Article
Food Science & Technology
Hao Ding, Tiecheng Wang, Yuhan Sun, Yuxiang Zhang, Jianping Wei, Rui Cai, Chunfeng Guo, Yahong Yuan, Tianli Yue
Summary: This study used cold plasma to inactivate A. acidoterrestris, a bacterium resistant to heat treatment in fruit juice production. The inactivation efficacy was determined using the plate count method and described using a biphasic model. The study also investigated the effects of food matrix, input power, gas flow rate, and treatment time on inactivation efficacy, and analyzed the inactivation mechanism using scavenging experiments, scanning electron microscopy, and Raman spectra.
Article
Chemistry, Applied
Congdi Shang, Tong Zhang, Junnan Xu, Ning Zhao, Wentao Zhang, Mingtao Fan
Summary: Contaminated Alicyclobacillus has caused significant losses in the beverage industry due to fruit juice spoilage. Understanding the growth and metabolism of Alicyclobacillus acidoterrestris (A. acidoterrestris) is crucial in controlling juice spoilage. This study systematically simulated the growth and metabolism of A. acidoterrestris in both medium and fruit juice. The results revealed that low temperature and strong acidic conditions inhibited the growth and reproduction of A. acidoterrestris, leading to improved quality of commercially available juice supplemented with A. acidoterrestris under low temperature. This research provides valuable insights for exploring additive-free methods to control juice spoilage.
Article
Engineering, Chemical
Jinye Zhang, Sihang Li, Wenjing Wang, Jianfei Pei, Jiawei Zhang, Tianli Yue, Wirote Youravong, Zhenyu Li
Summary: This study successfully developed a food functional microfiltration membrane by multi-stage modification, with polydopamine and nisin microspheres immobilized onto the membrane surface, resulting in enhanced rejection of Alicyclobacillus acidoterrestris and simultaneous exclusion and inactivation. The modified membrane also showed reliable stability under different membrane cleaning procedures.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Food Science & Technology
Zhouli Wang, Yu Tian, Qi Wang, Tianmin Guo, Yahong Yuan, Tianli Yue, Hang Jia, Qian Ge, Zidan Zhao, Rui Cai
Summary: This study investigated the antibacterial activity and underlying mechanism of five preservatives (epsilon-polylysine, propylparaben, monocaprin, octyl gallate, and heptylparaben) against Alicyclobacillus acidoterrestris in apple juice. Results showed that all five preservatives exerted antibacterial activity through a multiple bactericidal mechanism. Monocaprin and octyl gallate had the highest antibacterial activity, with the minimum inhibitory concentration (MIC) values of 22.5 and 6.25 mg/L, respectively. Additionally, the preservatives altered the permeability of the cell membrane, leading to a leakage of intracellular electrolytes. The treatment with epsilon-polylysine, propylparaben, and monocaprin increased the leakage of intracellular protein, while propylparaben and octyl gallate reduced the levels of cellular adenosine triphosphate. Monocaprin and octyl gallate could effectively inactivate the contamination of A. acidoterrestris in apple juice without significant adverse effects on the juice quality.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Food Science & Technology
Hafida Wahia, Long Zhang, Cunshan Zhou, Abdullateef Taiye Mustapha, Olugbenga Abiola Fakayode, Robert Amanor-Atiemoh, Haile Ma, Mokhtar Dabbour
Summary: This study investigated the effectiveness of pulsed multifrequency ultrasound in minimizing Alicyclobacillus acidoterrestris (AAT) spores and vegetative cells. It was found that dual-frequency thermosonication and ultrasonication significantly reduced AAT bacteria, with dual-frequency thermosonication exhibiting higher bactericidal efficacy. Microscopic analysis revealed ultra-structural modifications induced by sonoporation. Fourier-transform infrared spectroscopy showed major changes in the membrane fatty acids and proteins of AAT. The results suggested that pulsed multifrequency ultrasound can be an alternative to mono-frequency ultrasound in the beverage industry.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Yiheng Shi, Lei Zhou, Xiaowei Qu, Tianli Yue, Yahong Yuan
Summary: An effective method for identifying A. acidoterrestris using is-ELISA was developed, which is highly sensitive and specific, suitable for preventing juice spoilage.
