Review
Pharmacology & Pharmacy
Wen-Hao Li, Fei Wang, Gui-Yuan Song, Qing-Hua Yu, Rui-Peng Du, Ping Xu
Summary: This review provides a comprehensive analysis of the role of PARP-1 in DNA repair and protein modification, as well as its interaction with DNA damage repair mechanisms and key transcription factors. It is found that PARP-1 plays a critical role in radiation injury, and PARP-1 inhibitors have the potential to improve the clinical outcomes of radiation damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
ElHusseiny M. M. Abdelwahab, Judit Bovari-Biri, Gabor Smuk, Janos Fillinger, Donald McPhail, Vera P. Krymskaya, Judit E. Pongracz
Summary: This study investigates the deregulation of cell death processes in TSC mutation, and identifies a potential treatment strategy involving the use of Proxison and rapamycin in combination to increase ROS production, modify miRNA expression pattern, and reduce cell viability.
Article
Biochemistry & Molecular Biology
Ling-Ya Chiu, Duen-Yi Huang, Wan-Wan Lin
Summary: PARP-1 positively regulates NLRP3 inflammasome activation by increasing ROS production and interacting with TXNIP and NLRP3.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Robert L. Fine, Yuehua Mao, Richard Dinnen, Ramon V. Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N. Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W. Brandt-Rauf
Summary: This study improved the synthetic p53 C-terminal peptide and demonstrated its enhanced selective apoptosis effect on mutant p53 malignant cells without toxicity to normal cells. The modified peptide formed a structure similar to the p53 tetramer, which increased stability and activity.
Article
Cell Biology
Wunan Mi, Chuyue Wang, Guang Luo, Jiehan Li, Yizheng Zhang, Meimei Jiang, Chuchu Zhang, Nannan Liu, Xinxiu Jiang, Ge Yang, Lingling Zhang, Ge Zhang, Yingjie Zhang, Yang Fu
Summary: This study demonstrates that CC90003 induces autophagy by activating ROS/p53, leading to cell death in colorectal cancer. Combination treatment with CC90003 plus CQ shows significant efficacy in the xenograft mouse model, providing new potential targets for clinical therapy.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Rajesh Kumar Meher, Showkat Ahmad Mir, Siva Shanker Anisetti
Summary: This study investigates the binding of Prima-1(MET) with p53 and the tyrosine kinase of epidermal growth factor receptor. The results show that Prima-1(MET) exhibits strong binding affinity with both targets and remains stable in molecular dynamics simulations. The study also evaluates the cytotoxicity of Prima-1(MET) in lung cancer cells and demonstrates its inhibitory effect.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Environmental Sciences
Natsumi Fujiwara, Shohei Yamashita, Motoki Okamoto, Marion A. Cooley, Kazumi Ozaki, Eric T. Everett, Maiko Suzuki
Summary: In this study, it was found that perfluorooctanoic acid (PFOA) negatively affects tooth enamel development through cell death mechanisms involving necrosis/necroptosis and apoptosis, mediated by the ROS-MAPK/ERK signaling pathway. PFOA also suppressed cell proliferation and viability. This research provides initial evidence that PFOA could potentially contribute to cryptogenic enamel malformation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Yan Sun, Ambroise Manceau, Lisa Frydman, Lucie Cappuccio, David Neves, Valeria Basso, Hong Wang, Joanna Fombonne, Carine Maisse, Patrick Mehlen, Andrea Paradisi
Summary: Netrin-1, a secreted protein known as a relevant cancer therapeutic target, promotes cancer progression by inhibiting cell death induced by its receptors. The study shows that p53 positively regulates Netrin-1 gene expression, and the A40p53 isoform can activate the Netrin-1 promoter to promote cell survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Min Ling, Qing Liu, Yufei Wang, Xueting Liu, Manli Jiang, Jinyue Hu
