Article
Plant Sciences
Masao Yamasaki, Yusei Kiue, Kento Fujii, Moe Sushida, Yumi Yamasaki, Kazuhiro Sugamoto, Yosuke Suzuki, Yasuko Koga, Hisato Kunitake, Hisahiro Kai, Kenjiro Ogawa, Kazuo Nishiyama, Yo Goto, Takayuki Nakayama
Summary: Blueberry leaf extract (BLEx) has been found to suppress lipid accumulation and uric acid production in adipocytes, mainly due to the highly polymerized proanthocyanidin-rich fraction. Additionally, BLEx can inhibit uric acid production in adipocytes under hypoxic conditions.
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Nutrition & Dietetics
Sakan Warinhomhoun, Hnin Ei Ei Khine, Boonchoo Sritularak, Kittisak Likhitwitayawuid, Tomofumi Miyamoto, Chiaki Tanaka, Chuchard Punsawad, Yanyong Punpreuk, Rungroch Sungthong, Chatchai Chaotham
Summary: This study isolated six compounds from an orchid species and identified one compound (compound 3) with potential anti-obesity effects. Compound 3 reduced lipid storage in adipocytes and suppressed the expression of key transcription factors involved in adipocyte differentiation, as well as proteins in the MAPK pathway.
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Summary: The study found that OSM induces adipocyte lipolysis via the p66Shc-ERK pathway, inhibiting the suppression of lipolysis by insulin, and inducing phosphorylation of inhibitory IRS1 residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Catarina Teixeira, Andre P. Sousa, Ines Santos, Ana Catarina Rocha, Ines Alencastre, Ana Claudia Pereira, Daniela Martins-Mendes, Pedro Barata, Pilar Baylina, Ruben Fernandes
Summary: This study demonstrates that pioglitazone enhances adipocyte differentiation and secretome production, making it an excellent model for studying adiposity. The study also proposes an improved method for adipocyte secretome production, which can be used for experimental biology studies to understand the molecular mechanisms underlying the influence of adiposity on other cells.
Article
Immunology
Bruno Mendes, Karen Minori, Silvio R. Consonni, Norma W. Andrews, Danilo C. Miguel
Summary: Recent research has shown that adipocytes may serve as potential host cells for New World Leishmania species. The study demonstrates that both L. (L.) amazonensis and L. (V.) braziliensis can infect and survive within adipocytes, forming parasitophorous vacuoles similar to those observed in macrophages.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoqin Liang, Shengping Deng, Yan Huang, Liwei Pan, Yanling Chang, Ping Hou, Chenyang Ren, Weifeng Xu, Ruiyun Yang, Kanyuan Li, Jun Li, Ruijie He
Summary: By analyzing the structures of natural compounds isolated from Cyclocarya paliurus leaves and conducting experiments, it was found that three of these compounds have stimulating effects on glucose uptake in adipocytes under insulin stimulation, showing a dose-dependent relationship. This suggests the potential application of abundant natural compounds from C. paliurus leaves in the treatment of diabetes.
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Biochemistry & Molecular Biology
Xue-Lin Chen, Kun Zhang, Xia Zhao, Han-Lei Wang, Mei Han, Ru Li, Zhen-Nan Zhang, Yu-Mei Zhang
Summary: Three new triterpenes and fourteen known triterpenoids were isolated from Kochiae Fructus, and their structures were elucidated. Compound 13 showed potent effect on glucose uptake in adipocytes. Compounds 3, 9, and 13 exhibited significant inhibitory activities against alpha-glucosidase, with their inhibitory activities and binding capacities with alpha-glucosidase reported for the first time. These compounds could have therapeutic potentials for type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hayley C. Jackson, Carmen Pheiffer, Babalwa Jack, Donita Africander
Summary: This study provides an inexpensive model that mimics the characteristics of obesity by manipulating the time of adipocyte differentiation and increasing the glucose concentration. The results show that adipocyte hypertrophy, ROS production, IL-6 gene expression, lipolysis, and MCP1 gene expression are dependent on glucose and time. In addition, the hypertrophic model exhibits significantly higher expression of steroidogenic enzymes and enhanced conversion of cortisone and androstenedione. These characteristics make hypertrophic 3T3-L1 adipocytes an appropriate in vitro model to study adipocyte dysfunction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Toshihiro Tanioka, Kohei Maeda, Rei Takahashi, Sanju Iwamoto
Summary: The study revealed that Ang III enhances glucose uptake via upregulating GLUT1 expression through AT2R, while AT1R is not involved in this regulatory process.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Su Bu, Anran Xiong, Zhiying Yang, Faycal Aissa-Brahim, Ying Chen, Yichun Zhang, Xunyong Zhou, Fuliang Cao
Summary: Bilobalide exhibits beneficial bioactivities such as neuroprotection, anti-inflammation, and antioxidant effects. The study demonstrates that bilobalide can induce apoptosis in mature adipocytes through the ROS-mediated mitochondrial pathway.
Article
Food Science & Technology
Tomoki Abe, Tomoyuki Sato, Kazutoshi Murotomi
Summary: Polymethoxyflavones found in citrus fruit peels, such as sudachitin and nobiletin, have beneficial effects on obesity and diabetes by promoting lipolysis in adipocytes. This study demonstrated that sudachitin and nobiletin increased intracellular levels of cAMP and medium glycerol in 3T3-L1 adipocytes. Furthermore, they also increased protein levels of phosphorylated PKA substrates and phosphorylated HSL. The anti-obesogenic effects of sudachitin are mediated, at least in part, by the induction of lipolysis in adipocytes.