Review
Food Science & Technology
Hafida Wahia, Olugbenga Abiola Fakayode, Abdullateef Taiye Mustapha, Cunshan Zhou, Mokhtar Dabbour
Summary: Due to their high-water activity, acidic fruits are prone to spoilage caused by microbial activity. Juice manufacturers are increasingly exploring non-thermal processing methods, such as ultrasonication, to overcome the challenges of mild heat treatment. This article reviews previous research on the inactivation and germination of Alicyclobacillus acidoterrestris in fruit juice using ultrasound and heat.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Yiheng Shi, Yuhan Sun, Xiaowei Qu, Lei Zhou, Zhouli Wang, Zhenpeng Gao, Zhongqiu Hu, Tianli Yue, Yahong Yuan
Summary: In this study, a highly specific monoclonal antibody was developed to detect A. acidoterrestris with great potential for preventing spoilage in the fruit juice industry. The immunoassay platform demonstrated rapid, sensitive, and selective detection capabilities, making it a robust tool for industry applications.
Article
Food Science & Technology
Jun Li, Ning Zhao, Ruoyun Xu, Guomin Li, Huayu Dong, Bingyi Wang, Zhicheng Li, Mingtao Fan, Xinyuan Wei
Summary: This study investigated the antibacterial activity and mechanism of p-coumaric acid against Alicyclobacillus acidoterrestris and its application in apple juice. The results showed that p-coumaric acid had inhibitory effects on both vegetative cells and spores of A. acidoterrestris, damaging cell integrity and disrupting cellular functions. Furthermore, the addition of p-coumaric acid effectively reduced the growth of A. acidoterrestris in apple juice.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Hafida Wahia, Cunshan Zhou, Olugbenga Abiola Fakayode, Robert Amanor-Atiemoh, Long Zhang, Abdullateef Taiye Mustapha, Jin Zhang, Baoguo Xu, Rong Zhang, Haile Ma
Summary: The study showed that the use of multifrequency ultrasound technology can effectively inactivate AAT vegetative cells and spores in orange juice without negatively impacting its quality. Additionally, the production of ROS was found to have an inverse relationship with AAT inactivation.
Article
Microbiology
Xinhong Liang, Cunjian Tu, Yongchao Li, Junliang Sun, Ruixiang Zhao, Junjian Ran, Lingxia Jiao, Junchao Huang, Junrui Li
Summary: This study evaluated the antibacterial activity of quercetin against Alicyclobacillus acidoterrestris and found that quercetin effectively damaged the cell membrane and enhanced the hydrophobicity of the bacterial surface, resulting in significant bactericidal effects. Quercetin also reduced intracellular protein content and impeded ATPase synthesis, leading to bacterial apoptosis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Siqi Zhao, Yanzi Nan, Runyu Yao, Langhong Wang, Xinan Zeng, Rana Muhammad Aadil, Muhammad Asim Shabbir
Summary: The aim of this research was to investigate the antimicrobial characteristics and mechanism of hesperetin against Alicyclobacillus acidoterrestris vegetative cells. The results showed that hesperetin had effective antimicrobial activity on Alicyclobacillus acidoterrestris vegetative cells, leading to significant damage to cell integrity and prevention of cell growth. Transcriptomic analysis revealed that hesperetin affected nitrogen metabolism, amino acid metabolism, nutrient transport, energy metabolism, and flagella motility, providing new insights into its antimicrobial effects and mechanism.
