Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 119, Issue 6, Pages 718-723Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2014.10.026
Keywords
Carboxymethyl cellulose; Nonwoven sheet; Hemostasis; Blood clotting; Bandage; Biomaterial
Funding
- (PD) from the Japan Society for the Promotion of Science (JSPS) [5621]
- Grants-in-Aid for Scientific Research [26420792, 25893052] Funding Source: KAKEN
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Carboxymethyl cellulose (CMC) is a plant-derived material that has high biocompatibility and water solubility. We developed a CMC nonwoven sheet as a hemostatic agent by carboxymethylating a continuous filament cellulose nonwoven sheet. The CMC nonwoven sheet was able to absorb water and dissolve in it. The rates of absorption and dissolution depended on the degree of carboxymethylation. After dissolving in blood, CMC accelerated clot development (possibly owing to the incorporation of CMC into fibrin fibers) and increased the viscosity of the blood, both of which would contribute to the improved blood clotting of an injured surface. In vivo experiments using a rat tail cutting method showed that a CMC nonwoven sheet shortened the bleeding time of the tail when applied to the cut surface. The hemostatic effect of the CMC nonwoven sheet was almost at the same level as a commercial hemostatic bandage. These results suggest that a CMC nonwoven sheet could be used as a novel sheet-type hemostatic agent. (C) 2014, The Society for Biotechnology, Japan. All rights reserved.
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