New Strategies for the Development of H5N1 Subtype Influenza Vaccines

Wide Prevalence of Heterosubtypic Broadly Neutralizing Human Anti-Influenza A Antibodies

(2011) J. Sui et al.   CLINICAL INFECTIOUS DISEASES

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vesicular Stomatitis Virus-Based H5N1 Avian Influenza Vaccines Induce Potent Cross-Clade Neutralizing Antibodies in Rhesus Macaques

(2011) J. A. Schwartz et al.   JOURNAL OF VIROLOGY

Cell-culture-derived influenza vaccine production

(2011) W Paul Glezen   LANCET

Efficacy, safety, and immunogenicity of a Vero-cell-culture-derived trivalent influenza vaccine: a multicentre, double-blind, randomised, placebo-controlled trial

(2011) P Noel Barrett et al.   LANCET

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Influenza Virus-Like Particles Containing M2 Induce Broadly Cross Protective Immunity

(2011) Jae-Min Song et al.   PLoS One

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

(2011) S. Khurana et al.   Science Translational Medicine

An M2 cytoplasmic tail mutant as a live attenuated influenza vaccine against pandemic (H1N1) 2009 influenza virus

(2011) Yasuko Hatta et al.   VACCINE

Cellular immune response in the presence of protective antibody levels correlates with protection against 1918 influenza in ferrets

(2011) Stéphane Pillet et al.   VACCINE

Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles

(2010) Jae-Min Song et al.   ANTIVIRAL RESEARCH

MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation

(2010) Yvonne Genzel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Validation of the safety of MDCK cells as a substrate for the production of a cell-derived influenza vaccine

(2010) David Onions et al.   BIOLOGICALS

Microneedle Delivery of H5N1 Influenza Virus-Like Particles to the Skin Induces Long-Lasting B- and T-Cell Responses in Mice

(2010) J.-M. Song et al.   Clinical and Vaccine Immunology

Vaccines against Seasonal and Pandemic Influenza and the Implications of Changes in Substrates for Virus Production

(2010) Philip D. Minor   CLINICAL INFECTIOUS DISEASES

The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults

(2010) Christopher S. Ambrose et al.   Influenza and Other Respiratory Viruses

Potent Vesicular Stomatitis Virus-Based Avian Influenza Vaccines Provide Long-Term Sterilizing Immunity against Heterologous Challenge

(2010) J. A. Schwartz et al.   JOURNAL OF VIROLOGY

Tyrosines in the Influenza A Virus M2 Protein Cytoplasmic Tail Are Critical for Production of Infectious Virus Particles

(2010) M. L. Grantham et al.   JOURNAL OF VIROLOGY

Gastrointestinal Delivery of Baculovirus Displaying Influenza Virus Hemagglutinin Protects Mice against Heterologous H5N1 Infection

(2010) M. Prabakaran et al.   JOURNAL OF VIROLOGY

Intradermal Vaccination with Influenza Virus-Like Particles by Using Microneedles Induces Protection Superior to That with Intramuscular Immunization

(2010) F.-S. Quan et al.   JOURNAL OF VIROLOGY

Neutralizing Epitopes of Influenza Virus Hemagglutinin: Target for the Development of a Universal Vaccine against H5N1 Lineages

(2010) M. Prabakaran et al.   JOURNAL OF VIROLOGY

Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret

(2010) Srinivas S. Rao et al.   PLoS One

Intranasal Immunization with Influenza VLPs Incorporating Membrane-Anchored Flagellin Induces Strong Heterosubtypic Protection

(2010) Bao-Zhong Wang et al.   PLoS One

Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus

(2010) J.-M. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Production and antigenic properties of influenza virus from suspension MDCK-siat7e cells in a bench-scale bioreactor

(2010) Chia Chu et al.   VACCINE

NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets

(2010) Bin Zhou et al.   VACCINE

Comparison of egg and high yielding MDCK cell-derived live attenuated influenza virus for commercial production of trivalent influenza vaccine: In vitro cell susceptibility and influenza virus replication kinetics in permissive and semi-permissive cells

(2010) Althaf I. Hussain et al.   VACCINE

Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus

(2010) Peter Pushko et al.   VACCINE

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor

(2010) V. Lohr et al.   VACCINE

Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles

(2010) Jae-Min Song et al.   VIROLOGY

Comparative immunogenicity of recombinant adenovirus-vectored vaccines expressing different forms of hemagglutinin (HA) proteins from the H5 serotype of influenza A viruses in mice

(2010) Xiangjing Hu et al.   VIRUS RESEARCH

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins

(2010) Taia T. Wang et al.   PLoS Pathogens

FluBlok, a next generation influenza vaccine manufactured in insect cells

(2009) Manon M.J. Cox et al.   BIOLOGICALS

Prepandemic H5N1 influenza vaccine adjuvanted with AS03: a review of the pre-clinical and clinical data

(2009) Geert Leroux-Roels   EXPERT OPINION ON BIOLOGICAL THERAPY

Trivalent MDCK cell culture-derived influenza vaccine Optaflu®(Novartis Vaccines)

(2009) Alexander Doroshenko et al.   Expert Review of Vaccines

Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines

(2009) P Noel Barrett et al.   Expert Review of Vaccines

A Novel Type of Influenza Vaccine: Safety and Immunogenicity of Replication‐Deficient Influenza Virus Created by Deletion of the Interferon Antagonist NS1

(2009) Volker Wacheck et al.   JOURNAL OF INFECTIOUS DISEASES

Enhanced Memory Responses to Seasonal H1N1 Influenza Vaccination of the Skin with the Use of Vaccine‐Coated Microneedles

(2009) Yeu‐Chun Kim et al.   JOURNAL OF INFECTIOUS DISEASES

Kinetics of Immune Responses to Influenza Virus-Like Particles and Dose-Dependence of Protection with a Single Vaccination

(2009) F. S. Quan et al.   JOURNAL OF VIROLOGY

Electroporation of Synthetic DNA Antigens Offers Protection in Nonhuman Primates Challenged with Highly Pathogenic Avian Influenza Virus

(2009) D. J. Laddy et al.   JOURNAL OF VIROLOGY

Influenza A Virus Lacking M2 Protein as a Live Attenuated Vaccine

(2009) S. Watanabe et al.   JOURNAL OF VIROLOGY

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

MVA-Based H5N1 Vaccine Affords Cross-Clade Protection in Mice against Influenza A/H5N1 Viruses at Low Doses and after Single Immunization

(2009) Joost H. C. M. Kreijtz et al.   PLoS One

Rewiring the RNAs of influenza virus to prevent reassortment

(2009) Q. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production

(2009) C. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge

(2009) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses

(2009) Graeme E. Price et al.   VACCINE

Current challenges in implementing cell-derived influenza vaccines: Implications for production and regulation, July 2007, NIBSC, Potters Bar, UK

(2009) Philip D. Minor et al.   VACCINE

Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults

(2009) Ruth A. Karron et al.   VACCINE

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

(2009) Suzanne Jones et al.   VACCINE

Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: An open non-randomised extension of a double-blind randomised primary study

(2009) Isabel Leroux-Roels et al.   VACCINE

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus

(2009) Amorsolo L. Suguitan et al.   VIROLOGY

Influenza vaccines based on virus-like particles

(2009) Sang-Moo Kang et al.   VIRUS RESEARCH

Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates

(2009) Shufang Fan et al.   PLoS Pathogens

Influenza A viruses with truncated NS1 as modified live virus vaccines: Pilot studies of safety and efficacy in horses

(2008) T. M. Chambers et al.   EQUINE VETERINARY JOURNAL

Pandemic H5N1 influenza vaccine development: an update

(2008) Hana M El Sahly et al.   Expert Review of Vaccines

FluBlok, a recombinant hemagglutinin influenza vaccine

(2008) Manon M.J. Cox et al.   Influenza and Other Respiratory Viruses

Recombinant Modified Vaccinia Virus Ankara Expressing the Hemagglutinin Gene Confers Protection against Homologous and Heterologous H5N1 Influenza Virus Infections in Macaques

(2008) J. H. C. M. Kreijtz et al.   JOURNAL OF INFECTIOUS DISEASES

Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 Highly Pathogenic Avian Influenza

(2008) J. Steel et al.   JOURNAL OF VIROLOGY

A Clinical Trial of a Whole-Virus H5N1 Vaccine Derived from Cell Culture

(2008) Hartmut J. Ehrlich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

(2008) Dominick J. Laddy et al.   PLoS One

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies

(2008) A. K. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice

(2008) Andreas Wack et al.   VACCINE

Protective immunity against influenza H5N1 virus challenge in mice by intranasal co-administration of baculovirus surface-displayed HA and recombinant CTB as an adjuvant

(2008) Mookkan Prabakaran et al.   VIROLOGY

Evolutionary Dynamics and Emergence of Panzootic H5N1 Influenza Viruses

(2008) Dhanasekaran Vijaykrishna et al.   PLoS Pathogens

A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus

(2007) John Steel et al.   VACCINE