Article
Food Science & Technology
Angela Aparecida Silva, Julio Cesar Polonio, Andressa Domingos Polli, Joao Arthur dos Santos Oliveira, Lilian Capelari Soares, Verci Alves Oliveira Junior, Veronica Elisa Pimenta Vicentini, Arildo Jose Braz Oliveira, Jose Eduardo Goncalves, Regina Aparecida Correia Goncalves, Joao Lucio Azevedo, Joao Alencar Pamphile, Benicio Alves Abreu Filho
Summary: The crude extract of the endophytic fungus F. flavus showed significant antibacterial activity against Alicyclobacillus acidoterrestris, especially when combined with the bacteriocin nisin, exhibiting a synergistic interaction. The extract also demonstrated greater selectivity towards bacterial cells over host cells, with observed interference in the cell membrane of A. acidoterrestris. These results suggest biotechnological potential for the crude extract in the food industry, particularly for the treatment of orange juices by controlling A. acidoterrestris.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ning Zhao, Jie Zhang, Yiman Qi, Junnan Xu, Xinyuan Wei, Mingtao Fan
Summary: The study showed that acid adaptation enhances the resistance of A. acidoterrestris to heat and acid stresses by inducing expression of stress-related genes and promoting spore formation. This coordinated response of maintaining intracellular homeostasis, chaperones and proteases expression, and spore formation has implications for fruit juice processing.
Article
Food Science & Technology
Zhouli Wang, Yunhao Liang, Qi Wang, Hang Jia, Tianli Yue, Yahong Yuan, Zhenpeng Gao, Rui Cai
Summary: This study investigated the mechanism of guaiacol production in A. acidoterrestris through transcriptomic and proteomic approaches, identifying differentially expressed genes and proteins involved in the process. The up-regulation of genes encoding vanillic acid decarboxylase subunits and other transport proteins suggested their roles in guaiacol production. Additionally, changes in gene expression related to metabolic pathways provided new insights into controlling A. acidoterrestris in the fruit juice industry.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Urology & Nephrology
Shinya Ishiko, Naoya Morisada, Atsushi Kondo, Sadayuki Nagai, Yuya Aoto, Eri Okada, Rini Rossanti, Nana Sakakibara, China Nagano, Tomoko Horinouchi, Tomohiko Yamamura, Takeshi Ninchoji, Hiroshi Kaito, Riku Hamada, Yuko Shima, Koichi Nakanishi, Masafumi Matsuo, Kazumoto Iijima, Kandai Nozu
Summary: In the Japanese population, genetically diagnosed ARPKD patients exhibit a wide range of clinical features, including prenatal anomalies, chronic kidney disease, Caroli disease, and hepatic fibrosis. The minigene assay results highlight the importance of functional analysis and challenge the belief that at least one non-truncating mutation is necessary for perinatal survival.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Atsushi Kondo, China Nagano, Shinya Ishiko, Takashi Omori, Yuya Aoto, Rini Rossanti, Nana Sakakibara, Tomoko Horinouchi, Tomohiko Yamamura, Sadayuki Nagai, Eri Okada, Yuko Shima, Koichi Nakanishi, Takeshi Ninchoji, Hiroshi Kaito, Hiroki Takeda, Hiroaki Nagase, Naoya Morisada, Kazumoto Iijima, Kandai Nozu
Summary: Gitelman syndrome is an autosomal recessive disorder with a higher prevalence in the Japanese population than previously thought, and some other ethnicities also show a higher prevalence than expected.
SCIENTIFIC REPORTS
(2021)
Review
Urology & Nephrology
Yurika Tsuji, Tomohiko Yamamura, China Nagano, Tomoko Horinouchi, Nana Sakakibara, Shinya Ishiko, Yuya Aoto, Rini Rossanti, Eri Okada, Eriko Tanaka, Koji Tsugawa, Takayuki Okamoto, Toshihiro Sawai, Yoshinori Araki, Yuko Shima, Koichi Nakanishi, Hiroaki Nagase, Masafumi Matsuo, Kazumoto Iijima, Kandai Nozu
Summary: The study found no significant differences in splicing pattern or renal survival period among reported intron 9 variants causative of Frasier syndrome through in vitro and in vivo experiments as well as a systematic review.