Summary: Gliomas have high morbidity and mortality rates, and current treatments have only slightly improved survival. This study found that inhibiting SOD1, which is highly expressed in glioma tissues, can induce cell death and activate the ROS signal pathway. Inhibition of SOD1 also led to the degradation of PARP and BRCA1, suggesting a potential mechanism for glioma therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose D. D. Puentes-Pardo, Sara Moreno-SanJuan, Jorge Casado, Julia Escudero-Feliu, David Lopez-Perez, Paula Sanchez-Uceta, Paula Gonzalez-Novoa, Julio Galvez, Angel Carazo, Josefa Leon
Summary: Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in various physiological processes. Elevated PARP-1 expression is found in several tumors, associated with stemness and tumorigenesis. In colorectal cancer patients, PARP-1 expression correlated with differentiation grade, with a significant association only in tumors with wild-type p53. Additionally, PARP-1 and cancer stem cell markers were positively correlated in these tumors. In vitro studies showed that PARP-1 regulates cancer stem cell phenotype depending on p53 status, with overexpression increasing marker expression and sphere forming ability in wild-type p53 cells, while reducing these features in mutated p53 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Yu Chen, Hui Zeng, Mingming Hou, Yuzhi Qiu
Summary: The study discovered that azurin selectively induces apoptosis and cell cycle arrest in U2OS cells, mediated by P21. This research highlights the potential of azurin as a sensitizer for DDP in the treatment of OS.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Virology
Yi Gong, Tongtong Kong, Jude Juventus Aweya, Hongyu Ma, Yueling Zhang, Shengkang Li
Summary: This study reveals that HUWE1 and TRAF6 can serve as E3 ubiquitin ligases for p53 in mud crabs, providing evidence for the diversity of the p53 ubiquitination regulatory pathway. In addition, it is the first clarification of the immunologic functions and mechanisms of p53 ubiquitination in invertebrates, showing that p53 ubiquitination can affect ROS and apoptosis signals to cope with WSSV infection in mud crabs.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Fanwei Meng, Junfeng Ke, Jinze Li, Changhui Zhao, Jiaqing Yan, Liping Wang
Summary: Cerebral ischemia-reperfusion injury (CIRI) is a brain injury that occurs during thrombolytic therapy for acute ischemic stroke and has a significant impact on human health. DhHP-3, a peroxidase-mimicking enzyme, has shown strong antioxidant properties in vitro. This study established in vitro and in vivo models to investigate the beneficial effects of DhHP-3 on CIRI. The results demonstrated that DhHP-3 reduced reactive oxygen species, suppressed apoptosis, and attenuated the DNA damage response in cells and animal models. In conclusion, DhHP-3 inhibits CIRI by suppressing ROS-induced apoptosis.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tae Ho Hong, M. T. Jeena, Ok-Hee Kim, Kee-Hwan Kim, Ho Joong Choi, Kyung Hee Lee, Ha-Eun Hong, Ja-Hyoung Ryu, Say-June Kim
Summary: The study demonstrates that Mito-FF exhibits significant anticancer effects against sorafenib-resistant Huh7-R cells by promoting cell apoptosis and inhibiting cell proliferation. These effects are achieved through the upregulation of mitochondrial ROS levels.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ra Ham Lee, Jae-Don Oh, Jae Sam Hwang, Hak-Kyo Lee, Donghyun Shin
