Review
Chemistry, Multidisciplinary
Saiprasad Nunewar, Sanjeev Kumar, Srilakshmi Talakola, Srinivas Nanduri, Vinaykumar Kanchupalli
Summary: Metal carbenes play a crucial role in transition-metal-catalyzed synthetic transfer reactions. Meanwhile, C-H functionalizations catalyzed by Co(III), Rh(III) & Ir(III) have been well established. The combination of C-H activation and carbene migratory insertion has gained significant attention in recent years.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Ahmed M. Mansour, Krzysztof Radacki, Ola R. Shehab
Summary: The introduction of a propyl-sulfonic acid group at N1 of the coordinated ligand gives rise to a water-soluble complex that can bind to lysozyme through non-covalent interactions. This complex shows selective moderate toxicity against Cryptococcus neoformans and exhibits no cytotoxicity to healthy HEK293 cells.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Mervette. El Batouti, E. H. El-Mossalamy, H. A. Fetouh
Summary: The work focuses on the preparation and characterization of new optically active charge transfer complexes (CTC) that can harvest weak infra-red photons emitted from sunlight and convert waste heat into useful work. The innovation lies in the development of materials that absorb in the infrared range and have good thermal conductivity. The results have significant impact in material science and academic research.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Shashank Mishra, Erwann Jeanneau, Liang Tian, Ioana Nuta, Elisabeth Blanquet, Deobrat Singh, Rajeev Ahuja, Catherine Marichy, Stephane Daniele
Summary: The modification with 2,2,6,6-tetramethyl-3,5-heptanedione (thdH) enhances the stability and yield of the heterometallic derivative, leading to a rearrangement of the precursor under heating conditions.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Vadim Adamovich, Maria Benitez, Pierre-Luc Boudreault, Maria L. Buil, Miguel A. . Esteruelas, Enrique Onate, Jui-Yi Tsai
Summary: Alkynyl ligands stabilize dimers [Ir(mu-X)(3b)(2)](2) with a cis disposition of the heterocycles of the 3b ligands, in contrast to chloride. The resulting complexes have been used to synthesize orange and green iridium(III) phosphorescent emitters, with the green emitter exhibiting high quantum yield and luminous efficacy in different environments.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Shrinwantu Pal
Summary: In hydrogenation mediated by half-sandwich complexes of Rh, Cp*Rh(iii)-H intermediates play a critical role as hydride-delivery agents. In bipyridine-supported complexes, a unique transformation called 'Cp* non-innocence' gives rise to (Cp*H)Rh(i) intermediates, which are believed to have enhanced hydride-delivery capabilities. However, DFT calculations show that (Cp*H)Rh(i) intermediates do not compete with the conventional pathway involving Cp*Rh(iii)-H, but rather result in sequential hydrogenation of the Cp* framework, potentially leading to catalyst degradation. Therefore, caution is advised when considering the truly homogeneous nature of hydrogenation catalysis mediated by this popular class of complexes.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Leon Escomel, Naime Soule, Emmanuel Robin, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Chloe Thieuleux, Clement Camp
Summary: We report a novel alkane elimination approach that involves the protonolysis of triisobutylaluminum by the acidic hydrides from Cp*IrH4. This strategy allows the synthesis of well-defined iridium aluminum polyhydride clusters with original structures and reactivities.
INORGANIC CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Jia Wang, Zezhi Shan, Xiao Tan, Xinxiang Li, Zhenqi Jiang, Jieling Qin
Summary: The study successfully prepared graphene oxide/Lanthanum coordination polymer (GLCP) nanocomposites and demonstrated their broad-spectrum antibacterial activities against seven typical Pathogenic bacteria. The morphologies and structures of the GLCP were characterized using various techniques, and the bactericidal effects were investigated through different methods. The findings suggest the potential for further applications of GLCP as bactericidal materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Physical
Adrien P. Yepseu, Thomas Girardet, Linda D. Nyamen, Solenne Fleutot, Kevin I. Y. Ketchemen, Franck Cleymand, Peter T. Ndifon
Summary: Two copper(II) complexes were synthesized and used as single-source precursors for the synthesis of amine-capped Cu9S5 copper sulfide nanoparticles. The nanoparticles were characterized and used as catalysts for the photocatalytic degradation of methylene blue. The study revealed the crystalline nature and morphology of the synthesized nanoparticles.
