Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

(2015) Hyun-Soo Cho et al.   NEOPLASIA

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

(2014) Ryuji Hamamoto et al.   CANCER LETTERS

Overexpression of G9a and MCM7 in oesophageal squamous cell carcinoma is associated with poor prognosis

(2014) Xinwen Zhong et al.   HISTOPATHOLOGY

The functional diversity of protein lysine methylation

(2014) S. Lanouette et al.   Molecular Systems Biology

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases

(2014) F Yeung et al.   ONCOGENE

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation

(2013) Magnus E. Jakobsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic protein methylation is essential for neural crest migration

(2013) Katie L. Vermillion et al.   JOURNAL OF CELL BIOLOGY

SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription

(2013) Cheng Liu et al.   JNCI-Journal of the National Cancer Institute

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Context-specific regulation of cancer epigenomes by histone and transcription factor methylation

(2013) M Sarris et al.   ONCOGENE

Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis

(2013) E. J. Hartsough et al.   Science Signaling

Tipping the lysine methylation balance in disease

(2012) Joshua C. Black et al.   BIOPOLYMERS

Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression

(2012) M. Takawa et al.   CANCER RESEARCH

Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death

(2012) Qi Xie et al.   EMBO REPORTS

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

(2012) Glenn S. Van Aller et al.   Epigenetics

PRC2 directly methylates GATA4 and represses its transcriptional activity

(2012) A. He et al.   GENES & DEVELOPMENT

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

(2012) Moon-Chang Choi et al.   MOLECULAR CELL

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Regulation of RAS oncogenicity by acetylation

(2012) M. H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

(2012) M. T. McCabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B

(2012) Hyun-Soo Cho et al.   Nature Communications

Lysine methylation: beyond histones

(2011) Xi Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase MMP-9

(2011) A. M. Cock-Rada et al.   CANCER RESEARCH

Specificity Analysis-Based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase

(2011) Arunkumar Dhayalan et al.   CHEMISTRY & BIOLOGY

Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signalling pathways

(2011) Toshiaki Watanabe et al.   EUROPEAN JOURNAL OF CANCER

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

(2011) Yuji Kubota et al.   NATURE CELL BIOLOGY

A proteomic approach for the identification of novel lysine methyltransferase substrates

(2011) Dan Levy et al.   Epigenetics & Chromatin

Regulation of p53 function by lysine methylation

(2011) Lisandra E West et al.   Epigenomics

The Ras-ERK pathway: Understanding site-specific signaling provides hope of new anti-tumor therapies

(2010) Fernando Calvo et al.   BIOESSAYS

Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma

(2010) Gerben Duns et al.   CANCER RESEARCH

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

(2010) Takeshi Maruyama et al.   EMBO JOURNAL

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

(2010) Jochen Gaedcke et al.   GENES CHROMOSOMES & CANCER

Methylation of the Retinoblastoma Tumor Suppressor by SMYD2

(2010) Louis A. Saddic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression

(2010) Lisandra E. West et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

(2010) Jason S. Lee et al.   MOLECULAR CELL

Lysine Methylation Regulates E2F1-Induced Cell Death

(2010) Haroula Kontaki et al.   MOLECULAR CELL

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Lysine methylation regulates the pRb tumour suppressor protein

(2010) S Munro et al.   ONCOGENE

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

(2010) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of SMYD3 by RNA interference down-regulates c-Met expression and inhibits cells migration and invasion induced by HGF

(2009) Jia-Ning Zou et al.   CANCER LETTERS

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

(2009) Shuhei Komatsu et al.   CARCINOGENESIS

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

(2009) G Liu et al.   ONCOGENE

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

(2009) P.-O. Esteve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone methyltransferases in cancer

(2009) Mareike Albert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

G9a-mediated Lysine Methylation Alters the Function of CCAAT/Enhancer-binding Protein-β

(2008) Ole Pless et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Retinoic Acid Receptor Alpha Activity by Lysine Methylation in the DNA Binding Domain

(2008) M. D. Mostaqul Huq et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

(2008) Krithika Subramanian et al.   MOLECULAR CELL

Protein lysine methyltransferase G9a acts on non-histone targets

(2008) Philipp Rathert et al.   Nature Chemical Biology