Article
Biochemistry & Molecular Biology
Mi-Jin Oh, Hye-Bin Lee, Guijae Yoo, Miri Park, Chang-Hyun Lee, Inwook Choi, Ho-Young Park
Summary: The study evaluated the anti-obesity effect of water-soluble red pepper leaf extract on adipocytes and HFD-fed mice. The findings showed that the extract reduced fat accumulation and improved intestinal health, suggesting its potential in preventing obesity.
Article
Cell Biology
Jie Pan, Suchart Kothan, Laihao Liu, Aye Thidar Moe, Liwei Dong, Yanan Sun, Yiyi Yang
Summary: Our study demonstrated that autophagy is positively related to the dedifferentiation of 3T3-L1 adipocytes and is regulated through the insulin-PI3K-AKT-mTORC1-autophagy pathway. Additionally, autophagy may have a certain degree of negative feedback affect on the insulin signaling of 3T3-L1 cells.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Shin Nishiumi, Seiji Fujigaki, Takashi Kobayashi, Takashi Kojima, Yoshinori Ito, Hiroyuki Daiko, Ken Kato, Hirokazu Shoji, Yuzo Kodama, Kazufumi Honda, Masaru Yoshida
ANTICANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Ryoma Tagawa, Yuki Kawano, Akihiro Minami, Shin Nishiumi, Yoshihiko Yano, Masaru Yoshida, Yuzo Kodama
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Cell Biology
Naoyuki Sugiyama, Satomi Miyake, Miao-Hsia Lin, Masaki Wakabayashi, Hiroyuki Marusawa, Shin Nishiumi, Masaru Yoshida, Yasushi Ishihama
Article
Chemistry, Analytical
Shin Nishiumi, Tomohiro Kohata, Takashi Kobayashi, Yuzo Kodama, Sumio Ohtsuki, Masaru Yoshida
Article
Oncology
Takao Iemoto, Shin Nishiumi, Takashi Kobayashi, Seiji Fujigaki, Tetsuya Hamaguchi, Ken Kato, Hirokazu Shoji, Yasuhiro Matsumura, Kazufumi Honda, Masaru Yoshida
Article
Nutrition & Dietetics
Shin Nishiumi, Yoshihiro Izumi, Takashi Kobayashi, Masaru Yoshida
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Koki Matsuoka, Shin Nishiumi, Masaru Yoshida, Yuzo Kodama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Madoka Nambu, Shin Nishiumi, Takashi Kobayashi, Takeshi Masuda, Shingo Ito, Masaru Yoshida, Sumio Ohtsuki
JOURNAL OF PROTEOMICS
(2020)
Article
Medicine, Research & Experimental
Ryota Nakano, Shin Nishiumi, Takashi Kobayashi, Takuya Ikegawa, Yuzo Kodama, Masaru Yoshida
BIOMARKERS IN MEDICINE
(2020)
Article
Oncology
Yu Sato, Takashi Kobayashi, Shin Nishiumi, Akihiko Okada, Tsuyoshi Fujita, Tsuyoshi Sanuki, Masao Kobayashi, Masakyo Asahara, Masayasu Adachi, Arata Sakai, Hideyuki Shiomi, Atsuhiro Masuda, Masaru Yoshida, Keiko Takeuchi, Yuzo Kodama, Hiromu Kutsumi, Kengo Nagashima, Kazufumi Honda
Article
Cell Biology
Takashi Nakanishi, Hirokazu Fukui, Xuan Wang, Shin Nishiumi, Haruka Yokota, Yutaka Makizaki, Yoshiki Tanaka, Hiroshi Ohno, Toshihiko Tomita, Tadayuki Oshima, Hiroto Miwa
Summary: High-fat diet-induced dysbiosis in the small intestine leads to pathological changes in the luminal environment, disruption of small-intestinal mucosal integrity, and minimal inflammation in the gut-liver axis, ultimately resulting in the development of steatohepatitis in mice.
Article
Biochemistry & Molecular Biology
Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M. Tokuoka, Yoshihiro Kita, Fumie Hamano, Nobuyuki Okahashi, Kazutaka Ikeda, Hiroki Nakanishi, Kosuke Saito, Masami Yokota Hirai, Masaru Yoshida, Yoshiya Oda, Fumio Matsuda, Takeshi Bamba
Summary: In mass spectrometry-based metabolomics, the differences in analytical results from different laboratories/machines are a concern. This study evaluates inter-laboratory differences in metabolomic analysis and finds that the variations are primarily due to measurement and data analysis rather than sample preparation. These findings are important for understanding the challenges in metabolomics studies involving multiple laboratories.
Meeting Abstract
Gastroenterology & Hepatology
K. Honda, T. Kobayashi, Y. Sato, S. Nishiumi, S. Okaya, K. Takeuchi, K. Nagashima, M. Yoshida
Article
Food Science & Technology
Shin Nishiumi, Yoshihiro Izumi, Takashi Kobayashi, Masaru Yoshida
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2019)
Meeting Abstract
Gastroenterology & Hepatology
I. Kobayashi, K. Hanada, M. Fukuyo, K. Yahara, H. Yonezawa, Venclovas, Y. Katsura, A. Toyoda, S. Nishiumi, T. Azuma, M. Kato