KIDNEY INTERNATIONAL REPORTS
(2021)
Editorial Material
Urology & Nephrology
Saori Nishio, Ken Tsuchiya, Shinya Nakatani, Satoru Muto, Toshio Mochizuki, Haruna Kawano, Kazushige Hanaoka, Sumi Hidaka, Daisuke Ichikawa, Eiji Ishikawa, Kiyotaka Uchiyama, Eri Koshi-Ito, Hiroki Hayashi, Shiho Makabe, Soshiro Ogata, Michihiro Mitobe, Akinari Sekine, Tatsuya Suwabe, Hiroshi Kataoka, Hirayasu Kai, Yoshikatsu Kaneko, Mahiro Kurashige, Koichi Seta, Keiji Shimazu, Taketsugu Hama, Kenichiro Miura, Koichi Nakanishi, Shigeo Horie, Kengo Furuichi, Hirokazu Okada, Ichiei Narita
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Urology & Nephrology
Yuya Aoto, Takeshi Ninchoji, Hiroshi Kaito, Yuko Shima, Junya Fujimura, Naohiro Kamiyoshi, Shingo Ishimori, Koichi Nakanishi, Shogo Minamikawa, Shinya Ishiko, Nana Sakakibara, China Nagano, Tomoko Horinouchi, Tomohiko Yamamura, Sadayuki Nagai, Atsushi Kondo, Yosuke Inaguma, Ryojiro Tanaka, Norishige Yoshikawa, Kazumoto Iijima, Kandai Nozu
Summary: Combination therapy was significantly effective in patients with complicated focal IgAN. The long-term prognosis was good, and the duration of combination therapy for complicated focal IgAN can be decreased to reduce adverse events.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Miki Murakoshi, Koichi Kamei, Masao Ogura, Mai Sato, Taishi Nada, Ryutaro Suzuki, Chikako Kamae, Kentaro Nishi, Toru Kanamori, China Nagano, Kandai Nozu, Koichi Nakanishi, Kazumoto Iijima
Summary: Unilateral nephrectomy during early infancy may be an effective treatment for patients with CNF, allowing for reduction in albumin infusion, prevention of complications, and shorter hospital stays.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Genetics & Heredity
Nana Sakakibara, Kandai Nozu, Tomohiko Yamamura, Tomoko Horinouchi, China Nagano, Ming Juan Ye, Shinya Ishiko, Yuya Aoto, Rini Rossanti, Riku Hamada, Nobuhiko Okamoto, Yuko Shima, Koichi Nakanishi, Masafumi Matsuo, Kazumoto Iijima, Naoya Morisada
Summary: Nephronophthisis is a common kidney disease related to abnormalities in primary cilia. This study identified multiple causative genes for NPHP-RCs using genetic analysis, and found that most patients showed extrarenal manifestations. Comprehensive genetic analysis using NGS is useful for diagnosing patients with NPHP-RCs.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Urology & Nephrology
Kazumoto Iijima, Mayumi Sako, Mari Oba, Seiji Tanaka, Riku Hamada, Tomoyuki Sakai, Yoko Ohwada, Takeshi Ninchoji, Tomohiko Yamamura, Hiroyuki Machida, Yuko Shima, Ryojiro Tanaka, Hiroshi Kaito, Yoshinori Araki, Tamaki Morohashi, Naonori Kumagai, Yoshimitsu Gotoh, Yohei Ikezumi, Takuo Kubota, Koichi Kamei, Naoya Fujita, Yasufumi Ohtsuka, Takayuki Okamoto, Takeshi Yamada, Eriko Tanaka, Masaki Shimizu, Tomoko Horinouchi, Akihide Konishi, Takashi Omori, Koichi Nakanishi, Kenji Ishikura, Shuichi Ito, Hidefumi Nakamura, Kandai Nozu
Summary: Administration of MMF after rituximab may be effective in preventing treatment failure and is well tolerated.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Letter
Oncology
Noboru Hokama, Nobuyuki Hyakuna, Satoru Hamada, Hideo Shiohira, Koichi Nakanishi, Katsunori Nakamura
PEDIATRIC BLOOD & CANCER
(2022)
Letter
Oncology
Hitomi Abe, Satoru Hamada, Hideki Sakiyama, Tokiko Oshiro, Miho Kato, Takeshi Yagi, Takehiro Matsuda, Takeshi Higa, Nobuyuki Hyakuna, Koichi Nakanishi
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pediatrics
Wataru Shimabukuro, Satoru Hamada, Tokiko Oshiro, Shougo Nakada, Nobuyuki Hyakuna, Koichi Nakanishi
Summary: This study reports two cases of elevated serum CysC levels in JMML patients. Despite normal kidney function, it may be associated with tumor burden. It is recommended to determine creatinine or inulin clearance to accurately estimate kidney function when administering anticancer drugs.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Sadayuki Nagai, Tomoko Horinouchi, Takeshi Ninchoji, Atsushi Kondo, Yuya Aoto, Shinya Ishiko, Nana Sakakibara, China Nagano, Tomohiko Yamamura, Hiroshi Kaito, Ryojiro Tanaka, Yuko Shima, Junya Fujimura, Naohiro Kamiyoshi, Shingo Ishimori, Koichi Nakanishi, Norishige Yoshikawa, Kazumoto Iijima, Kandai Nozu
Summary: Japanese childhood HSPN cases with moderate severity have good outcomes without the need for corticosteroids or immunosuppressants when prescribed RAS inhibitor treatment. Even in recurrent cases, abnormal proteinuria is transient, and prognosis is excellent.
PEDIATRIC NEPHROLOGY
(2022)
Article
Urology & Nephrology
Yuya Aoto, Tomoko Horinouchi, Tomohiko Yamamura, Atsushi Kondo, Sadayuki Nagai, Shinya Ishiko, Eri Okada, Rini Rossanti, Nana Sakakibara, China Nagano, Hiroyuki Awano, Hiroaki Nagase, Yuko Shima, Koichi Nakanishi, Masafumi Matsuo, Kazumoto Iijima, Kandai Nozu
Summary: This study revealed that most single-base substitutions at the last nucleotide position of COL4A5 exons result in splicing variants rather than missense variants, leading to more severe phenotypes.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Medicine, General & Internal
Akinari Sekine, Sumi Hidaka, Tomofumi Moriyama, Yasuto Shikida, Keiji Shimazu, Eiji Ishikawa, Kiyotaka Uchiyama, Hiroshi Kataoka, Haruna Kawano, Mahiro Kurashige, Mai Sato, Tatsuya Suwabe, Shinya Nakatani, Tadashi Otsuka, Hirayasu Kai, Kan Katayama, Shiho Makabe, Shun Manabe, Wataru Shimabukuro, Koichi Nakanishi, Saori Nishio, Fumihiko Hattanda, Kazushige Hanaoka, Kenichiro Miura, Hiroki Hayashi, Junichi Hoshino, Ken Tsuchiya, Toshio Mochizuki, Shigeo Horie, Ichiei Narita, Satoru Muto
Summary: Differential diagnosis between ADPKD and other cystic kidney diseases is important, with some diseases easily excluded using clinical information while others require genetic testing or additional information for diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Yasutsugu Chinen, Sadao Nakamura, Kumiko Yanagi, Takuya Kaneshi, Hideki Goya, Tomohide Yoshida, Kazuhito Satou, Tadashi Kaname, Kenji Naritomi, Koichi Nakanishi
Summary: We report a male patient with orofaciodigital (OFD) syndrome type XVI, who had a homozygous variant of TMEM107 gene (p.Phe106del), and tibial dysplasia, which is a crucial feature of OFD syndrome type IV. His family history included two fetuses with anencephaly, with or without cleft lip/palate and polydactyly, but no genetic information was available. Careful attention should be paid to the interpretation of this rare phenotype.
HUMAN GENOME VARIATION
(2022)