Article
Chemistry, Inorganic & Nuclear
Vadim Adamovich, Llorenc Benavent, Pierre-Luc T. Boudreault, Miguel A. . Esteruelas, Ana M. Lopez, Enrique Onate, Jui-Yi Tsai
Summary: The organic molecule H3L was used to synthesize the Ir(III) derivative Ir(kappa 6-fac-C,C ',C ''-fac-N,N ',N ''-L). This compound was formed through coordination and CH bond activation. Reactions were carried out using different starting materials, and different solvents affected the coordination of H3L. The resulting Ir(kappa 6-fac-C,C ',C ''-fac-N,N ',N ''-L) complex showed phosphorescent emission and was utilized in the fabrication of yellow emitting devices with specific properties.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Zora Popovic, Neven Smrecki, Ozren Jovic, Katarina Miskovic Spoljaric, Dajana Gaso-Sokac, Valentina Busic, Suncica Roca, Berislav Markovic
Summary: The synthesis and characterization of four palladium(II) complexes with N-benzyliminodiacetic acid ligands were studied. These complexes exhibited valuable antiproliferative activity against various cell lines, with the inhibitory effect on cell growth in the order of 4 > 1 > 2 > 3.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Aleksandra M. Dabrowska, Paulina Mech-Warda, Michal Wera, Marta Domzalska, Mariusz Makowski, Agnieszka Chylewska
Summary: A new Schiff base molecule, ScB-SAM, was synthesized and its solid state keto-enol tautomerism was found to exist as a complex equilibrium system. Experimental results were supported by computational calculations. The stability of complexes formed between ScB-SAM and trivalent metal ions in water solution was also confirmed through spectrophotometric titration methods.
Article
Chemistry, Multidisciplinary
Edison Matamala-Cea, Luciano Becerra-Pino, Walter A. Rabanal-Leon, Rodrigo Arancibia, Paulina Hidalgo, Claudio A. Jimenez, Nestor Novoa
Summary: The dissymmetrical and dipolar Y(III) complex and its cationic precursor were synthesized using conventional and microwave-assisted techniques, and characterized through various analysis methods. This study provides an efficient pathway for preparing monoporphyrinate complexes without the need for Diglyme.
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
E. V. Novikova, K. L. Isakovskaya, A. V. Ivanov
Summary: Heteroleptic compounds of bismuth(III) adopting a new binuclear structural type have been isolated and studied. The structures of these compounds were characterized by X-ray diffraction, IR spectroscopy, and simultaneous thermal analysis.
RUSSIAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
A. K. Fazlur Rahman, Martin A. Bennett
Summary: The activation of C-C bond in coordinated M (eta(4) bicyclo [2.2.1]-hepta-diene) or 2,5-NBD via protonation for 3d,4d and 5d transition metals has been investigated, leading to the formation of transient agostic metal hydrides and stable vinyl eta(3) cyclopentenyl cations under specific conditions. Protonation reactions with different acids resulted in variable stability of the hydride complexes and subsequent ligand migration for stable products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ronnie C. Mease, Choong Mo Kang, Vivek Kumar, Sangeeta Ray Banerjee, Il Minn, Mary Brummet, Kathleen L. Gabrielson, Yutian Feng, Andrew Park, Ana P. Kiess, George Sgouros, Ganesan Vaidyanathan, Michael R. Zalutsky, Martin G. Pomper
Summary: This study synthesized a new radiotracer, At-211-3-Lu, for the treatment of PSMA-positive prostate cancer. The results showed that At-211-3-Lu had low toxicity, significant therapeutic effects, and no significant off-target toxicity.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Chemistry, Physical
Monika Kalinowska, Ewelina Golebiewska, Liliana Mazur, Hanna Lewandowska, Marek Pruszynski, Grzegorz Swiderski, Marta Wyrwas, Natalia Pawluczuk, Wlodzimierz Lewandowski
Summary: The Mg(II) and Mn(II)/Na(I) complexes of isoferulic acid were synthesized and characterized, with the Mg(II) complex showing higher antioxidant activity compared to the ligand alone. On the other hand, the Mn(II)/Na(I) complex exhibited slightly lower activity than the isoferulic acid itself.
