Targeting Focal Adhesion Kinase in Fibrotic Diseases

Clinical Importance and Potential Use of Small Molecule Inhibitors of Focal Adhesion Kinase

(2012) Alexander Schultze et al.   Anti-Cancer Agents in Medicinal Chemistry

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis

(2011) Jeffrey C. Horowitz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

(2010) David Lagares et al.   ARTHRITIS AND RHEUMATISM

The Role of Endothelin-1 in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2010) Jeffrey J. Swigris et al.   BIODRUGS

Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts

(2010) Guo-qiang Cai et al.   EXPERIMENTAL CELL RESEARCH

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

(2010) Alexander Schultze et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Expression of integrin  1 by fibroblasts is required for tissue repair in vivo

(2010) S. Liu et al.   JOURNAL OF CELL SCIENCE

Focal adhesion kinase mediates TGF-β1-induced renal tubular epithelial-to-mesenchymal transition in vitro

(2010) Bingqing Deng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Extracellular matrix-induced transforming growth factor-β receptor signaling dynamics

(2010) N Garamszegi et al.   ONCOGENE

Specific shRNA targeting ofFAKinfluenced collagen metabolism in rat hepatic stellate cells

(2010) Zhi-Na Dun   WORLD JOURNAL OF GASTROENTEROLOGY

The dual kinase complex FAK-Src as a promising therapeutic target in cancer

(2010) Victoria Bolós   OncoTargets and Therapy

Requirement of transforming growth factor β-activated kinase 1 for transforming growth factor β-induced α-smooth muscle actin expression and extracellular matrix contraction in fibroblasts

(2009) Xu Shi-Wen et al.   ARTHRITIS AND RHEUMATISM

Loss of β1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model

(2009) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Focal adhesion kinase signaling in cardiac hypertrophy and failure

(2009) K.G. Franchini et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex

(2009) Ana Paula Dalla Costa et al.   CARDIOVASCULAR RESEARCH

FAK, PIP5KI  and gelsolin cooperatively mediate force-induced expression of  -smooth muscle actin

(2009) M. W. C. Chan et al.   JOURNAL OF CELL SCIENCE

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Focal Adhesion Kinase (FAK)-related Non-kinase Inhibits Myofibroblast Differentiation through Differential MAPK Activation in a FAK-dependent Manner

(2008) Qiang Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE