Journal
BIOESSAYS
Volume 36, Issue 6, Pages 598-605Publisher
WILEY
DOI: 10.1002/bies.201400018
Keywords
admixture; ancient DNA; genomics; human evolution; mitochondrial DNA; next-generation sequencing
Categories
Funding
- Danish National Research Foundation [DNRF94]
- FNU
- Marie-Curie FP7 Career Integration Grant program [CIG293845]
Ask authors/readers for more resources
By combining state-of-the-art approaches in ancient genomics, Meyer and co-workers have reconstructed the mitochondrial sequence of an archaic hominin that lived at Sierra de Atapuerca, Spain about 400,000 years ago. This achievement follows recent advances in molecular anthropology that delivered the genome sequence of younger archaic hominins, such as Neanderthals and Denisovans. Molecular phylogenetic reconstructions placed the Atapuercan as a sister group to Denisovans, although its morphology suggested closer affinities with Neanderthals. In addition to possibly challenging our interpretation of the fossil record, this study confirms that genomic information can be recovered from extremely damaged DNA molecules, even in the presence of significant levels of human contamination. Together with the recent characterization of a 700,000-year-old horse genome, this study opens the Middle Pleistocene to genomics, thereby extending the scope of ancient DNA to the last million years.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available