Article
Environmental Sciences
Ricardo Alves Bernardo, Jean Carlos Pereira Sousa, Matheus Gallimberti, Fernando Barbosa Junior, Boniek Gontijo Vaz, Andrea Rodrigues Chaves
Summary: Concerns over human health risks due to the use of bisphenol A in thermal papers have led to its replacement by bisphenol S. Analyzing bisphenols typically involves laborious and time-consuming steps, but a new paper spray ionization mass spectrometry (PSI-MS) method offers a faster and efficient alternative. The study found that bisphenol S concentrations in BPA-free thermal papers ranged from 1.36 to 6.77 mu g g(-1), while BPA concentrations in all samples of thermal paper ranged from 6.56 to 16.4 mu g g(-1).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dongning Song, Song Yuan, Caiyu Zhang, Lin Luan, Yang Liu, Qingsheng Zhang
Summary: Estrogens found in personal care products have negative effects on consumers. The conventional methods for detecting these compounds, such as HPLC and LC-MS, require time-consuming sample pretreatment and analysis. However, the paper-spray ionization mass spectrometry (PSI-MS) method developed in this study allows for quick and efficient determination of estradiol, estriol, and ethinyloestradiol in cosmetics. This method, which involves chemical derivatization, showed excellent linearity, high recovery rates, and significantly improved limits of detection compared to non-derivative PSI-MS techniques.
Article
Biochemistry & Molecular Biology
Sung Jun An, Youngjoo Kal, Minjoo Jeong, Sumin Kang, Byeongho Kwak, Hyunsoo Kim, Shihyeon Ryu, Sangwon Cha
Summary: In this study, droplet PSI MS utilizing Teslin(R) as a substrate was developed for protein analysis, demonstrating superior sensitivity compared to conventional PSI MS. The method also allowed real-time observation of protein alterations.
Article
Chemistry, Multidisciplinary
Wangmin Hu, Tianyi Li, Yulei Yang, Shanshan Jia, Mei Zhang
Summary: This study presents a derivative-free and ion mobility-free paper spray tandem mass spectrometry method for rapid analysis of mono- and disaccharides. By calculating the R-value, the species and conformation of simple saccharides can be easily differentiated. The method has potential applications in clinical sample analysis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Food Science & Technology
Wejdan T. Alsaggaf
Summary: This study presents a simple, rapid, and accurate paper spray ionization mass spectrometry method for trace determination of lutein in matrices of different complexities. The method was successfully applied for trace determination of lutein residues in fresh and commercial foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Thi Minh Hoa Nguyen, Woo-Young Song, Tae-Young Kim
Summary: This study systematically evaluated the factors affecting the ionization efficiency of paper spray ionization (PSI) and classified the observed paper spray plume into three modes. The rim-jet mode exhibited the highest ionization efficiency among the three modes. The charge density of the droplets generated by paper spray, influenced by the electric field and solvent supply rate, was found to be the main parameter determining the spray mode.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemical Research Methods
Chaozi Liu, Yuze Li, Caiqiao Xiong, Zongxiu Nie
Summary: The capillary-paper spray ion source allows for sample separation and enables rapid and sensitive analysis of biofluids. By absorbing proteins and macromolecules, it reduces matrix effects and improves the detection of small molecules. Compared to traditional methods, the CPS method shows improved spray stability, prolonged analysis duration, and enhanced signal intensities, indicating its potential for clinical use.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ping Guo, Ke Min, Wei Luo, Si Huang, Zihui Yang, Ming Ma, Shubin Liu, Zhengfa Fang, Bo Chen, Han Zuilhof
Summary: Ambient ionization of glycans can be achieved efficiently by spraying from a paper surface impregnated with alkali metal salt. This method allows for the formation of abundant alkali metal adduct ions from monosaccharides, oligosaccharides, and ring glycans, resulting in simple and clean mass spectra. The approach is specific for glycans and has been successfully applied in the determination of glycans and glycoconjugates in various biological matrices.
Article
Chemistry, Analytical
Vincen Wu, Jocelyn Tillner, Emrys Jones, James S. McKenzie, Dipa Gurung, Anna Mroz, Liam Poynter, Daniel Simon, Cristina Grau, Xavier Altafaj, Marc-Emmanuel Dumas, Ian Gilmore, Josephine Bunch, Zoltan Takats
Summary: This study examines the suitability of desorption electro-flow focusing ionization (DEFFI) for mass spectrometry imaging (MSI) of biological tissue, comparing its performance to the traditional desorption electrospray ionization (DESI). The flow focusing mechanism in DESI offers advantages such as a rotationally symmetric electrospray jet, higher intensity, controllable parameters, and better portability. The optimized parameters for DEFFI result in similar images to DESI but with better sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Youngju Kal, Sangwon Cha
Summary: Paper spray ionization (PSI) is an extractive ambient ionization technique for mass spectrometry, which can achieve the separation and detection of lipid mixtures. The study found that differential transport of lipid classes occurs during PSI, depending on the polarity of the spraying solvent and the method of application.
Article
Chemistry, Applied
Qiuyu Lin, Jiannan Sun, Yuanchao Wang, Meiying Ye, Heyong Cheng
Summary: A highly sensitive and high-throughput method for aldehyde analysis in food has been developed, which does not require sample pretreatment. This method allows direct quantification of four aldehydes in various food matrices and offers the advantages of simplicity and high efficiency.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Yajun Zheng, Yajie Huang, Qianqian Zuo, Yan Zhang, Yuhua Wu, Zhiping Zhang
Summary: In this study, a portable paper-based electrospray ionization (PPESI) technique was developed by using a piece of triangle paper and adsorbent packed into a modified disposable micropipette tip. The PPESI not only captures the features of paper spray and adsorbent for efficient suppression of sample matrixes, but also prevents rapid evaporation of spray solvent. The performance of PPESI can be optimized by adjusting the type and amount of adsorbent, paper substrate, spray solvent, and applied voltage. Compared to other sources, the PPESI coupled with mass spectrometry (MS) showed improved analytical sensitivity and spray duration.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Marcos Bouza, Norman Ahlmann, Juan F. Garcia-Reyes, Joachim Franzke
Summary: The present study investigated the potential of SALD-FμTP-MS as a rapid analytical technique for direct analysis of surface-deposited samples. Paper was used as the substrate and an infrared hand-held laser was employed for sample desorption. The optimization process involved the use of viscous solvents to enhance desorption and ionization efficiencies. Ethylene glycol (EG) was identified as a suitable solvent, improving sensitivity and substrate stability. The applicability of SALD-FμTP-MS was demonstrated by successfully analyzing food, water, and biological samples, particularly for thermolabile and polarity diverse compounds.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Casey A. Chamberlain, Marguerite Hatch, Timothy J. Garrett
Summary: This study introduces a novel application of PSI-MS for the analysis of bacterial EVs for the first time. The isolation and purification of EVs from bacterial culture supernatant using EV-specific affinity chromatography, characterization through nanoparticle tracking analysis, and identification of EV-derived metabolites, lipids, and peptides through PSI-MS represent a pioneering approach in the field of MS-based EV analysis.
Article
Chemistry, Analytical
Wei Luo, Jiaxin Pan, Bo Chen, Ming Ma
Summary: A paper spray tandem mass spectrometric (PS-MS/MS) method without column separation was developed for the rapid screening of clonidine in dietary supplements. PS-MS/MS provided acceptable performance compared to high-performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS) in terms of limits of detection and quantification, accuracy, and precision. Internal standards including nizatidine, tizanidine, and apraclonidine were investigated to compensate for the ionization suppression of complex plant-based pharmaceutical products.
ANALYTICAL LETTERS
(2023)
Article
Engineering, Environmental
Yuefa Jia, Shiping Li, Haoxuan Ma, Jianzhi Gao, Gangqiang Zhu, Fuchun Zhang, Jun Young Park, Sangwon Cha, Jong-Seong Bae, Chunli Liu
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Chemistry, Analytical
Jinyoung An, Ye-Yeong Kim, Hyun-Deok Cho, Junhee Kim, Ji-Youn Lee, Yeoreum Lee, Eunji Jo, Jaeick Lee, Sangwon Cha, Sang Beom Han
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Multidisciplinary Sciences
Jiwoong Kwon, Jong-Seok Park, Minsu Kang, Soobin Choi, Jumi Park, Gyeong Tae Kim, Changwook Lee, Sangwon Cha, Hyun-Woo Rhee, Sang-Hee Shim
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Soobin Choi, Sangwon Cha
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Junhee Kim, Hyun-Deok Cho, Joon Hyuk Suh, Ji-Youn Lee, Eunyoung Lee, Chang Hwa Jin, Yu Wang, Sangwon Cha, Hosub Im, Sang Beom Han
Article
Chemistry, Analytical
Hyun-Deok Cho, Junghyun Kim, Ji-Youn Lee, Ye-Yeong Kim, Yeoreum Lee, Eunji Jo, Joon Hyuk Suh, Jaeick Lee, Sangwon Cha, Sang Beom Han
Article
Biochemical Research Methods
Hyungjun Kim, Hyunwoo Lee, Daesub Kum, Heungsik Tae, Sangwon Cha, Donghwi Kim, Sunghwan Kim
Summary: This study confirmed the occurrence of corona discharge when using nonpolar solvents and proposed its mechanism. Evaluation of different solvents for analyzing crude oil sensitivity revealed that chlorobenzene is the optimal solvent for PSCI.
JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Chemistry, Organic
Kyuho Moon, Jinsheng Cui, Eunji Kim, Evan Setiawan Riandi, So Hyun Park, Woong Sub Byun, Youngju Kal, Jun Young Park, Sunghoon Hwang, Daniel Shin, Jeongyoon Sun, Ki-Bong Oh, Sangwon Cha, Jongheon Shin, Sang Kook Lee, Yeo Joon Yoon, Dong-Chan Oh
Article
Biochemistry & Molecular Biology
Youngju Kal, Sangwon Cha
Summary: Paper spray ionization (PSI) is an extractive ambient ionization technique for mass spectrometry, which can achieve the separation and detection of lipid mixtures. The study found that differential transport of lipid classes occurs during PSI, depending on the polarity of the spraying solvent and the method of application.
Article
Chemistry, Analytical
Jun Young Park, Sarmila Amatya Shrestha, Sangwon Cha
Summary: The study investigated the feasibility of using reversed-phase liquid chromatography to separate ganglioside isomers, successfully achieving the isomer separation of disialogangliosides and trisialogangliosides for the first time. Crucial factors in the mobile-phase composition, such as the organic modifier acetonitrile and the ammonium salt additive ammonium bicarbonate, were identified to influence the differential retention and mass spectral response of the isomers.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Biochemical Research Methods
Kang Mi Lee, Sang Moon Han, Seunghwa Lee, Tae Young Jeong, Ho Jun Kim, Hophil Min, Ki Hun Kim, Sangwon Cha, Won Keun Oh, Jaeick Lee
Summary: A fluoride-assisted LC-MS/MS method combined with direct injection was developed for propofol determination, showing good sensitivity, accuracy, and practicality. The method was successfully applied to human urine, allowing the determination of propofol and its metabolites over 48 hours with sufficient sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Review
Chemistry, Analytical
Sarmila Amatya Shrestha, Sangwon Cha
Summary: The paper reviews the application of ambient desorption/ionization mass spectrometry in the direct analysis of solid materials, covering various sampling and desorption processes. Real-world analysis cases include pharmaceuticals, food products, forensic analysis, and surface contaminant analysis. ADI techniques provide efficient and simplified methods for direct desorption and ionization of analytes from untreated samples under ambient conditions.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Seunghwa Lee, Kang Mi Lee, Sang Moon Han, Hyeon-Jeong Lee, Changmin Sung, Hophil Min, Hosub Im, Sang Beom Han, Sangwon Cha, Jaeick Lee
Summary: To assess the combined effects of environmental pollutants (EPOLs), a comprehensive analytical method was developed to simultaneously analyze multiple EPOLs. The method overcame technical challenges associated with enzyme hydrolysis, simultaneous extraction, and analysis. The method was validated and showed potential for long-term, large-scale, and data-rich human biomonitoring of EPOLs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sangwon Cha, Gyouwoong Jun, Yougyeong Park, Sung Jun An, Donghoon Lee
Summary: Nanospray desorption electrospray ionization (nano-DESI) was used to analyze the metabolite fingerprints on Hypericum leaves. The intensity changes of key metabolites over time were observed through full mass scan experiments and monitored using selected ion monitoring and pseudo-selected reaction monitoring experiments. The correlation between the time-dependent changes in the metabolite fingerprints and depth-wise metabolite distribution was examined by removing the surface layers of the leaves multiple times.
Article
Biochemical Research Methods
Gwangbin Lee, Sangwon Cha
Summary: Nano-DESI MS has been explored in the forensic chemical analysis of ink directly from handwriting on paper, showing the potential for changing mass spectral profiles over time to reflect the differential distribution of analytes in a vertical direction. The study confirmed the capability of the depth-dependent analysis of nano-DESI MS.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
