Article
Multidisciplinary Sciences
Musarat Amina, Ramesa Shafi Bhat, Abeer M. Al-Dbass, Nawal M. Musayeib, Rania Fahmy, Leen Alhadlaq, Afaf El-Ansary
Summary: In this study, we found that Moringa oleifera seed extract has a protective effect against glutamate-induced DNA damage in RGCs, potentially increasing the cell survival rate without affecting DNA integrity. The seed extract is rich in phytochemicals and demonstrates neuroprotective effects, suggesting it may help prevent the development of neurodegenerative disorders.
Article
Biochemistry & Molecular Biology
Yvonne Kohl, Nicola William, Elisabeth Elje, Nadine Backes, Mario Rothbauer, Annamaria Srancikova, Elise Runden-Pran, Naouale El Yamani, Rafi Korenstein, Lea Madi, Alexander Barbul, Katarina Kozics, Monika Sramkova, Karen Steenson, Alena Gabelova, Peter Ertl, Maria Dusinska, Andrew Nelson
Summary: This study compared the performance and output of an electrochemical phospholipid membrane platform with cell-based toxicity testing methods using various toxicants. The results showed that the membrane sensor and cell-based systems provided similar toxicity rankings when acute cell viability was the endpoint. However, a different toxicity ranking was observed when colony forming efficiency or DNA damage was used as the endpoint. The study demonstrates the potential of electrochemical membrane-based sensors for rapid preliminary toxicity screening.
BIOELECTROCHEMISTRY
(2023)
Article
Biophysics
Joana B. Ferrado, Adrian A. Perez, Malen Menegon, Victoria A. Vaillard, Fatima Gasser, Maria E. Baravalle, Hugo H. Ortega, Santiago E. Vaillard, Liliana G. Santiago
Summary: In this study, self-assembled bovine serum albumin nanoparticles loaded with genistein were PEGylated to avoid possible immunogenic reactions and rapid clearance from the bloodstream. The PEGylation process increased the particle size of the nanoparticles and improved their biological properties, reducing cytotoxicity and genotoxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Lilia Patricia Bustamante-Montes, Keila Isaac-Olive, Rafael Valencia-Quintana, Ninfa Ramirez-Duran
Summary: The genotoxic potential of mercury and its derivatives remains controversial, with organic mercury compounds being more toxic than inorganic and elemental ones but all still posing a potential risk. There is not sufficient evidence for mercury to be classified as a human carcinogen. Studies have shown that inorganic mercury compounds such as mercury chloride and mercury nitrate, and organic compounds like methylmercury and thimerosal, are widely studied in populations with accidental, occupational, or iatrogenic exposure.
Article
Chemistry, Multidisciplinary
Sumera Zaib, Urooj Y. Virk, Javed Wattoo, Hamid S. Shah, Nasser S. Awwad, Hala A. Ibrahium, Imtiaz Khan
Summary: Phytochemicals extracted from carrots possess anticancer properties, exhibiting both antiproliferative and proapoptotic effects on cervical cancer cells.
Article
Environmental Sciences
Milda Babonaite, Matas Cepulis, Jurate Kazlauskaite, Juozas Rimantas Lazutka
Summary: According to PlasticEurope, global plastics production reached 390.7 million tons in 2021. Unfortunately, a large portion of these plastics end up as waste in the ocean or on land due to their non-biodegradable nature. This study focused on evaluating the internalization rates, cytotoxicity, and genotoxicity of polystyrene nanoparticles (PS-NPs) in human peripheral blood mononuclear cells (PBMCs) in vitro. The results showed that while PS-NPs did not have a cytotoxic effect on PBMCs, they did induce primary DNA damage and micronucleated cells, indicating their genotoxic potential.
Article
Food Science & Technology
Julia Buchmueller, Anne-Margarethe Enge, Antonia Peters, Johanna Ebmeyer, Jan-Heiner Kuepper, Bernd Schaefer, Albert Braeuning, Stefanie Hessel-Pras
Summary: This study investigated the genotoxic profile of varying degrees of esterification of unsaturated pyrrolizidine alkaloids (PAs). The results revealed that diester-type PAs had more pronounced effects than monoester-type PAs, including cytotoxicity, DNA damage, and cell cycle perturbation. Additionally, in vitro experiments showed that lasiocarpine had aneugenic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lina Hudhud, David R. Chisholm, Andrew Whiting, Anita Steib, Krisztina Pohoczky, Angela Kecskes, Eva Szoke, Zsuzsanna Helyes
Summary: We investigated the effects of stable diphenylacetylene-based analogues of all-trans-retinoic acid (ATRA) on cell viability and genotoxicity. These analogues demonstrated variation in cytotoxic activity, with some showing stronger genotoxicity at higher concentrations. Although these compounds exhibited retinoid receptor-independent genotoxicity, further research is needed to understand their molecular mechanisms and complex biological functions.
