New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies

Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo

(2010) Shigeto Miura et al.   DEVELOPMENTAL BIOLOGY

rhBMP-2 Induces Transient Bone Resorption Followed by Bone Formation in a Nonhuman Primate Core-Defect Model

(2010) Howard J. Seeherman et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Duplications Involving a Conserved Regulatory Element Downstream of BMP2 Are Associated with Brachydactyly Type A2

(2009) Katarina Dathe et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes

(2009) M. Asai-Coakwell et al.   HUMAN MOLECULAR GENETICS

Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies

(2009) M. Ye et al.   HUMAN MOLECULAR GENETICS

Identification of Progenitor Cells That Contribute to Heterotopic Skeletogenesis

(2009) Vitali Y Lounev et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts

(2009) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mutations in BMP4 Cause Eye, Brain, and Digit Developmental Anomalies: Overlap between the BMP4 and Hedgehog Signaling Pathways

(2008) Preeti Bakrania et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

(2008) N. Kamiya et al.   DEVELOPMENT

Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass*

(2008) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Endochondral ossification is required for haematopoietic stem-cell niche formation

(2008) Charles K. F. Chan et al.   NATURE

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

Endochondral ossification: How cartilage is converted into bone in the developing skeleton

(2007) E.J. Mackie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Essential Requirement of BMPs-2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin

(2006) Etsuko Abe et al.   JOURNAL OF BONE AND MINERAL RESEARCH