Journal
BIOFACTORS
Volume 38, Issue 2, Pages 98-106Publisher
WILEY
DOI: 10.1002/biof.199
Keywords
Alzheimer's disease; amyloid beta peptide; preclinical Alzheimer's disease; zinc; zinc transporter proteins; mild clinical impairment
Funding
- NIH [P30-AG028383, 1RO1-AG16269]
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Alzheimer's disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (A beta) peptide generation and aggregation.
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