDIOLOGY (2018)

Article Cell & Tissue Engineering

Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model

Evan Fields, Jonathan D. Wren, Constantin Georgescu, John R. Daum, Gary J. Gorbsky

STEM CELL RESEARCH (2018)

Article Immunology

ARID3a gene profiles are strongly associated with human interferon alpha production

Michelle L. Ratliff, Joshua Garton, Lori Garman, M. David Barron, Constantin Georgescu, Kathryn A. White, Eliza Chakravarty, Jonathan D. Wren, Courtney G. Montgomery, Judith A. James, Carol F. Webb

JOURNAL OF AUTOIMMUNITY (2019)

Article Biochemistry & Molecular Biology

CAGm: a repository of germline microsatellite variations in the 1000 genomes project

Nicholas Kinney, Kyle Titus-Glover, Jonathan D. Wren, Robin T. Varghese, Pawel Michalak, Han Liao, Ramu Anandakrishnan, Arichanah Pulenthiran, Lin Kang, Harold R. Garner

NUCLEIC ACIDS RESEARCH (2019)

Editorial Material Biochemical Research Methods

Reviewer-coerced citation: case report, update on journal policy and suggestions for future prevention

Jonathan D. Wren, Alfonso Valencia, Janet Kelso

BIOINFORMATICS (2019)

Article Cell Biology

CSAG1 maintains the integrity of the mitotic centrosome in cells with defective p53

Hem Sapkota, Jonathan D. Wren, Gary J. Gorbsky

JOURNAL OF CELL SCIENCE (2020)

Article Medicine, Research & Experimental

Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Joshua M. Corbin, Constantin Georgescu, Jonathan D. Wren, Chao Xu, Adam S. Asch, Maria J. Ruiz-Echevarria

Summary: Resistance to anti-androgen therapy in prostate cancer is often driven by genetic and epigenetic aberrations in androgen receptor and coregulatory genes. Specific small RNAs can downregulate essential genes, leading to potent androgen signaling inhibition and cell death. Targeting TMEFF2 with short hairpin/small interfering RNAs may be a novel therapeutic strategy for prostate cancer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Immunology

Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors

Liangyue Qian, Sandra Bajana, Constantin Georgescu, Vincent Peng, Hong-Cheng Wang, Indra Adrianto, Marco Colonna, Jose Alberola-Ila, Jonathan D. Wren, Xiao-Hong Sun

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biochemical Research Methods

Algorithmic identification of discrepancies between published ratios and their reported confidence intervals and P-values

Constantin Georgescu, Jonathan D. Wren

BIOINFORMATICS (2018)

Meeting Abstract Rheumatology

Sjogren's syndrome minor salivary gland CD4+ T cells associate with oral disease features and have a T follicular helper-like transcriptional profile

Michelle L. Joachims, Kerry M. Leehan, Mikhail G. Dozmorov, Zijian Pan, Astrid Rasmussen, Lida Radfar, David M. Lewis, Donald U. Stone, Kiely Grundahl, R. Hal Scofield, Christopher J. Lessard, Jonathan Wren, Kathy L. Sivils, Jacen Maier-Moore, A. Darise Farris

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2018)

No Data Available