Article
Nanoscience & Nanotechnology
Yang Liu, Zhengyuan Zhou, Yutian Feng, Xiao-Guang Zhao, Ganesan Vaidyanathan, Michael R. Zalutsky, Tuan Vo-Dinh
Summary: Developing an innovative At-211 nanoplatform with high radiolabeling efficiency and low in vivo deastatination for targeted alpha-particle therapy (TAT) to treat cancer showed promising results. The new platform demonstrated high labeling efficiency, excellent in vivo stability, and significant tumor growth inhibition.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Oncology
Janik Puttemans, Benoit Stijlemans, Marleen Keyaerts, Sam Vander Meeren, Wim Renmans, Karel Fostier, Pieterjan Debie, Heleen Hanssens, Magdalena Rodak, Marek Pruszynski, Kim De Veirman, Karin Vanderkerken, Tony Lahoutte, Alfred Morgenstern, Frank Bruchertseifer, Nick Devoogdt, Matthias D'Huyvetter
Summary: Multiple myeloma is an incurable cancer, and the lack of effective treatment options has led to disease recurrence. However, patient-specific membrane-expressed paraproteins could hold the key to targeting residual cells responsible for disease recurrence. In this study, radiolabeled anti-idiotypic camelid single-domain antibody fragments (sdAbs) were used as tumor-restrictive vehicles and showed potential for personalized medicine in multiple myeloma patients.
MOLECULAR CANCER THERAPEUTICS
(2022)
Review
Chemistry, Physical
Nasrin Abbasi Gharibkandi, Joanna Gieraltowska, Kamil Wawrowicz, Aleksander Bilewicz
Summary: This review discusses the concept of nanoparticle-mediated radionuclide delivery in cancer treatment and its applications. It presents the development of nanostructures for cancer therapy using Auger electron radionuclides, different types of nanoconstructs as carriers, design principles, nanoparticle materials, and target vectors that overcome challenges. Additionally, systems using high-Z element nanoparticles as radionuclide carriers are discussed.
Article
Multidisciplinary Sciences
Yutian Feng, Rebecca Meshaw, Darryl McDougald, Zhengyuan Zhou, Xiao-Guang Zhao, Stephen A. Jannetti, Robert E. Reiman, Erica Pippen, Robin Marjoram, Jeffrey L. Schaal, Ganesan Vaidyanathan, Michael R. Zalutsky
Summary: Radiopharmaceutical therapy has shown promise in the treatment of disseminated cancers, and this study highlights the potential of using HER2-targeted VHH_1028 as a radiopharmaceutical. The results demonstrate that VHH_1028 has higher tumor uptake and lower kidney accumulation compared to the current clinical radiopharmaceutical. Additionally, the use of a solid-phase extraction method for purification of the radiopharmaceutical shows favorable therapeutic effects on tumor growth.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Zhengyuan Zhou, Michael R. Zalutsky, Satish K. Chitneni
Summary: Stapled peptide VIP116 has shown potential as a radiolabeled agent targeting MDM2, with high cell uptake and specificity. Tissue distribution studies reveal stable tumor uptake and high tumor-to-muscle ratios, while metabolic stability studies indicate intact activity in plasma. These findings confirm the suitability of VIP116 scaffold for radiolabeled probe development.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Michal Zuk, Rafal Podgorski, Anna Ruszczynska, Tomasz Ciach, Agnieszka Majkowska-Pilip, Aleksander Bilewicz, Pawel Krysinski
Summary: This study synthesized nanoparticles for multimodal HER2-positive cancer treatment by coating a magnetic core with gold-198 and further modification, achieving targeted therapy effectively. The nanoparticles exhibited good heat mediator properties, specific binding and internalization capabilities towards HER2-positive cancer cells, and degradation ability on tumor spheroids.
Article
Chemistry, Physical
Monika Kalinowska, Kamila Gryko, Ewelina Golebiewska, Grzegorz Swiderski, Hanna Lewandowska, Marek Pruszynski, Malgorzata Zawadzka, Maciej Kozlowski, Justyna Sienkiewicz-Gromiuk, Wlodzimierz Lewandowski
Summary: This study synthesized complexes of chlorogenic acid (5-CQA) with copper(II) and iron(III) and analyzed their properties using various methods. The results showed the possible coordination of the complexes through the carboxylate group and the hydroxyl group from the catechol moiety. The complexes exhibited lower antioxidant properties in aqueous solution compared to 5-CQA alone, but showed higher antioxidant activity in the lipid peroxidation inhibition assay. Cu(II) 5-CQA exhibited the highest pro-oxidant activity among the studied compounds. The complexes were not toxic to HaCaT cells within the tested concentration range.
