Genome instability: Does genetic diversity amplification drive tumorigenesis?

Mammalian chromosomes containcis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes

(2012) Mathew J. Thayer   BIOESSAYS

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Mechanisms for recurrent and complex human genomic rearrangements

(2012) Pengfei Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

BRCA2 Fine-Tunes the Spindle Assembly Checkpoint through Reinforcement of BubR1 Acetylation

(2012) Eunhee Choi et al.   DEVELOPMENTAL CELL

The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability

(2012) R. Steinacher et al.   GENES & DEVELOPMENT

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Replication timing and its emergence from stochastic processes

(2012) John Bechhoefer et al.   TRENDS IN GENETICS

Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients

(2011) F. Magrangeas et al.   BLOOD

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

DNA glycosylases: in DNA repair and beyond

(2011) Angelika L. Jacobs et al.   CHROMOSOMA

The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality

(2011) Hanspeter Naegeli et al.   DNA REPAIR

On the sequence-directed nature of human gene mutation: The role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease

(2011) David N. Cooper et al.   HUMAN MUTATION

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

p53: Guardian of ploidy

(2011) Yael Aylon et al.   Molecular Oncology

Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations

(2011) Jian-Min Chen et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes

(2011) Subhajyoti De et al.   NATURE BIOTECHNOLOGY

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

The consequences of structural genomic alterations in humans: Genomic Disorders, genomic instability and cancer

(2011) Rita Colnaghi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

How dormant origins promote complete genome replication

(2011) J. Julian Blow et al.   TRENDS IN BIOCHEMICAL SCIENCES

pRB, a tumor suppressor with a stabilizing presence

(2011) Amity L. Manning et al.   TRENDS IN CELL BIOLOGY

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

CINister thoughts: Figure 1

(2010) Floris Foijer   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Centriole duplication: analogue control in a digital age

(2010) Greenfield Sluder et al.   CELL BIOLOGY INTERNATIONAL

Cohesin is needed for bipolar mitosis in human cells

(2010) Laura A. Díaz-Martínez et al.   CELL CYCLE

Determinants of Rad21 localization at the centrosome in human cells

(2010) Juan F. Giménez-Abián et al.   CELL CYCLE

Rad21 is required for centrosome integrity in human cells independently of its role in chromosome cohesion

(2010) Nicole A. Beauchene et al.   CELL CYCLE

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Proteomic and functional analysis of the mitotic Drosophila centrosome

(2010) Hannah Müller et al.   EMBO JOURNAL

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

(2010) Rocio Sotillo et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA replication fidelity and cancer

(2010) Bradley D. Preston et al.   SEMINARS IN CANCER BIOLOGY

Mutator phenotypes due to DNA replication infidelity

(2010) Mercedes E. Arana et al.   SEMINARS IN CANCER BIOLOGY

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

The role of aneuploidy in promoting and suppressing tumors: Figure 1.

(2009) Beth A.A. Weaver et al.   JOURNAL OF CELL BIOLOGY

Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement

(2009) Akito Nakamura et al.   JOURNAL OF CELL BIOLOGY

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

Cohesin and Human Disease

(2008) Jinglan Liu et al.   Annual Review of Genomics and Human Genetics

Kinetochore structure and spindle assembly checkpoint signaling in the budding yeast, Saccharomyces Cerevisiae

(2008) Duncan et al.   Frontiers in Bioscience-Landmark

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Combined BubR1 protein down-regulation andRASSF1Ahypermethylation in Wilms tumors with diverse cytogenetic changes

(2008) Masayuki Haruta et al.   MOLECULAR CARCINOGENESIS

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

(2008) Peter J Campbell et al.   NATURE GENETICS

Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome

(2008) A. Shlien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE