Journal
JOURNAL OF BIOPHOTONICS
Volume 8, Issue 4, Pages 332-346Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400138
Keywords
Skin; glucose; diffusion; glycation; diabetes mellitus; optical clearing
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Funding
- Britton Chance Center for Biomedical Photonics of Huazhong University of Science and Technology, Wuhan, China
- NSFC-RFBR for International Cooperation [812111313]
- Science Fund for Creative Research Group [61121004]
- Russian Foundation for Basic Research [13-02-91176-GFEH_a]
- Russian Presidential grant [NSh-703.2014.2]
- Tomsk State University Academic D.I. Mendeleev Fund Program
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The aim of this study was to estimate the glucose diffusion coefficients ex vivo in skin of mice with diabetes induced in vivo by alloxan in comparison to non-diabetic mice. The temporal dependences of collimated transmittance of tissue samples immersed in glucose solutions were measured in the VIS-NIR spectral range to quantify the glucose diffusion/permeability coefficients and optical clearing efficiency of mouse skin. The average thickness of intact healthy and diabetic skin was 0.0230.006cm and 0.019 +/- 0.005cm, respectively. Considerable differences in optical and kinetic properties of diabetic and non-diabetic skin were found: clearing efficiency was 1.5-fold better and glucose diffusivity was 2-fold slower for diabetic skin.
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