Article
Engineering, Biomedical
Jeffrey L. Schaal, Jayanta Bhattacharyya, Jeremy Brownstein, Kyle C. Strickland, Garrett Kelly, Soumen Saha, Joshua Milligan, Samagya Banskota, Xinghai Li, Wenge Liu, David G. Kirsch, Michael R. Zalutsky, Ashutosh Chilkoti
Summary: Locally advanced pancreatic tumours that are resistant to conventional radiochemotherapy can be overcome by combining an injectable depot of thermally responsive elastin-like polypeptide with iodine-131 radionuclides and systemically delivered nanoparticle albumin-bound paclitaxel. This combination therapy induces complete tumour regressions in various mouse models of pancreatic tumours. I-131-ELP brachytherapy leads to changes in the expression of intercellular collagen and junctional proteins within the tumour microenvironment, resulting in improved delivery and accumulation of paclitaxel nanoparticles within the tumour.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Medicinal
Yutian Feng, Samantha M. Sarrett, Rebecca L. Meshaw, Ganesan Vaidyanathan, Mike A. Cornejo, Brian M. Zeglis, Michael R. Zalutsky
Summary: The study evaluated a new radiotherapeutic vehicle that can accumulate in tumors with high binding affinity and potential therapeutic efficacy for HER2-positive tumor cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kinga Zelechowska-Matysiak, Kamil Wawrowicz, Mateusz Wierzbicki, Tadeusz Budlewski, Aleksander Bilewicz, Agnieszka Majkowska-Pilip
Summary: In this study, a novel bioconjugate (DOX-AuNPs-Tmab) consisting of gold nanoparticles (AuNPs) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), was synthesized. The bioconjugate exhibited specific binding to HER2 receptors and demonstrated high specificity of binding and internalization capabilities to HER2-positive cancer cells. Cytotoxicity experiments showed that DOX-AuNPs-Tmab significantly reduced cancer cell metabolic activity and surface area of spheroids, inducing cell cycle arrest and late apoptosis. These findings suggest that DOX-AuNPs-Tmab has great potential for targeted therapy of HER2-positive tumors.
Review
Pharmacology & Pharmacy
Honoka Obata, Mikako Ogawa, Michael R. Zalutsky
Summary: The present review explores potential targets/partners for future targeted radionuclide therapy (TRT) strategies. It discusses key factors in the cancer genome, such as DNA damage response/repair and maintenance systems, that contribute to the survival of cancer cells despite receiving high radiation doses. The review suggests targeting DNA maintenance factors as a promising strategy to enhance the effectiveness of TRT, considering their cancer-specific abilities and dysregulated systems.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yutian Feng, Rebecca Meshaw, Xiao-Guang Zhao, Stephen Jannetti, Ganesan Vaidyanathan, Michael R. Zalutsky
Summary: This study evaluates the therapeutic potential of single-domain antibody fragments (sdAbs) combined with alpha-particle therapy for HER2-expressing cancers. The results demonstrate that HER2-specific sdAbs, such as 5F7 and VHH_1028, show better efficacy in tumor growth inhibition compared to HER2-irrelevant VHH_2001, suggesting that combining high-affinity HER2-targeted sdAbs with a residualizing prosthetic agent is a promising strategy for targeted alpha-particle therapy.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Oncology
Daniele Procissi, Stephen A. Jannetti, Markella Zannikou, Zhengyuan Zhou, Darryl McDougald, Deepak Kanojia, Hui Zhang, Kirsten Burdett, Ganesan Vaidyanathan, Michael R. Zalutsky, Irina Balyasnikova
Summary: Low-level brain irradiation induces dynamic changes in tumor vasculature, which increase the delivery of anti-HER2 VHH to intracranial tumors. This finding could facilitate the detection, monitoring, and treatment of HER2-expressing brain metastases.
NEURO-ONCOLOGY ADVANCES
(2022)