Article
Fisheries
Javier Mayor, Alberto Cuesta, Cristobal Espinosa-Ruiz, M. Angeles Esteban
Summary: This study investigated the effects of Astaxanthin (AX) on various fish pathogenic bacteria and fish cell lines. The results showed that AX had different effects on different bacteria and cell lines, providing valuable insights into the mechanism of action of AX in aquaculture.
AQUACULTURE REPORTS
(2023)
Article
Chemistry, Physical
Mrugesh Trivedi, Chirag N. Patel, Druma Vaidya, Nirav P. Raval, Manish Kumar
Summary: The study aimed to investigate the effects of BPA on DNA damage and cytotoxicity in HepG2 cell line at concentrations ranging from 0.02-200μg/mL, as well as the ameliorating effect of GA (10-50μg/mL). The results showed that BPA was not genotoxic and cytotoxic at low dose exposure (0.02μg/mL), but induced significant DNA damage and cytotoxicity in a dose-dependent manner at concentrations of 2-200μg/mL. However, the addition of GA (10-50μg/mL) with BPA (200μg/mL) inhibited DNA damage and cytotoxicity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Environmental Sciences
Joao Luiz Coelho Ribas, Stefani Rossi, Gabrieli Limberger Galvan, William de Almeida, Marta Margarete Cestari, Helena C. Silva de Assis, Aleksander R. Zampronio
Summary: This study investigated the effects of Pb and TiO2 NPs alone or in combination on the macrophages of freshwater fish, naive or stimulated with LPS. Both Pb and TiO2 NPs reduced cell viability, but higher concentrations of NPs restored it. NO production was decreased by both substances, but the combination of Pb and TiO2 NPs prevented this reduction only at lower concentrations. Neither substance caused DNA fragmentation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Plant Sciences
Ji-Hye Jang, Chang-Seob Seo, Hyekyung Ha, Su-Cheol Han, Mee-Young Lee, Hyeun-Kyoo Shin
Summary: Asiasari Radix et Rhizoma (ARE) is a traditional herbal medicine known for its pain-relieving properties, but recent studies suggest that it may have genotoxic effects, particularly evident in chromosomal aberration and Ames tests. Further research is needed to fully understand the potential risks associated with the use of this herbal medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Vehbi Atahan Togay, Gulcin Yavuz Turel, Dilek Asci celik, Meltem ozgocmen, Eda Evgen Tuluceoglu, Ismail Sen, Yusuf Ayvaz
Summary: This study found that cyprodinil and thiacloprid exposure can lead to increased DNA damage risk in zebrafish, as demonstrated by comet assay. These pesticides were identified as genotoxic agents that require further investigation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Francisco Laerte Lopes da Silva, Amanda Souza Scotti, Ana Leticia Hilario Garcia, Maria Luiza Brodt Lemes, Ivana Grivicich, Gabriela Mendonca dos Reis, Johnny Ferraz Dias, Fernanda Briao Menezes Boaretto, Jaqueline Nascimento Picada, Juliana da Silva, Alexandre de Barros Falcao Ferraz
Summary: The present study aimed to determine the chemical composition, cytotoxic, genotoxic, mutagenic potential, and antioxidant activity of an aqueous extract of Aloysia gratissima leaves. Results showed that the extract contained terpenoids, flavonoids, and phenolic acids, and exhibited cytotoxic activities against various cancer cells, as well as DNA damage and mutations. Therefore, caution should be exercised when using this plant preparation, despite its pharmacological potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Toxicology
Marzieh Farahani-Zangaraki, Azade Taheri, Mahmoud Etebari
Summary: Research shows that carvedilol can reduce insulin-induced DNA damage by decreasing ROS production. Treating HUVEC cells in pre-treatment condition with amorphous-CRV and niosome-CRV significantly reduces insulin-induced DNA damage.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)