Summary: This study identified the insect-derived peptide PCC-1 as a potential anticancer agent for melanoma, demonstrating its effects on antiproliferation, apoptosis, and cell cycle arrest in melanoma cells. The research also revealed a novel anticancer mechanism through the regulation of the transcription factor Sp1 protein by insect-derived peptides.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Brandon Hogstad, Marie-Luise Berres, Rikhia Chakraborty, Jun Tang, Camille Bigenwald, Madhavika Serasinghe, Karen Phaik Har Lim, Howard Lin, Tsz-Kwong Man, Romain Remark, Samantha Baxter, Veronika Kana, Stefan Jordan, Zoi Karoulia, Wing-hong Kwan, Marylene Leboeuf, Elisa Brandt, Helene Salmon, Kenneth McClain, Poulikos Poulikakos, Jerry Chipuk, Willem J. M. Mulder, Carl E. Allen, Miriam Merad
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Endocrinology & Metabolism
Anil Kumar, Liora S. Katz, Anna M. Schulz, Misung Kim, Lee B. Honig, Lucy Li, Bennett Davenport, Dirk Homann, Adolfo Garcia-Ocana, Mark A. Herman, Cole M. Haynes, Jerry E. Chipuk, Donald K. Scott
Editorial Material
Cell Biology
Marie Anne O'Donnell, Nicole Infarinato
JOURNAL OF CELL BIOLOGY
(2018)
Article
Oncology
Franco Abbate, Brateil Badal, Karen Mendelson, Iraz T. Aydin, Madhavika N. Serasinghe, Ramiz Iqbal, Jarvier N. Mohammed, Alexander Solovyov, Benjamin D. Greenbaum, Jerry E. Chipuk, Julide T. Celebi
PIGMENT CELL & MELANOMA RESEARCH
(2018)
Article
Cell Biology
Madhavika N. Serasinghe, Jesse D. Gelles, Kent Li, Lauren Zhao, Franco Abbate, Marie Syku, Jarvier N. Mohammed, Brateil Badal, Cuahutlehuanitzin A. Rangel, Kyle L. Hoehn, Julide Tok Celebi, Jerry Edward Chipuk
CELL DEATH & DISEASE
(2018)
Review
Pharmacology & Pharmacy
Camila Rubio-Patino, Andrew Paul Trotta, Jerry Edward Chipuk
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Immunology
Bennett Davenport, Jens Eberlein, Verena van der Heide, Kevin Jhun, Tom T. Nguyen, Francisco Victorino, Andrew Trotta, Jerry Chipuk, Zhengzi Yi, Weijia Zhang, Eric T. Clambey, Donald K. Scott, Dirk Homann
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Jerry Edward Chipuk
Article
Biochemistry & Molecular Biology
Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patino, Jarvier N. Mohammed, Mark P. A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk
Article
Multidisciplinary Sciences
Luis C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky, Pablo Meyer
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Giselle A. Joseph, Margaret Hung, Aviva J. Goel, Mingi Hong, Marysia-Kolbe Rieder, Noam D. Beckmann, Madhavika N. Serasinghe, Jerry E. Chipuk, Parvathi M. Devarakonda, David J. Goldhamer, Paulina Aldana-Hernandez, Jonathan Curtis, Rene L. Jacobs, Robert S. Krauss
Article
Biochemistry & Molecular Biology
Jarvier N. Mohammed, Jesse D. Gelles, Camila Rubio-Patino, Madhavika N. Serasinghe, Andrew P. Trotta, Richard A. Lockshin, Zahra Zakeri, Jerry E. Chipuk
Article
Medicine, Research & Experimental
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
Summary: The research indicates that TNF released by T cells can activate RIPK1-dependent cell death program in target cells, leading to target cell lysis. This phenomenon not only accelerates murine cardiac allograft rejection but also synergizes with anti-PD1 administration to destroy checkpoint blockade-resistant murine melanoma.
Article
Biochemical Research Methods
Jesse D. Gelles, Jarvier N. Mohammed, Yiyang Chen, Tara M. Sebastian, Jerry Edward Chipuk
Summary: This study presents a new method, FLAMBE, for monitoring early activation of BAX and demonstrates its reliability and applicability through investigations on a range of BAX modulators. The study reveals that previously considered "dead" BAX mutants are still responsive to activation, filling a gap in previous research.
CELL REPORTS METHODS
(2022)
Article
Oncology
Jesse D. Gelles, Jerry Edward Chipuk
MOLECULAR & CELLULAR ONCOLOGY
(2020)