Site-Specific PEGylation of Therapeutic Proteins via Optimization of Both Accessible Reactive Amino Acid Residues and PEG Derivatives

Uricases as Therapeutic Agents to Treat Refractory Gout: Current States and Future Directions

(2012) Xiaolan Yang et al.   DRUG DEVELOPMENT RESEARCH

Recombinant Protein Hydrazides: Application to Site-Specific Protein PEGylation

(2011) Jennifer Thom et al.   BIOCONJUGATE CHEMISTRY

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

(2011) Felix F. Schumacher et al.   BIOCONJUGATE CHEMISTRY

Designing and Engineering of a Site-specific Incorporation of a Keto Group in Uricase

(2011) Zhengzhi Fang et al.   Chemical Biology & Drug Design

Development of a novel DDS for site-specific PEGylated proteins

(2011) Yasuo Yoshioka et al.   Chemistry Central Journal

Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation

(2011) Shogo Narimatsu et al.   CYTOKINE

N-terminal specificity of PEGylation of human bone morphogenetic protein-2 at acidic pH

(2011) Junli Hu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A new method to increase selectivity of transglutaminase mediated PEGylation of salmon calcitonin and human growth hormone

(2011) Anna Mero et al.   JOURNAL OF CONTROLLED RELEASE

Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity

(2011) Andrew J. Keefe et al.   Nature Chemistry

A double antigen bridging immunogenicity ELISA for the detection of antibodies to polyethylene glycol polymers

(2011) Yijuan Liu et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor

(2010) Tomohiro Morishige et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies

(2010) Yu-Cheng Su et al.   BIOCONJUGATE CHEMISTRY

Prediction of Immunogenicity of Therapeutic Proteins

(2010) Christine J. Bryson et al.   BIODRUGS

Effects of Modification of Amino Groups with Poly(Ethylene Glycol) on a Recombinant Uricase fromBacillusfastidiosus

(2010) Chun ZHANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

Pegloticase

(2010) Naomi Schlesinger et al.   NATURE REVIEWS DRUG DISCOVERY

Product development issues for PEGylated proteins

(2010) Robert W. Payne et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

(2010) Masako Ichihara et al.   Pharmaceutics

PEG conjugates in clinical development or use as anticancer agents: An overview

(2009) Gianfranco Pasut et al.   ADVANCED DRUG DELIVERY REVIEWS

Expression, Purification, and C-terminal Site-Specific PEGylation of Cysteine-Mutated Glucagon-Like Peptide-1

(2009) Mingming Gao et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using a phage display system

(2009) Yasuo Yoshioka et al.   BIOMATERIALS

Expanding the Genetic Code for Biological Studies

(2009) Qian Wang et al.   CHEMISTRY & BIOLOGY

Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor

(2009) Carlo Maullu et al.   FEBS Journal

Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility

(2009) Ahmed Besheer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Incorporation of unnatural amino acids for synthetic biology

(2009) Natalya Voloshchuk et al.   Molecular BioSystems

Lactoferrin Conjugated with 40-kDa Branched Poly(ethylene Glycol) Has an Improved Circulating Half-Life

(2009) Yasuhiro Nojima et al.   PHARMACEUTICAL RESEARCH

The Impact of PEGylation on Biological Therapies

(2008) Francesco M Veronese et al.   BIODRUGS

Structural and Functional Roles of the Conserved Cysteine Residues of the Redox-regulated Import Receptor Mia40 in the Intermembrane Space of Mitochondria

(2008) Nadia Terziyska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase

(2007) Angelo Fontana et al.   ADVANCED DRUG DELIVERY REVIEWS

PEG-uricase in the management of treatment-resistant gout and hyperuricemia

(2007) Merry R. Sherman et al.   ADVANCED DRUG DELIVERY REVIEWS

Disulfide bridge based PEGylation of proteins

(2007) Steve Brocchini et al.   ADVANCED DRUG DELIVERY REVIEWS